1．在宅透析は在宅患者の高齢化、透析医療費の増大を解決する重要な手段の一つである。
2．高尿酸血症患者の増加は著しい。とりわけ腎障害合併高尿酸血症の治療は腎保護の観点からも重要である。

4年　痛風と核酸代謝　講義担当

1. Ichida K, Matsuo H1), Takada T2), Nakayama A1), Murakami K2), Shimizu T(Midorigaoka Hosp.),Yamanashi Y2), Kasuga H2), Nakashima H1), Nakamura T1), Takada Y1), Kawamura Y1), Inoue H1), Okada C1), Utsumi Y1), Nakamura M3), Shinohara Y3)(3Tokyo Univ. of Pharmacy and Life Sciences), Hosoyamada M(Teikyo Univ.), Sakurai Y1), Shinomiya N1)(1National Defense Medical College), Hosoya T, Suzuki H2)(2The Univ. of Tokyo). 6Decreased Extra-renal Urate Excretion is a Common Cause of Hyperuricemia. Nat Commun. 2012, 3:764-70.

2. Tanno Y, Yokoyama K, Hosoya T. Laparoscopic approach for the evaluation of peritoneal injury. Kidney Int. 2012, 82(2):244-5.

3. Hosoya T, Kuriyama S, Ohno I, Kawamura T, Ogura M, Ikeda M, Ishikawa M, Hayashi F, Kanai T, Tomonari H, Soejima M, Akaba K, Tokudome G, Endo S, Fukui A, Gomi H, Hamaguchi A, Hanaoka K, Hara Y, Hara Y, Hasegawa T, Hayakawa H, Hikida M, Hirano K, Horiguchi M, Hosoya M, Ichida K, Imai T, Ishii T, Ishikawa H, Kameda C, Kasai T, Kobayashi A, Kobayashi H, Kurashige M, Kusama Y, Maezawa H, Maezawa Y, Maruyama Y, Matsuda H, Matsuo N, Matsuo T, Miura Y, Miyajima M, Miyakawa M, Miyazaki Y, Mizuguchi M, Nakao M, Nokano H, Ohkido I, Ohtsuka Y, Okada K, Okamoto H, Okonogi H, Saikawa H, Saito H, Sekiguchi C, Suetsugu Y, Sugano N, Suzuki T, Suzuki T, Takahashi H, Takahashi Y, Takamizawa S, Takane K, Morita T, Takazoe K, Tanaka H, Tanaka S, Terawaki H, Toyoshima R, Tsuboi N, Udagawa T, Ueda H, Ueda Y, Uetake M, Unemura S, Utsunomiya M, Utsunomiya Y, Yamada T, Yamada Y, Yamaguchi Y, Yamamoto H, Yokoo T, Yokoyama K, Yonezawa H, Yoshida H, Yoshida M, Yoshizawa T. Antihypertensive effect of a fixed-dose combination of losartan /hydrochlorothiazide in patients with uncontrolled hypertension: a multicenter study. Clin Exp Nephrol. 2012, 16(2):269-78.

4. Terawaki H, Nakano H, Ogura M, Kadomura M (Chiba-East Hosp.), Hosoya T, Nakayama M. Unroofing surgery with en bloc resection of the skin and tissues around the peripheral cuff. Perit Dial Int. 2012, 33(5):573-6.

5. Hosoya T, Kuriyama S, Yoshizawa T, Kobayashi A, Ohtsuka Y, Ohno I. Effect of combined antihypertensive therapy with losartan/hydrochlorthiazide on uric acid metabolism. Intern Med. 2012, 51(18):2509-14.

6. Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N. Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci Rep. 2013, 3:2014. doi: 10.1038/srep02014.

7. Maruyama Y, Taniguchi M, Kazama JJ, Yokoyama K, Hosoya T, Yokoo T, Shigematsu T, Iseki K, Tsubakihara Y. A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan. Nephrol Dial Transplant. 2014. 29(8):1532-8.

8. Hosoya T, Kimura K, Itoh S, Inaba M, Uchida S, Tomino Y, Makino H, Matsuo S, Yamamoto T , Ohno I, Shibagaki Y, Iimuro S, Imai N , Kuwabara M, Hayakawa H. The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study. Trials. 2013; 16-Jan. doi: 10.1186/1745-6215-15-26.

9. Hosoya T, Ohno I, Nomura S, Hisatome I, Uchida S, Fujimori S, Yamamoto T, Hara S. Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout. CEN. 2014; 18(6):876-84.

10. Maruyama Y, Yokoyama K, Nakayama M, Higuchi C, Sanaka T, Sanaka T, Tanaka Y, Sakai K, Mizuiri S, Otsuka Y, Kuriyama S, Maeba T, Iwasawa H, Nakao T, Hosoya T; EARTH (Evaluation of the Adequacy of Renal replacement THerapy) study group. Combined therapy with peritoneal dialysis and hemodialysis: a multicenter retrospective observational cohort study in Japan. Blood Purif. 2014;38(2):149-53.

平成25年度　痛風財団研究助成金 「第3期慢性腎臓病を伴う高尿酸血症患者を対象としたフェブキソスタット製剤の腎機能抑制効果に関する多施設共同、プラセボ対照、二重盲検、ランダム化並行群間比較試験」