{"id":5877,"date":"2026-03-18T15:14:41","date_gmt":"2026-03-18T06:14:41","guid":{"rendered":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/?page_id=5877"},"modified":"2026-03-29T20:01:25","modified_gmt":"2026-03-29T11:01:25","slug":"thoracic-surgery-disease-vitamin-d","status":"publish","type":"page","link":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/department-all\/thoracic-surgery-disease-vitamin-d\/","title":{"rendered":"\u547c\u5438\u5668\u5916\u79d1 \u75be\u60a3\u89e3\u8aac \u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u790e\u77e5\u8b58\uff08\u304c\u3093\u3068\u306e\u95a2\u9023\uff09"},"content":{"rendered":"<div class=\"lazyblock-tab-menu-link-14kPXS wp-block-lazyblock-tab-menu-link\">\n<div class=\"tab-menu-01 tab__wrap\">\n  <ul class=\"tab__button flexbox_list\">\n                \n      <li class=\"tab-menu-01__link tab-menu-01__link--link\">\n                  <a href=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/department-all\/detail\/?id=424\">\n            \u57fa\u672c\u60c5\u5831          <\/a>\n              <\/li>\n                \n      <li class=\"tab-menu-01__link tab-menu-01__link--link\">\n                  <a href=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/department-all\/detail\/?id=424#schedule\">\n            \u5916\u6765\u62c5\u5f53\u533b\u8868          <\/a>\n              <\/li>\n                \n      <li class=\"tab-menu-01__link tab-menu-01__link--link\">\n                  <a href=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/floormap\/\">\n            \u8a3a\u7642\u30d5\u30ed\u30a2          <\/a>\n              <\/li>\n      <\/ul>\n<\/div>\n<\/div>\n\n<div class=\"lazyblock-inpage-link-01-1qCI5T wp-block-lazyblock-inpage-link-01\"><div class=\"inpage-link-01\">\n    <div class=\"inpage-link-01__title\">\n        <img decoding=\"async\" src=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-content\/themes\/twentytwentyone_child\/images\/common\/icon_list.svg\" alt=\"\u30da\u30fc\u30b8\u5185\u76ee\u6b21\" class=\"toggle_clr\" data-clr=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-content\/themes\/twentytwentyone_child\/images\/common\/icon_list.svg\" data-clrbk=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-content\/themes\/twentytwentyone_child\/images\/common\/icon_list_bk.png\">\n        \u30da\u30fc\u30b8\u5185\u76ee\u6b21\n    <\/div>\n    <ul class=\"inpage-link-01__list\">\n                    <li><a href=\"#intro\">\u306f\u3058\u3081\u306b<\/a><\/li>\n                    <li><a href=\"#vitamin-d-nutrition\">\u30d3\u30bf\u30df\u30f3D\u6804\u990a\u5f37\u5316<\/a><\/li>\n                    <li><a href=\"#vitamin-d-intake\">\u30d3\u30bf\u30df\u30f3D\u6442\u53d6<\/a><\/li>\n                    <li><a href=\"#vitamin-d-bone\">\u30d3\u30bf\u30df\u30f3D\u306e\u9aa8\u3078\u306e\u52b9\u7528<\/a><\/li>\n                    <li><a href=\"#vitamin-d-other-effects\">\u9aa8\u4ee5\u5916\u90e8\u4f4d\u3067\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u52b9\u7528<\/a><\/li>\n                    <li><a href=\"#calcium-regulation\">\u8840\u6db2\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8abf\u7bc0<\/a><\/li>\n                    <li><a href=\"#pth\">PTH\uff08\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff09<\/a><\/li>\n                    <li><a href=\"#calcitonin\">\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\uff08\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\uff09<\/a><\/li>\n                    <li><a href=\"#hypercalcemia\">\u9ad8\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u306e\u75c7\u72b6<\/a><\/li>\n                    <li><a href=\"#vitamin-d-overdose\">\u30d3\u30bf\u30df\u30f3D\u904e\u5270\u306b\u3088\u308b\u5065\u5eb7\u88ab\u5bb3<\/a><\/li>\n                    <li><a href=\"#hypocalcemia\">\u4f4e\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u306e\u75c7\u72b6<\/a><\/li>\n                    <li><a href=\"#vitamin-d-normal-range\">\u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u6e96\u5024\uff08\u6b63\u5e38\u5024\uff09<\/a><\/li>\n                    <li><a href=\"#vitamin-d-normal-rate\">\u30d3\u30bf\u30df\u30f3D\u6b63\u5e38\u8005\u306e\u6bd4\u7387<\/a><\/li>\n                    <li><a href=\"#vitamin-d-recommended\">\u30d3\u30bf\u30df\u30f3D\u63a8\u5968\u6442\u53d6\u91cf<\/a><\/li>\n                    <li><a href=\"#vitamin-d-basics\">\u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u790e\u77e5\u8b58<\/a><\/li>\n                    <li><a href=\"#vitamin-d3-metabolism\">\u30d3\u30bf\u30df\u30f3D3\u306e\u4f53\u5185\u4ee3\u8b1d<\/a><\/li>\n                    <li><a href=\"#references\">\u53c2\u8003\u6587\u732e<\/a><\/li>\n                    <li><a href=\"#takaki-kanehiro\">\u30d3\u30bf\u30df\u30f3\u306e\u7236\u3001\u9ad8\u6728\u517c\u5bdb<\/a><\/li>\n                    <li><a href=\"#award-akiba\">\u5f8c\u85e4\u559c\u4ee3\u5b50\u30fb\u30dd\u30fc\u30eb\u30d6\u30eb\u30c0\u30ea\u79d1\u5b66\u8cde\u53d7\u8cde\uff08\u79cb\u8449\u76f4\u5fd7\uff09<\/a><\/li>\n                    <li><a href=\"#vitamin-d-lung-cancer\">\u80ba\u304c\u3093\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/a><\/li>\n                    <li><a href=\"#award-paper\">\u53d7\u8cde\u8ad6\u6587\u7d39\u4ecb<\/a><\/li>\n                    <li><a href=\"#vitamin-d-cancer-papers\">\u6700\u8fd1\u306e\u304c\u3093\u3068\u30d3\u30bf\u30df\u30f3D\u8ad6\u6587<\/a><\/li>\n                    <li><a href=\"#vitamin-d-recent-papers\">\u6700\u8fd1\u306e\u30d3\u30bf\u30df\u30f3D\u8ad6\u6587<\/a><\/li>\n            <\/ul>\n<\/div>\n<\/div>\n\n\n<p class=\"anchor\" id=\"intro\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-2if6iB wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u306f\u3058\u3081\u306b<\/h2><\/div>\n\n\n<p class=\"mb40\">\u30d3\u30bf\u30df\u30f3D\u306f\u9aa8\u3092\u4e08\u592b\u306b\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u65e5\u672c\u4eba\u306e8\u5272\u3067\u30d3\u30bf\u30df\u30f3D\u306f\u4e0d\u8db3\u3057\u3066\u304a\u308a\u30014\u5272\u3067\u6b20\u4e4f\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3059\u308b\u3068\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u304c\u5897\u52a0\u3059\u308b\u3002\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306f\u9aa8\u304b\u3089\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u653e\u51fa\u3057\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u7dad\u6301\u3059\u308b\u3002 <br>\u30d3\u30bf\u30df\u30f3D\u3092\u98df\u4e8b\u304b\u3089\u306f\u5341\u5206\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3001\u65e5\u5149\u306b\u5f53\u305f\u308b\u3053\u3068\u306b\u3088\u308a\u76ae\u819a\u3067\u5408\u6210\u3055\u308c\u308b\u304c\u3001\u73fe\u4ee3\u793e\u4f1a\u3067\u65e5\u5149\u3092\u5341\u5206\u5f53\u305f\u308b\u3053\u3068\u306f\u5371\u967a\u3067\u3082\u3042\u308b\u3002\u75c5\u9662\u3067\u51e6\u65b9\u3067\u304d\u308b\u30d3\u30bf\u30df\u30f3D\u306f\u6d3b\u6027\u578b\u3067\u3042\u308a\u3001\u533b\u5e2b\u306e\u7ba1\u7406\u4e0b\u306b\u5185\u670d\u3057\u306a\u3044\u3068\u526f\u4f5c\u7528\u306e\u5371\u967a\u304c\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u5929\u7136\u578b\u306e\u30d3\u30bf\u30df\u30f3D\u306a\u306e\u3067\u88dc\u5145\u3059\u308b\u5371\u967a\u306f\u5c11\u306a\u3044\u3002 <br>\u3053\u3053\u3067\u306f\u79c1\u306e\u8abf\u3079\u305f\u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u790e\u77e5\u8b58\u3092\u8ff0\u3079\u308b\uff08\u79cb\u8449\u76f4\u5fd7\uff09\u3002<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-nutrition\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z2psmwS wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u6804\u990a\u5f37\u5316<\/h2><\/div>\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u7c73\u56fd\u3001\u30ab\u30ca\u30c0\u3001\u30a4\u30f3\u30c9\u3001\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306a\u3069\u306e\u56fd\u3067\u3001\u56fd\u6c11\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u3001\u98df\u54c1\u306b\u30d3\u30bf\u30df\u30f3D\u3092\u5165\u308c\u308b\u653f\u7b56\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>Pilz\u3089\u306b\u3088\u308b\u3068\u3001\u653f\u7b56\u3068\u3057\u3066\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u6804\u990a\u5f37\u5316\u306f\u3001\u4f4f\u6c11\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u72b6\u614b\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u52b9\u679c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u65e2\u306b\u7c73\u56fd\u3001\u30ab\u30ca\u30c0\u3001\u30a4\u30f3\u30c9\u3001\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306a\u3069\u306e\u56fd\u3067\u5c0e\u5165\u3055\u308c\u3066\u3044\u308b\u3002\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306a\u3069\u306e\u56fd\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u6cbb\u7642\u306e\u5b89\u5168\u6027\u3001\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u306825\uff08OH\uff09D\u30ec\u30d9\u30eb\u306e\u7528\u91cf\u53cd\u5fdc\u95a2\u4fc2\u3001\u304a\u3088\u3073\u30d3\u30bf\u30df\u30f3D\u5f37\u5316\u306e\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306b\u95a2\u3059\u308b\u77e5\u8b58\u306e\u6700\u8fd1\u306e\u84c4\u7a4d\u306f\u3001\u540c\u69d8\u306e\u8cbb\u7528\u5bfe\u52b9\u679c\u306e\u9ad8\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3001\u516c\u8846\u885b\u751f\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u30d3\u30bf\u30df\u30f3D\u306e\u6804\u990a\u5f37\u5316\u3092\u5c0e\u5165\u304a\u3088\u3073\u5909\u66f4\u3059\u308b\u3001\u5f37\u56fa\u306a\u6839\u62e0\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\u3002 <br>Pilz et al. Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper. Front. Endocrinol., 17 July 2018 | https:\/\/doi.org\/10.3389\/fendo.2018.00373.<\/p>\n\n\n\n<p>Pilz\u3089\uff082018\u5e74\uff09\u306f\u300c\u30d3\u30bf\u30df\u30f3D\u306e\u6804\u990a\u5f37\u5316\u306b\u95a2\u3059\u308b\u5408\u7406\u6027\u3068\u8a08\u753b\uff1a\u30ec\u30d3\u30e5\u30fc\u3068\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u8ad6\u6587\u300d\u3092\u5831\u544a\u3057\u305f\u3002 <br>\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306f\u304f\u308b\u75c5\u3068\u9aa8\u8edf\u5316\u75c7\u306e\u3088\u3046\u306a\u7b4b\u9aa8\u683c\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u9aa8\u5916\u6027\u75be\u60a3\uff08\u4f8b\u3048\u3070\u6c17\u9053\u611f\u67d3\u75c7\u3001\u5598\u606f\u60aa\u5316\u3001\u598a\u5a20\u5408\u4f75\u75c7\u3068\u65e9\u6b7b\u306b\uff09\u3092\u9632\u6b62\u3082\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u5b9f\u969b\u306b\u306f\u72ec\u7279\u306e\u4ee3\u8b1d\u3067\u3001\u4e3b\u306b\u65e5\u5149\uff08\u3059\u306a\u308f\u3061\u3001\u7d2b\u5916\u7ddaB\u653e\u5c04\u7dda\uff09\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u76ae\u819a\u3067\u5408\u6210\u304b\u3089\u5f97\u3066\u304a\u308a\u3001\u6804\u990a\u306b\u3088\u308b\u6442\u53d6\u304c\u6bd4\u8f03\u7684\u5c0f\u3055\u306a\u5f79\u5272\u3092\u4f1d\u7d71\u7684\u306b\u6f14\u305a\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u98df\u4e8b\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3001\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\uff0825\uff3bOH\uff3dD\uff09\u6fc3\u5ea6\u304c\u30d3\u30bf\u30df\u30f3D\u306e\u72b6\u6cc1\u3092\u8a55\u4fa1\u3059\u308b\u306e\u306b\u7528\u3044\u3089\u308c\u308b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306b\u57fa\u3065\u304f\u3002\u76ee\u6a19\u6fc3\u5ea6\u3067\u226525\u304b\u3089\u226550nmol\/L\uff08\u226510-\u226520ng\/mL\uff09\u306b\u308f\u305f\u3063\u3066\u3044\u3066\u30011\u65e5\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf10\uff5e20\u03bcg\uff08400-800\u56fd\u969b\u5358\u4f4d\uff09\u3068\u4e00\u81f4\u3057\u3066\u63a8\u85a6\u3055\u308c\u305f\u3002\u5927\u90e8\u5206\u306e\u4f4f\u6c11\u306f\u3001\u3053\u308c\u3089\u306e\u63a8\u85a6\u3055\u308c\u305f\u98df\u4e8b\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u5fc5\u8981\u91cf\u3092\u6e80\u305f\u3059\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3002\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306f\u3001\u305d\u308c\u305e\u308c\u300125\uff08OH\uff09D\u6fc3\u5ea6\uff1c30nmol\/L\uff0812ng\/mL\uff09\u3068\uff1c50nmol\/L\uff0820ng\/mL\uff09\u306f\u4e00\u822c\u4f4f\u6c11\u306e13.0\u306840.4%\u306b\u5b58\u5728\u3059\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u516c\u5f0f\u306b\u63a8\u85a6\u3055\u308c\u305f\u98df\u4e8b\u306e\u53c2\u7167\u6442\u53d6\u91cf\u3068\u4e00\u822c\u4f4f\u6c11\u306e\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306e\u9ad8\u3044\u78ba\u7387\u9593\u306e\u3053\u306e\u76f8\u5f53\u306a\u30ae\u30e3\u30c3\u30d7\u306f\u3001\u4fdd\u5065\u5f53\u5c40\u304b\u3089\u306e\u884c\u52d5\u3092\u5fc5\u8981\u3068\u3059\u308b\u3002\u66f4\u306a\u308b\u5c4b\u5916\u6d3b\u52d5\u306b\u3088\u308b\u3088\u308a\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u666e\u53ca\u3068\u6700\u9069\u6804\u990a\u306f\u3001\u660e\u3089\u304b\u306b\u6b63\u5f53\u5316\u3055\u308c\u308b\u304c\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306f\u306a\u304f\u306a\u3089\u306a\u3044\u3057\u3001\u65e5\u5149\u9732\u51fa\u306e\u5834\u5408\u3001\u76ae\u819a\u304c\u3093\u306e\u3088\u3046\u306a\u6f5c\u5728\u7684\u526f\u4f5c\u7528\u306b\u95a2\u3057\u3066\u30d0\u30e9\u30f3\u30b9\u304c\u3068\u308c\u3066\u3044\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u88dc\u52a9\u5264\u306e\u6442\u53d6\u306f\u3001\u6bd4\u8f03\u7684\u304d\u3061\u3093\u3068\u6442\u53d6\u3057\u306a\u3044\u3068\u5236\u9650\u3055\u308c\u308b\uff08\u7279\u306b\u4f4e\u793e\u4f1a\u7d4c\u6e08\u5730\u4f4d\u306e\u500b\u4eba\uff09\u3001\u904e\u91cf\u670d\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u7cfb\u7d71\u7684\u30d3\u30bf\u30df\u30f3D\u98df\u7269\u5f37\u5316\u306f\u4e00\u822c\u4f4f\u6c11\u3067\u30d3\u30bf\u30df\u30f3D\u72b6\u6cc1\u3092\u6539\u5584\u3059\u308b\u52b9\u679c\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308b\u3001\u305d\u3057\u3066\u3001\u3053\u308c\u306f\u56fd\u3001\u4f8b\u3048\u3070\u7c73\u56fd\u3001\u30ab\u30ca\u30c0\u3001\u30a4\u30f3\u30c9\u3068\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u3067\u3059\u3067\u306b\u5c0e\u5165\u3055\u308c\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u6cbb\u7642\u306e\u5b89\u5168\u6027\u306e\u6211\u3005\u306e\u77e5\u8b58\u306e\u6700\u8fd1\u306e\u9032\u6b69\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u306825\uff08OH\uff09D\u30ec\u30d9\u30eb\u306e\u7528\u91cf\u53cd\u5fdc\u95a2\u4fc2\u306a\u3089\u3073\u306b\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306e\u3088\u3046\u306a\u56fd\u3067\u306e\u30d3\u30bf\u30df\u30f3D\u5f37\u5316\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u3001\u3053\u306e\u69d8\u306b\u8cbb\u7528\u52b9\u679c\u304c\u3088\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u516c\u8846\u885b\u751f\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u30d3\u30bf\u30df\u30f3D\u98df\u7269\u5f37\u5316\u3092\u5c0e\u5165\u3057\u3001\u4fee\u6b63\u3059\u308b\u305f\u3081\u306e\u3057\u3063\u304b\u308a\u3057\u305f\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u3002 <br>Pilz S. et al. Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper. Front. Endocrinol., 17 July 2018 |<br>https:\/\/doi.org\/10.3389\/fendo.2018.00373<\/p>\n\n\n\n<p class=\"mb40\">\u30d3\u30bf\u30df\u30f3D\u8840\u4e2d\u6fc3\u5ea6\u304c25(OH)D\uff1d20ng\/ml\u3088\u308a\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u6b7b\u4ea1\u5371\u967a\u6027\u304c\u6025\u901f\u306b\u5897\u52a0\u3059\u308b\u3002 <br>Gaksch M et al. PLoS One. 2017 16;12(2):e0170791.<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-intake\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-vtsUL wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u6442\u53d6<\/h2><\/div>\n\n\n<p class=\"mb40\">\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08NCI\uff09\u306b\u3088\u308b\u3068\u3001\u81ea\u7136\u754c\u3067\u306f\u3054\u304f\u308f\u305a\u304b\u306a\u98df\u54c1\u306b\u30d3\u30bf\u30df\u30f3D\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u8102\u80aa\u306e\u591a\u3044\u9b5a\uff08\u30b5\u30b1\u3001\u30de\u30b0\u30ed\u3001\u30b5\u30d0\u306a\u3069\uff09\u3068\u9b5a\u306e\u809d\u6cb9\u306e\u8089\u306f\u6700\u9ad8\u306e\u4f9b\u7d66\u6e90\u3067\u3042\u308b\u3002\u5c11\u91cf\u306e\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u725b\u306e\u809d\u81d3\u3001\u30c1\u30fc\u30ba\u3001\u5375\u9ec4\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u98df\u54c1\u306b\u542b\u307e\u308c\u308b\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u4e3b\u306b\u30d3\u30bf\u30df\u30f3D3\u3068\u305d\u306e\u4ee3\u8b1d\u726925\uff08OH\uff09D3\u306e\u5f62\u3067\u3042\u308b\u3002\u3044\u304f\u3064\u304b\u306e\u30ad\u30ce\u30b3\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u91cf\u306e\u30d3\u30bf\u30df\u30f3D2\u3092\u63d0\u4f9b\u3059\u308b\u3002\u5236\u5fa1\u3055\u308c\u305f\u6761\u4ef6\u4e0b\u3067\u7d2b\u5916\u7dda\u306b\u3055\u3089\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u30d3\u30bf\u30df\u30f3D2\u306e\u30ec\u30d9\u30eb\u304c\u9ad8\u3081\u3089\u308c\u305f\u30ad\u30ce\u30b3\u3082\u5229\u7528\u3067\u304d\u308b\u3002 <br>\u5f37\u5316\u98df\u54c1\u306f\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u98df\u4e8b\u3067\u30d3\u30bf\u30df\u30f3D\u306e\u307b\u3068\u3093\u3069\u3092\u63d0\u4f9b\u3059\u308b\u3002\u305f\u3068\u3048\u3070\u3001\u7c73\u56fd\u306e\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u725b\u4e73\u306f\u3001100 IU \/\u30ab\u30c3\u30d7\uff082.5\u03bcg\/\u30ab\u30c3\u30d7\uff09\u3067\u81ea\u767a\u7684\u306b\u5f37\u5316\u3055\u308c\u3066\u3044\u308b\u3002\u30ab\u30ca\u30c0\u3067\u306f\u3001\u725b\u4e73\u306f\u6cd5\u5f8b\u306b\u3088\u3063\u3066\u3001530 IU \/ 100 g\u4ee5\u4e0a\uff0813.25\u03bcg\/100g\uff09\u306e\u30de\u30fc\u30ac\u30ea\u30f3\u3068\u540c\u69d8\u306b\u300135\uff5e40 IU \/ 100 mL\uff080.875-1ng\/100ml\uff09\u3067\u5f37\u5316\u3055\u308c\u3066\u3044\u308b\u30021930\u5e74\u4ee3\u306b\u306f\u3001\u304f\u308b\u75c5\u3068\u6226\u3046\u305f\u3081\u306b\u7c73\u56fd\u3067\u30df\u30eb\u30af\u5f37\u5316\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u5b9f\u65bd\u3055\u308c\u3001\u305d\u306e\u5f8c\u4e3b\u8981\u306a\u516c\u8846\u885b\u751f\u554f\u984c\u3068\u306a\u3063\u305f\u3002\u30c1\u30fc\u30ba\u3084\u30a2\u30a4\u30b9\u30af\u30ea\u30fc\u30e0\u306a\u3069\u3001\u725b\u4e73\u304b\u3089\u4f5c\u3089\u308c\u305f\u4ed6\u306e\u4e73\u88fd\u54c1\u306f\u3001\u901a\u5e38\u5f37\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u3059\u3050\u306b\u98df\u3079\u3089\u308c\u308b\u671d\u98df\u7528\u30b7\u30ea\u30a2\u30eb\u306b\u306f\u3001\u591a\u304f\u306e\u30d6\u30e9\u30f3\u30c9\u306e\u30aa\u30ec\u30f3\u30b8\u30b8\u30e5\u30fc\u30b9\u3001\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u30de\u30fc\u30ac\u30ea\u30f3\u3001\u305d\u306e\u4ed6\u306e\u98df\u54c1\u3068\u540c\u69d8\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308b\u3002\u690d\u7269\u4e73\u306e\u4ee3\u66ff\u54c1\uff08\u5927\u8c46\u3001\u30a2\u30fc\u30e2\u30f3\u30c9\u3001\u307e\u305f\u306f\u30aa\u30fc\u30c8\u9ea6\u304b\u3089\u4f5c\u3089\u308c\u305f\u98f2\u6599\u306a\u3069\uff09\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u30d3\u30bf\u30df\u30f3D\u3067\u5f37\u5316\u725b\u4e73\u306b\u542b\u307e\u308c\u308b\u91cf\uff08\u7d04100 IU\uff082.5\u03bcg\uff09\/\u30ab\u30c3\u30d7\uff09\u307e\u3067\u5f37\u5316\u3055\u308c\u3066\u3044\u308b\u3002 \u6804\u990a\u8868\u793a\u30e9\u30d9\u30eb\u306b\u5b9f\u969b\u306e\u91cf\u304c\u30ea\u30b9\u30c8\u3055\u308c\u3066\u3044\u308b\u3002 <br>\u7c73\u56fd\u3068\u30ab\u30ca\u30c0\u306e\u4e21\u65b9\u3067\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u542b\u3080\u7c89\u30df\u30eb\u30af\u306e\u5f37\u5316\u304c\u7fa9\u52d9\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\u3002\u7c73\u56fd\u3067\u306f40\uff5e100 IU \uff081\uff5e2.5\u03bcg\uff09\/ 100 kcal\u3001\u30ab\u30ca\u30c0\u3067\u306f40\uff5e80 IU \uff081\uff5e2\u03bcg\uff09\/ 100 kcal\u3067\u3042\u308b\u3002 <br>NCI\/Office of dietary suppliments\/ Fact Sheet for Health Professionals\/Vitamin D\u3000https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\u3000 Nov. 9. 2019\u3002 <br>5\/35\u3000Sources of vitamin D<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-bone\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-1jpjGj wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u306e\u9aa8\u3078\u306e\u52b9\u7528<\/h2><\/div>\n\n\n<p>\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08NCI\uff09\u306b\u3088\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u3002\u5e7e\u3064\u304b\u306e\u98df\u54c1\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u3082\u6442\u53d6\u3067\u304d\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u65e5\u5149\u306b\u5f53\u305f\u308b\u3053\u3068\u306b\u3088\u308a\u76ae\u819a\u3067\u4f5c\u3089\u308c\u308b\u3002\u65e5\u5149\u3084\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u6442\u53d6\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u306f\u751f\u7269\u5b66\u7684\u306b\u4e0d\u6d3b\u6027\u578b\u3067\u3042\u308a\u3001\u4f53\u5185\u3067\uff12\u56de\u306e\u4f5c\u308a\u66ff\u3048\uff08\u6c34\u9178\u5316\uff09\u3092\u7d4c\u3066\u6d3b\u6027\u578b\u3068\u306a\u308b\u3002 <br>\u5341\u5206\u306a\u30d3\u30bf\u30df\u30f3D\u304c\u306a\u3044\u3068\u9aa8\u306f\u7d30\u304f\u3001\u8106\u304f\u3001\u3044\u3073\u3064\u306b\u306a\u308b\u3002\u5341\u5206\u306a\u30d3\u30bf\u30df\u30f3D\u306f\u5c0f\u5150\u3067\u304f\u308b\u75c5\u3092\u4e88\u9632\u3057\u3001\u6210\u4eba\u3067\u9aa8\u8edf\u5316\u75c7\u3092\u4e88\u9632\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30d3\u30bf\u30df\u30f3D\u306f\u9ad8\u9f62\u8005\u306e\u9aa8\u7c97\u9b06\u75c7\u3092\u4e88\u9632\u3059\u308b\u3002 <br>NCI\/Office of dietary suppliments\/ Fact Sheet for Health Professionals\/Vitamin D\u3000https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\u3000Nov. 9. 2019. <br>Introduction. 1\/33.\u3000<\/p>\n\n\n\n<p>\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08NCI\uff09\u306b\u3088\u308b\u3068\u3001\u9aa8\u304a\u3088\u3073\u4e00\u822c\u7684\u306a\u5065\u5eb7\u306e\u305f\u3081\u306e25\uff08OH\uff09D\uff08\u30d3\u30bf\u30df\u30f3D\uff09\u306e\u6700\u9069\u306a\u8840\u6e05\u6fc3\u5ea6\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u3053\u308c\u3089\u306f\u3001\u9078\u629e\u3055\u308c\u305f\u751f\u7406\u5b66\u7684\u610f\u7fa9\u306b\u5fdc\u3058\u3066\u3001\u4eba\u751f\u306e\u5404\u6bb5\u968e\u3067\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u8840\u6e0525\uff08OH\uff09D\u306f\u30d3\u30bf\u30df\u30f3D\u3078\u306e\u66b4\u9732\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08\u592a\u967d\u3001\u98df\u7269\u3001\u304a\u3088\u3073\u6804\u990a\u88dc\u52a9\u98df\u54c1\u304b\u3089\uff09\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u304c\u3001\u3069\u306e\u30ec\u30d9\u30eb\u304c\u5065\u5eb7\u3078\u306e\u5f71\u97ff\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u7bc4\u56f2\u304b\u306f\u660e\u78ba\u306b\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u3002 <br>NCI\/Office of dietary suppliments\/ Fact Sheet for Health Professionals\/Vitamin D\u3000https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\u3000 Nov. 9. 2019. <br>Vitamin D and Health.14\/33.<\/p>\n\n\n\n<p>\u6d25\u5ddd\u5c1a\u5b50\u306b\u3088\u308b\u3068\u3001\u8840\u4e2d25\uff08OH\uff09D\uff08\u30d3\u30bf\u30df\u30f3D\uff09\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3001\u307e\u305f\u306f\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff1a\u30d1\u30e9\u30bd\u30eb\u30e2\u30f3\uff09\u304c\u5206\u6ccc\u3055\u308c\u3001\u5c0f\u8178\u304b\u3089\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u4fc3\u9032\u3001\u814e\u81d3\u304b\u3089\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u518d\u5438\u53ce\u3001\u9aa8\u304b\u3089\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u52d5\u54e1\uff08\u653e\u51fa\uff09\u3092\u884c\u3044\u3001\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u3002\u307e\u305f\u3001\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u306f\u814e\u81d3\u306b\u4f5c\u7528\u3057\u300125\uff08OH\uff09D\u304b\u30891,25\uff08OH\uff092D\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u3002<br>1.25\uff08OH\uff09\uff12D\u3084\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u306e\u4e0a\u6607\u306f\u3001\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u306e\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u3002 <br>\u6d25\u5ddd\u5c1a\u5b50\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u69cb\u9020\u30fb\u4ee3\u8b1d\u30fb\u4f5c\u7528\u3002\u5e73\u7530\u7d50\u559c\u7dd2\u76e3\u4fee\u3002\u7af9\u5185\u9756\u535a\u3001\u6749\u672c\u5229\u55e3\u3001\u6210\u702c\u5149\u6804\u7de8\u96c6\u3002\u7532\u72b6\u817a\u30fb\u9aa8\u4ee3\u8b1d\u75be\u60a3\u8a3a\u7642\u30de\u30cb\u30e5\u30a2\u30eb\u3002\uff507-11\u3002\u6539\u8a02\u7b2c2\u7248\u3002\u8a3a\u65ad\u3068\u6cbb\u7642\u793e\u3002\u6771\u4eac\u30022015.1.5\u3002<\/p>\n\n\n<div class=\"lazyblock-list-05-zeTzX mb40 wp-block-lazyblock-list-05\"><div class=\"list-05\">\n    <ul>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308a\u3001\u305f\u3093\u3071\u304f\u8cea\u3068\u7d50\u5408\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u3001\u30d3\u30bf\u30df\u30f3D( 25(OH)D )\u3001\u30d3\u30bf\u30df\u30f3D( 1,25(OH)2D\uff09\u3068\u3057\u3066\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u3002<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u306f\u8840\u6db2\u4e2d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30ea\u30f3\u306e\u6fc3\u5ea6\u3092\u8abf\u6574\u3059\u308b\u3002<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u306f\u91cd\u8981\u306a\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u3002<\/p><\/li>\n            <li><p>\u9aa8\u306f\u5e38\u306b\u30ea\u30d5\u30a9\u30fc\u30e0\u3092\u7e70\u308a\u8fd4\u3057\u3066\u3044\u308b\u3002\u3064\u307e\u308a\u3001\u9aa8\u306f\u5e38\u306b\u9aa8\u5438\u53ce\uff08\u7834\u9aa8\uff09\u3068\u9aa8\u5f62\u6210\uff08\u9020\u9aa8\uff09\u3092\u7e70\u308a\u8fd4\u3057\u3001\u65b0\u3057\u3044\u9aa8\u306b\u4f5c\u308a\u66ff\u3048\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u6750\u6599\u3068\u306a\u308b\u8840\u6db2\u4e2d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u91cf\u306f\u91cd\u8981\u3067\u3042\u308b\u3002<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\uff081,25(OH)2D\uff09\u306f\u8178\u7ba1\u3088\u308a\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30ea\u30f3\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3059\u308b\u3002<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\uff081,25(OH)2D\uff09\u306f\u9aa8\u306b\u4f5c\u7528\u3057\u3066\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30ea\u30f3\u3092\u52b9\u7387\u826f\u304f\u9aa8\u306b\u84c4\u7a4d\u3059\u308b\u3002<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u306f\u98df\u54c1\u3068\u3057\u3066\u6442\u53d6\u3059\u308b\u304b\u3001\u65e5\u5149\u306b\u5f53\u305f\u308a\u76ae\u819a\u3067\u5408\u6210\u3059\u308b\u304b\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u6442\u53d6\u3055\u308c\u308b\u3002<\/p><\/li>\n            <li><p>1,25(OH)2D\u306f\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3068\u547c\u3070\u308c\u300125(OH) D\u304b\u3089\u4f5c\u3089\u308c\u308b\u3002\u307e\u305f\u3001\u85ac\u7269\u3068\u3057\u3066\u51e6\u65b9\u3055\u308c\u308b\u3002<\/p><\/li>\n            <li><p>1,25(OH)2D\u306e\u8840\u4e2d\u6fc3\u5ea6\u306f\u300125(OH) D\u306e\u7d04\u5343\u5206\u306e1\u300120-70pg\/ml\u3067\u3042\u308b\u3002<\/p><\/li>\n            <li><p>25(OH) D\uff08\u30d3\u30bf\u30df\u30f3D\uff09\u306e\u8840\u4e2d\u534a\u6e1b\u671f\u306f\u7d04\uff13\u9031\u9593\u304b\u308930\u65e5\u3001\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\uff081,25(OH)2D\uff09\u306e\u8840\u4e2d\u534a\u6e1b\u671f\u306f\u7d041\u65e5\u3067\u3042\u308b\u3002<\/p><\/li>\n            <li><p>25(OH) D\u306e\u8840\u4e2d\u6fc3\u5ea6\u6e2c\u5b9a\u306f\u9aa8\u7c97\u9b06\u75c7\u306b\u5bfe\u30572018\u5e749\u6708\u306b\u4fdd\u967a\u53ce\u8f09\u3055\u308c\u305f\u3002<\/p><\/li>\n        <\/ul>\n<\/div>\n<\/div>\n\n\n<p class=\"anchor\" id=\"vitamin-d-other-effects\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z2efEQK wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u9aa8\u4ee5\u5916\u90e8\u4f4d\u3067\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u52b9\u7528<\/h2><\/div>\n\n\n<p>Pitz\u3089\u306f\u5831\u544a\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u9aa8\u306e\u6210\u9577\u3084\u518d\u751f\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u5897\u6b96\u3001\u795e\u7d4c\u7b4b\u3001\u514d\u75ab\u6a5f\u80fd\u3001\u708e\u75c7\u3092\u5909\u5316\u3055\u305b\u3066\u3044\u308b\u3002\u6700\u8fd1\u306e\u591a\u304f\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6b20\u4e4f\u306f\u3001\u547c\u5438\u5668\u611f\u67d3\u75c7\u3084\u547c\u5438\u5668\u75be\u60a3\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u5404\u7a2e\u304c\u3093\u3001\u7cd6\u5c3f\u75c5\u3001\u75f4\u307b\u3046\u75c7\u3001\u3046\u3064\u75c5\u3001\u598a\u5a20\u7d50\u679c\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <br>Pilz et al. Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper. Front. <br>Endocrinol., 17 July 2018 | https:\/\/doi.org\/10.3389\/fendo.2018.00373.<\/p>\n\n\n\n<p>\u79cb\u8449\u76f4\u5fd7\u3001\u6d66\u5cf6\u5145\u4f73\u3089\u306f\u5831\u544a\u3057\u305f\u3002\u80ba\u304c\u3093\u306b\u5bfe\u3059\u308b\u4e8c\u91cd\u76f2\u691c\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u4f4e25(OH)D\u30ec\u30d9\u30eb\uff1c20ng\/mL\u3067\u3001\u521d\u671f\u80ba\u817a\u304c\u3093\u60a3\u8005\u306e\u751f\u5b58\u3092\u6539\u5584\u3057\u305f\u3002 <br>\u79cb\u8449\u76f4\u5fd7\u3001\u6d66\u5cf6\u5145\u4f73\u3089\uff0e\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306e\u751f\u5b58\uff1a\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3002 <br>Clin Cancer Res. 2018 Sep 1;24(17):4089-4097.<\/p>\n\n\n\n<p>\u6d25\u5ddd\u5c1a\u5b50\u306b\u3088\u308b\u3068\u3001\u4e3b\u306a\u30d3\u30bf\u30df\u30f3D\u306e\u4f5c\u7528\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u3092\u4ecb\u3057\u305f1,25\uff08OH\uff092D\u306e\u4f5c\u7528\u3067\u3042\u308b\u3002VDR\u306f\u5168\u8eab\u306e\u7d44\u7e54\u306b\u3042\u308a\u3001\u5c0f\u8178\u3001\u814e\u81d3\u3001\u9aa8\u306b\u304a\u3044\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u4ee3\u8b1d\u8abf\u7bc0\u3092\u884c\u3063\u3066\u3044\u308b\u4ed6\u3001\u7d30\u80de\u5897\u6b96\u3001\u5206\u5316\u8abf\u7bc0\u4f5c\u7528\u3001\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u3001\u9aa8\u683c\u7b4b\u6a5f\u80fd\u3001\u8840\u5727\u8abf\u7bc0\u4f5c\u7528\u3001\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u95a2\u4e0e\u306a\u3069\u3092\u884c\u3046\u3002 <br>25\uff08OH\uff09D\u306f\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3067\u306f\u306a\u3044\u304c\u3001PTH\u5206\u6ccc\u6291\u5236\u4f5c\u7528\u3001\u9aa8\u6298\u8ee2\u5012\u4e88\u9632\u3001\u5fc3\u8840\u7ba1\u7cfb\u3001\u514d\u75ab\u7cfb\u75be\u60a3\u3068\u306e\u95a2\u4fc2\u304c\u75ab\u5b66\u7814\u7a76\u3067\u6570\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002 <br>\u6d25\u5ddd\u5c1a\u5b50\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u69cb\u9020\u30fb\u4ee3\u8b1d\u30fb\u4f5c\u7528\u3002\u5e73\u7530\u7d50\u559c\u7dd2\u76e3\u4fee\u3002\u7af9\u5185\u9756\u535a\u3001\u6749\u672c\u5229\u55e3\u3001\u6210\u702c\u5149\u6804\u7de8\u96c6\u3002\u7532\u72b6\u817a\u30fb\u9aa8\u4ee3\u8b1d\u75be\u60a3\u8a3a\u7642\u30de\u30cb\u30e5\u30a2\u30eb\u3002\uff507-11\u3002\u6539\u8a02\u7b2c2\u7248\u3002\u8a3a\u65ad\u3068\u6cbb\u7642\u793e\u3002\u6771\u4eac\u30022015.1.5<\/p>\n\n\n\n<p class=\"mb40\">\u4e95\u4e0a\u5927\u8f14\u306b\u3088\u308b\u3068\u3001\u591a\u304f\u306e\u75be\u60a3\u306825\uff08OH\uff09D\u6fc3\u5ea6\u4f4e\u5024\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u4e2d\u306b\u306f\u3001\u764c\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u7d50\u6838\u3001\u8a8d\u77e5\u75c7\u3001\u3046\u3064\u75c5\u3001\u9ad8\u8840\u5727\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3001\u80a5\u6e80\u30012\u578b\u7cd6\u5c3f\u75c5\u306a\u3069\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u4ecb\u5165\u306b\u3088\u308a\u6539\u5584\u52b9\u679c\u304c\u793a\u3055\u308c\u305f\u3082\u306e\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u3084\u6b20\u4e4f\u306f\u539f\u56e0\u3067\u306f\u306a\u304f\u3001\u75be\u60a3\u306b\u968f\u4f34\u3059\u308b\u7d50\u679c\u306b\u904e\u304e\u306a\u3044\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u4e00\u822c\u5316\u3057\u3064\u3064\u3042\u308b\u3002 <br>\u4e95\u4e0a\u5927\u8f14\u3002\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u30fb\u6b20\u4e4f\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u3002\u5e73\u7530\u7d50\u559c\u7dd2\u76e3\u4fee\u3002\u7af9\u5185\u9756\u535a\u3001\u6749\u672c\u5229\u55e3\u3001\u6210\u702c\u5149\u6804\u7de8\u96c6\u3002\u7532\u72b6\u817a\u30fb\u9aa8\u4ee3\u8b1d\u75be\u60a3\u8a3a\u7642\u30de\u30cb\u30e5\u30a2\u30eb\u3002\uff50202-6\u3002\u6539\u8a02\u7b2c2\u7248\u3002\u8a3a\u65ad\u3068\u6cbb\u7642\u793e\u3002\u6771\u4eac\u30022015.1.5\u3002<\/p>\n\n\n\n<p class=\"anchor\" id=\"calcium-regulation\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-ZVmV8B wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u8840\u6db2\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8abf\u7bc0<\/h2><\/div>\n\n<div class=\"lazyblock-list-01-m4nne mb40 wp-block-lazyblock-list-01\">\n<div class=\"list-01\" style=\"counter-reset: list01 0;\">\n  <ol>\n          <li><p>PTH \uff08\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff09<\/p><\/li>\n          <li><p>\u30d3\u30bf\u30df\u30f3D<\/p><\/li>\n          <li><p>\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\uff08\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\uff09<\/p><\/li>\n      <\/ol>\n<\/div><\/div>\n\n\n<p class=\"anchor\" id=\"pth\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-1CWYlR wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">PTH\uff08\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff09<\/h2><\/div>\n\n<div class=\"lazyblock-list-05-ZATKEY mb40 wp-block-lazyblock-list-05\"><div class=\"list-05\">\n    <ul>\n            <li><p>PTH\uff08\u30d1\u30e9\u30bd\u30eb\u30e2\u30f3\uff09\u306f\u526f\u7532\u72b6\u817a\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u3002<\/p><\/li>\n            <li><p>\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u4f4e\u4e0b\u3059\u308b\u3068PTH\u306e\u5206\u6ccc\u304c\u4fc3\u9032\u3055\u308c\u308b\u3002<\/p><\/li>\n            <li><p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:70,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">PTH\u306e\u4f5c\u7528<br \/><\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:70,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u00a01. \u9aa8\u304b\u3089\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u653e\u51fa\u3059\u308b\u3002<br \/>\u00a02. \u814e\u81d3\u3067\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u6392\u51fa\u3092\u6291\u5236\u3059\u308b\u3002<br \/>\u00a03. \u814e\u81d3\u3067\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u3002<\/span><\/p><\/li>\n            <li><p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:149,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u5ca1\u5d0e\u3000\u4eae\u3002\u65e5\u8001\u533b\u8a8c\u30002009\uff1a46\uff1b125-7.<\/span> <span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:174,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u3000 <br \/>\u00a01. \u8840\u6e05\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u4f4e\u4e0b\u3059\u308b\u3068PTH\u5206\u6ccc\u304c\u4ea2\u9032\u3059\u308b\u3002 \u3000 <br \/>\u00a02. \u6301\u7d9a\u7684\u306bPTH\u304c\u5206\u6ccc\u3055\u308c\u308b\u3068\u3001\u9aa8\u5438\u53ce\u304c\u9aa8\u5f62\u6210\u3088\u308a\u5f37\u304f\u3001\u9aa8\u91cf\u306f\u4f4e\u4e0b\u3059\u308b\u3002 \u3000 <br \/>\u00a03. PTH\u306e\u4e0a\u6607\u306f\u4e00\u822c\u7684\u306b\u9aa8\u5bc6\u5ea6\u6e1b\u5c11\u901f\u5ea6\u306e\u5897\u52a0\u3068\u9aa8\u6298\u5371\u967a\u5ea6\u4e0a\u6607\u3092\u3082\u305f\u3089\u3059\u3002 \u3000 <br \/>\u00a04. \u85ac\u5264\u3068\u3057\u3066\u9593\u6b20\u7684\u306bPTH\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u9aa8\u5f62\u6210\u304c\u9aa8\u5438\u53ce\u3092\u4e0a\u56de\u308a\u3001\u9aa8\u91cf\u306f\u5897\u52a0\u3059\u308b\u3002<\/span><\/p><\/li>\n        <\/ul>\n<\/div>\n<\/div>\n\n\n<p class=\"anchor\" id=\"calcitonin\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-5GySj wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\uff08\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\uff09<\/h2><\/div>\n\n<div class=\"lazyblock-list-05-ZE2RWN mb40 wp-block-lazyblock-list-05\"><div class=\"list-05\">\n    <ul>\n            <li><p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:47,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">Ca\u00b2\u207a<\/span>\u4f4e\u4e0b\u4f5c\u7528<\/p><\/li>\n            <li><p>\u98df\u5f8c\u306e\u8840\u4e2dCa\u5897\u52a0\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u3001\u8840\u4e2dCa\u6fc3\u5ea6\u3092\u4e0b\u3052\u308b<\/p><\/li>\n            <li><p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:47,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u9aa8\u3078Ca\u00b2\u207a\u6c88\u7740\uff1a\u9aa8\u3078\u306e\u30ea\u30f3\u9178Ca\u306e\u6c88\u7740\u3092\u4fc3\u9032\u3055\u305b\u3001\u8840\u4e2dCa\u30a4\u30aa\u30f3\u3092\u4f4e\u4e0b<\/span><\/p><\/li>\n            <li><p>\u5c3f\u3078<span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:47,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">Ca\u00b2\u207a\u6392\u51fa<\/span><\/p><\/li>\n        <\/ul>\n<\/div>\n<\/div>\n\n\n<p class=\"anchor\" id=\"hypercalcemia\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z1kHG3z wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u9ad8\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u306e\u75c7\u72b6<\/h2><\/div>\n\n\n<p class=\"mb40\">\u60aa\u5fc3\u3001\u5614\u5410\u3001\u98df\u6b32\u4f4e\u4e0b\u3001\u53e3\u6e07\u611f\u3001\u591a\u98f2\u3001\u591a\u5c3f\u3001\u8131\u529b\u3001\u610f\u8b58\u969c\u5bb3\u3002<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-overdose\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z1BLdu5 wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u904e\u5270\u306b\u3088\u308b\u5065\u5eb7\u88ab\u5bb3<\/h2><\/div>\n\n\n<p class=\"mb40\">\u30d3\u30bf\u30df\u30f3D\u306e\u904e\u5270\u306b\u3088\u308a\u3001\u9ad8\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u304c\u8d77\u3053\u308a\u3001\u98df\u6b32\u4e0d\u632f\u3001\u4f53\u91cd\u6e1b\u5c11\u3001\u591a\u5c3f\u3001\u4e0d\u6574\u8108\u306a\u3069\u306e\u75c7\u72b6\u304c\u3042\u308b\u3002 <br>\u3088\u308a\u91cd\u75c7\u306a\u3082\u306e\u3067\u306f\u3001\u8840\u7ba1\u3084\u7d44\u7e54\u306e\u77f3\u7070\u5316\u304c\u8d77\u3053\u308a\u3001\u5fc3\u8840\u7ba1\u3084\u814e\u81d3\u306b\u969c\u5bb3\u304c\u8d77\u3053\u308b\u3002\u814e\u7d50\u77f3\u306e\u983b\u5ea6\u304c\u5897\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <br><br>\u904e\u5270\u30d3\u30bf\u30df\u30f3D\u306b\u3088\u308b\u5065\u5eb7\u88ab\u5bb3 <br>\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08NCI\uff09\u306b\u3088\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6bd2\u6027\u3068\u3057\u3066\u306f\u3001\u98df\u6b32\u4e0d\u632f\u3001\u4f53\u91cd\u6e1b\u5c11\u3001\u591a\u5c3f\u3001\u4e0d\u6574\u8108\u306a\u3069\u306e\u975e\u7279\u7570\u7684\u306a\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3055\u3089\u306b\u6df1\u523b\u306a\u3053\u3068\u306b\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u3001\u8840\u7ba1\u3084\u7d44\u7e54\u306e\u77f3\u7070\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u306e\u5f8c\u3001\u5fc3\u81d3\u3001\u8840\u7ba1\u3001\u814e\u81d3\u306b\u640d\u50b7\u3092\u4e0e\u3048\u308b\u3002\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u3088\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\uff081,000 mg \/\u65e5\uff09\u3068\u30d3\u30bf\u30df\u30f3D\uff08400 IU\u3001\u307e\u305f\u306f10\u03bcg\uff09\u306e\u4e21\u65b9\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4f7f\u7528\u306f\u30017\u5e74\u9593\u3067\u814e\u7d50\u77f3\u306e\u30ea\u30b9\u30af\u304c17\uff05\u5897\u52a0\u3057\u305f\u3002\u4e00\u8cab\u3057\u3066500 nmol \/ L\uff08&gt; 200 ng \/ mL\uff09\u3092\u8d85\u3048\u308b\u8840\u6e05\u30d3\u30bf\u30df\u30f3D\uff0825\uff08OH\uff09D\uff09\u6fc3\u5ea6\u306f\u3001\u6f5c\u5728\u7684\u306b\u6bd2\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002 <br>\u904e\u5270\u306e\u65e5\u5149\u66b4\u9732\u306f\u3001\u4f53\u304c\u4f5c\u6210\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u91cf\u3092\u5236\u9650\u3059\u308b\u306e\u3067\u3001\u30d3\u30bf\u30df\u30f3D\u4e2d\u6bd2\u306e\u539f\u56e0\u306b\u306f\u306a\u3089\u306a\u3044\u3002 <br>\u4e0a\u9650\u3092\u8d85\u3048\u308b\u9577\u671f\u6442\u53d6\uff089\u6b73\u4ee5\u4e0a\u30674,000IU\/\u65e5\u3001\u307e\u305f\u306f100\u03bcg\/\u65e5\uff09\u306f\u3001\u5065\u5eb7\u3078\u306e\u60aa\u5f71\u97ff\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3002\u307b\u3068\u3093\u3069\u306e\u5831\u544a\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306e\u6bd2\u6027\u95be\u5024\u306f10,000\uff5e40,000 IU \/\u65e5\uff08250\uff5e1,000\u03bcg\/\u65e5\uff09\u3067\u3042\u308a\u3001\u8840\u6e0525\uff08OH\uff09D\u6fc3\u5ea6\u306f500\uff5e600 nmol \/ L\uff08200\uff5e240 ng \/ mL\uff09\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u300210,000 IU \/\u65e5\u672a\u6e80\uff08250\u03bcg\/\u65e5\u672a\u6e80\uff09\u306e1\u65e5\u6442\u53d6\u91cf\u3067\u306f\u6bd2\u6027\u306e\u75c7\u72b6\u306f\u8d77\u3053\u308a\u306b\u304f\u3044\u304c\u3001FNB\uff08\u7c73\u56fd\u98df\u4e8b\u6804\u990a\u59d4\u54e1\u4f1a\uff09\u306f\u3001\u5168\u56fd\u8abf\u67fb\u30c7\u30fc\u30bf\u3001\u89b3\u5bdf\u7814\u7a76\u3001\u304a\u3088\u3073\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u3068\u8840\u6e0525\uff08OH\uff09D\u30ec\u30d9\u30eb\u304c\u3055\u3089\u306b\u4f4e\u3044\u3068\u6709\u5bb3\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u65b0\u3057\u3044\u7d4c\u6642\u7684\u306a\u5065\u5eb7\u3078\u306e\u5f71\u97ff\u3092\u6307\u6458\u3057\u305f\u3002FNB\uff08\u7c73\u56fd\u98df\u4e8b\u6804\u990a\u59d4\u54e1\u4f1a\uff09\u306f\u3001\u3055\u3089\u306b\u4f4e\u3044\u8840\u6e05\u30ec\u30d9\u30eb\uff08\u7d0475\uff5e120 nmol \/ L\u307e\u305f\u306f30\uff5e48 ng \/ mL\uff09\u306f\u3059\u3079\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u306e\u5897\u52a0\u3001\u81b5\u81d3\u306a\u3069\u306e\u4e00\u90e8\u306e\u90e8\u4f4d\u3067\u306e\u304c\u3093\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3001\u9ad8\u9f62\u8005\u306e\u8ee2\u5012\u3084\u9aa8\u6298\u306e\u5897\u52a0\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u306e\u3068\u540c\u69d8\u306b\u3001\u7d04125\uff5e150 nmol \/ L\uff0850\uff5e60 ng \/ mL\uff09\u3092\u8d85\u3048\u308b\u8840\u6e0525\uff08OH\uff09D\u30ec\u30d9\u30eb\u306f\u907f\u3051\u308b\u3079\u304d\u3067\u3042\u308b\u3068\u7d50\u8ad6\u4ed8\u3051\u305f\u3002FNB\u59d4\u54e1\u4f1a\u306f\u30015,000 IU \/\u65e5\uff08125\u03bcg\/\u65e5\uff09\u306e\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u304c100\uff5e150 nmol \/ L\uff0840\uff5e60 ng \/ mL\uff09\u306e\u8840\u6e0525\uff08OH\uff09D\u6fc3\u5ea6\u3092\u9054\u6210\u3057\u305f\u304c\u3001\u305d\u308c\u4ee5\u4e0a\u306b\u306f\u306a\u3089\u306a\u3044\u7814\u7a76\u3092\u5f15\u7528\u3057\u305f\u3002\u3053\u306e\u6442\u53d6\u5024\u306b20\uff05\u306e\u4e0d\u78ba\u5b9f\u6027\u4fc2\u6570\u3092\u9069\u7528\u3059\u308b\u3068\u30014,000 IU\uff08100\u03bcg\uff09\u306e\u4e0a\u9650\u304c\u5f97\u3089\u308c\u3001FNB\u304c9\u6b73\u4ee5\u4e0a\u306e\u5b50\u4f9b\u3068\u5927\u4eba\u306b\u9069\u7528\u3057\u305f\u3002 <br>NCI\/Office of dietary suppliments\/ Fact Sheet for Health Professionals\/Vitamin D\u3000https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\u3000 Nov. 9. 2019\u3002 <br>20\/35\u3000Health risks from excessive vitamin D.<\/p>\n\n\n\n<p class=\"anchor\" id=\"hypocalcemia\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-MmL13 wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u4f4e\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u306e\u75c7\u72b6<\/h2><\/div>\n\n\n<p class=\"mb40\">\u30c6\u30bf\u30cb\u30fc\uff08\u7b4b\u8089\u306e\u3051\u3044\u308c\u3093\uff08\u75d9\u6523\uff09\uff09<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-normal-range\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z1AoPTg wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u6e96\u5024\uff08\u6b63\u5e38\u5024\uff09<\/h2><\/div>\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u6e96\u5024\uff08\u6b63\u5e38\u5024\uff09\u3000 <br>\u30d3\u30bf\u30df\u30f3D\u3068\u3057\u306625(OH)D\u3092\u6e2c\u5b9a\u3057\u3066\u3044\u308b\u30021ng\/mL\uff1d2.5nmol\/L<\/p>\n\n\n<div class=\"lazyblock-table-02-Z1nycLI wp-block-lazyblock-table-02\">\n\n<div class=\"table-02\">\n    \n        <table\n            class=\"colnum4\"\n             style=\"--col1-width-sp:20%\"                    >\n\n            <colgroup>\n                                                            <col style=\"width: 20%\">\n                                                                                <col style=\"width: 26.666666666667%\">\n                                                                                <col style=\"width: 26.666666666667%\">\n                                                                                <col style=\"width: 26.666666666667%\">\n                                                <\/colgroup>\n\n                        <thead>\n                <tr>\n                    \n                                                                    <th class=\"is-header\">\n                                                    <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">25(OH)D<\/p>                        <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">ng\/ml<\/p>                        <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">\uff4emol\/L<\/p>                        <\/th>\n                                    <\/tr>\n            <\/thead>\n            \n            <tbody>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\" rowspan=\"3\">\n                                    <p style=\"text-align: left\">\u65e5\u672c <br \/>BML<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">\u57fa\u6e96\u5024<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <div>\n<div>\n<div style=\"text-align: left\"><span class=\"text-edit\" style=\"color: #ff0000\" data-cacoo-text-style=\"{&quot;index&quot;:0,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:16,&quot;color&quot;:&quot;d2302f&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">30\uff5e100<\/span><\/div>\n<\/div>\n<\/div>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">75\uff5e250<\/span><\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u4e0d\u8db3\u72b6\u614b<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\u4ee5\u4e0a\uff5e30\u672a\u6e80<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">50\u4ee5\u4e0a\uff5e75\u672a\u6e80<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u6b20\u4e4f\u75c7<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\u672a\u6e80<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">50\u672a\u6e80<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\" rowspan=\"3\">\n                                    <p style=\"text-align: left\">\u7c73\u56fd <br \/>NCI<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">\u57fa\u6e96\u5024<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">20\u4ee5\u4e0a\uff5e50\u672a\u6e80<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <div>\n<div>\n<div style=\"text-align: left\"><span class=\"text-edit\" style=\"color: #ff0000\" data-cacoo-text-style=\"{&quot;index&quot;:0,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:16,&quot;color&quot;:&quot;d2302f&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">50\u4ee5\u4e0a\uff5e125\u672a\u6e80<\/span><\/div>\n<\/div>\n<\/div>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u4e0d\u5341\u5206<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">12\u4ee5\u4e0a\uff5e20\u672a\u6e80<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">30\u4ee5\u4e0a\uff5e50\u672a\u6e80<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u4e0d\u8db3<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">12\u672a\u6e80<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">30\u672a\u6e80<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\" rowspan=\"4\">\n                                    <p style=\"text-align: left\">Holick<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">\u63a8\u5968\u5024<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\"> 30\uff5e60<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">75\uff5e150<\/span><\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u57fa\u6e96\u5024<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\uff5e100<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">30\uff5e250<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u6b20\u4e4f<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\u672a\u6e80<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">50\u672a\u6e80<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u4e2d\u6bd2<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">150\u3092\u8d85\u3048\u308b<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">375\u3092\u8d85\u3048\u308b<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                            <\/tbody>\n\n            \n        <\/table>\n        <\/div>\n<\/div>\n\n\n<p class=\"mb40\">Holick. Vitamin D Deficiency. N Engl J Med 2007;357:266-81.<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-normal-rate\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-ZMfQU9 wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u6b63\u5e38\u8005\u306e\u6bd4\u7387<\/h2><\/div>\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u6b63\u5e38\u8005\u306fMiyamoto\u3089\u306b\u3088\u308b\u3068 20\uff05\u53f0\u3057\u304b\u5b58\u5728\u3057\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u4e0d\u8db3\u30fb\u6b20\u4e4f\u306f\u6c7a\u3057\u3066\u7a00\u3067\u306f\u306a\u3044\u3002 <br>\u65e5\u672c\u4eba\u306e\u30d3\u30bf\u30df\u30f3D\u5024 <br>\u30d3\u30bf\u30df\u30f3D\u3068\u3057\u306625(OH)D\u3092\u6e2c\u5b9a\u3057\u3066\u3044\u308b\u30021ng\/mL\uff1d2.5nmol\/L<\/p>\n\n\n<div class=\"lazyblock-table-02-Z1bkJdL wp-block-lazyblock-table-02\">\n\n<div class=\"table-02\">\n    \n        <table\n            class=\"colnum4\"\n             style=\"--col1-width-sp:20%\"                    >\n\n            <colgroup>\n                                                            <col style=\"width: 20%\">\n                                                                                <col style=\"width: 26.666666666667%\">\n                                                                                <col style=\"width: 26.666666666667%\">\n                                                                                <col style=\"width: 26.666666666667%\">\n                                                <\/colgroup>\n\n                        <thead>\n                <tr>\n                    \n                                                                    <th class=\"is-header\">\n                                                    <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">\u6b63\u5e38<\/p>                        <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">\u4e0d\u5341\u5206<\/p>                        <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">\u4e0d\u8db3<\/p>                        <\/th>\n                                    <\/tr>\n            <\/thead>\n            \n            <tbody>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\">\n                                    <p style=\"text-align: left\">25(OH)D <br \/>ng\/ml<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">30\uff5e100<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\u4ee5\u4e0a\uff5e30\u672a\u6e80<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\u672a\u6e80<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\">\n                                    <p style=\"text-align: left\">39\uff0d49\u6b73\u3000\u5973\u6027<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">21.0\uff05<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">47.4\uff05<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">31.6\uff05<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\">\n                                    <p style=\"text-align: left\">50\uff0d59\u6b73\u3000\u5973\u6027<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">24.7\uff05<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">48.3\uff05<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">27.0\uff05<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\">\n                                    <p style=\"text-align: left\">60\uff0d64\u6b73\u3000\u5973\u6027<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\"><span style=\"color: #ff0000\">27.7\uff05<\/span><\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">57.4\uff05<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">14.9\uff05<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                            <\/tbody>\n\n            \n        <\/table>\n        <\/div>\n<\/div>\n\n\n<p class=\"mb40\">Miyamoto T. et al. Keio J Med 65 (2) : 33\u201338, 2016<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-recommended\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-2a5o9o wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u63a8\u5968\u6442\u53d6\u91cf<\/h2><\/div>\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u63a8\u5968\u6442\u53d6\u91cf<\/p>\n\n\n\n<p class=\"has-text-align-right mt-20\">1\u03bcg\uff1d40IU<\/p>\n\n\n<div class=\"lazyblock-table-02-ZTNsqW wp-block-lazyblock-table-02\">\n\n<div class=\"table-02\">\n    \n        <table\n            class=\"colnum6\"\n             style=\"--col1-width-sp:20%\"                    >\n\n            <colgroup>\n                                                            <col style=\"width: 20%\">\n                                                                                <col style=\"width: 16%\">\n                                                                                <col style=\"width: 16%\">\n                                                                                <col style=\"width: 16%\">\n                                                                                <col style=\"width: 16%\">\n                                                                                <col style=\"width: 16%\">\n                                                <\/colgroup>\n\n                        <thead>\n                <tr>\n                    \n                                                                    <th class=\"is-header\">\n                                                    <\/th>\n                                                                    <th class=\"is-header\">\n                            <p style=\"text-align: left\">\u5bfe\u8c61<\/p>                        <\/th>\n                                                                            <th class=\"is-header\" colspan=\"2\">\n                                    <p style=\"text-align: left\">\u76ee\u5b89<\/p>                                <\/th>\n                                                                                        <th class=\"is-header\" colspan=\"2\">\n                                    <p style=\"text-align: left\">\u4e0a\u9650<\/p>                                <\/th>\n                                                <\/tr>\n            <\/thead>\n            \n            <tbody>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\" rowspan=\"3\">\n                                    <p style=\"text-align: left\">\u65e5\u672c<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">18\u6b73\u4ee5\u4e0a<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">5.5\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">220IU<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">100\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">4,000IU<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u598a\u5a66<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">7\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">280IU<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                                            <\/td>\n                                                                                <td class=\"is-right\">\n                                                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">\u6388\u4e73<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">8\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">320IU<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                                            <\/td>\n                                                                                <td class=\"is-right\">\n                                                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                                                                                                                    <th class=\"is-left is-col-accent\" rowspan=\"2\">\n                                    <p style=\"text-align: left\">\u7c73\u56fdNCI<\/p>                                <\/th>\n                                                    \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">9\uff5e70\u6b73<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">15\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">600IU<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">100\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">4,000IU<\/p>                            <\/td>\n                        \n                    \n                <\/tr>\n                                <tr>\n\n                    \n                        \n                        \n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">71\u6b73\u4ee5\u4e0a<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">20\u03bcg<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                <p style=\"text-align: left\">800IU<\/p>                            <\/td>\n                                                                                <td class=\"is-right\">\n                                                            <\/td>\n                                                                                <td class=\"is-right\">\n                                                            <\/td>\n                        \n                    \n                <\/tr>\n                            <\/tbody>\n\n            \n        <\/table>\n        <\/div>\n<\/div>\n\n\n<p class=\"mb30\">\u539a\u751f\u52b4\u50cd\u7701\u306b\u3088\u308b\u3068\u65e5\u672c\u4eba\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u306f\uff1a\u5e73\u5747\u5024\uff1a7.5\u03bcg\u3001\u6a19\u6e96\u504f\u5dee\uff1a8.0\u03bcg\u3001\u4e2d\u592e\u5024\uff1a3.8\u03bcg\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"mb30\">\u6ce8\uff09\u56fd\u6c11\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u5e73\u5747\u6442\u53d6\u91cf\u306f\u76ee\u5b89\u306b\u306f\u8db3\u308a\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u3067\u306f\u3001\u73fe\u5b9f\u7684\u306b\u306f\u591a\u304f\u306e\u4eba\u3001\u7279\u306b\u65e5\u306b\u5f53\u305f\u3089\u306a\u3044\u4eba\u3084\u9ad8\u9f62\u8005\u3067\u4e0d\u8db3\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002 <br>\u65e5\u672c\u306e\u30d3\u30bf\u30df\u30f3D\u63a8\u5968\u6442\u53d6\u91cf\u306f1\u65e55.5\u03bcg\u3060\u304c\u3001\u4e0a\u9650\u306f1\u65e5100\u03bcg\u3068\u3057\u3066\u3044\u308b\u3002\u6d77\u5916\u306f\u3082\u3068\u3088\u308a\u56fd\u5185\u3067\u591a\u304f\u306e\u4f4f\u6c11\u304c\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u3084\u4e0d\u8db3\u306b\u9665\u3063\u3066\u3044\u308b\u73fe\u72b6\u3092\u8003\u3048\u308b\u3068\u30011\u65e55.5\u03bcg\u306e\u6442\u53d6\u306f\u4e0d\u5341\u5206\u3067\u3042\u308d\u3046\u3002\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u591a\u304f\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u30d3\u30bf\u30df\u30f3D\u542b\u6709\u91cf\u3092\u898b\u308b\u3068\u30011\u65e55.5\u03bcg\u3068\u8a18\u8f09\u3057\u3066\u3042\u308a\u3001\u5fc5\u8981\u91cf\u306e100\uff05\u3092\u5145\u8db3\u3057\u3066\u3044\u308b\u3068\u8a18\u8f09\u3057\u3066\u3044\u308b\u3002 <br>\u81ea\u5206\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u3069\u306e\u7a0b\u5ea6\u304b\u77e5\u3089\u305a\u306b\u3001\u4e0d\u8db3\u304b\u6b20\u4e4f\u304b\u5145\u8db3\u304b\u3092\u5224\u65ad\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002\u307e\u305f\u6442\u53d6\u3059\u308b\u306a\u3089\u30011\u65e5\u4f55\u03bcg\u3092\u6442\u53d6\u3059\u308b\u304b\u306b\u3088\u3063\u3066\u30d3\u30bf\u30df\u30f3D\u304c\u5145\u8db3\u3067\u304d\u308b\u304b\u304c\u6c7a\u307e\u3063\u3066\u304f\u308b\u3060\u308d\u3046\u3002<\/p>\n\n\n\n<p>\u5ca1\u5d0e\u3000\u4eae\uff0e\u65e5\u8001\u533b\u8a8c\u30002009\uff1a46\uff1b125-7.<\/p>\n\n\n<div class=\"lazyblock-list-05-jidAg mb40 wp-block-lazyblock-list-05\"><div class=\"list-05\">\n    <ul>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u3092\u542b\u3080\u98df\u54c1\u306f\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u88dc\u7d66\u3059\u308b\u306b\u306f\u65e5\u5149\u306b\u5f53\u305f\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<br \/>\uff08\u6ce8\uff1a\u65e5\u5149\u306b\u5f53\u305f\u308b\u30de\u30a4\u30ca\u30b9\u9762\u3067\u306f\u3001\u76ae\u819a\u306e\u8001\u5316\u3001\u76ae\u819a\u304c\u3093\u306e\u5897\u52a0\u3001\u71b1\u4e2d\u75c7\u306a\u3069\u306e\u554f\u984c\u304c\u3042\u308b\uff09<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306e\u4e88\u9632\u306b\u306f\u3001\u9ad8\u9f62\u8005\u3067\u306f\u5c11\u306a\u304f\u3068\u30821\u65e510\u03bcg\u3001\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u304c\u3042\u308c\u307020\u03bcg\u7a0b\u5ea6\u306f\u5fc5\u8981\u3067\u3042\u308d\u3046\u3002<\/p><\/li>\n        <\/ul>\n<\/div>\n<\/div>\n\n\n<p>\u79cb\u8449\u76f4\u5fd7\u3001\u6d66\u5cf6\u5145\u4f73\u3089\uff0eClin Cancer Res. 2018 Sep 1;24(17):4089-97.<\/p>\n\n\n<div class=\"lazyblock-list-05-ZrqyvR mb40 wp-block-lazyblock-list-05\"><div class=\"list-05\">\n    <ul>\n            <li><p>\u6bce\u65e530\u03bcg\u30011\u5e74\u9593\u306e\u30d3\u30bf\u30df\u30f3D\u5185\u670d\u7fa4\u3067\u306f\u3001 \u8840\u6db2\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\uff0825\uff0d\u30cf\u30a4\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\uff09\u6fc3\u5ea6\u306f\u5e73\u574721ng\/mL\u304b\u3089\u5e73\u574739ng\/mL\u3068\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u4e0a\u6607\u3057\u305f\u3002\uff08\u6ce8\uff1a\u65e5\u5149\u306b\u5f53\u305f\u308b\u30de\u30a4\u30ca\u30b9\u9762\u3067\u306f\u3001\u76ae\u819a\u306e\u8001\u5316\u3001\u76ae\u819a\u304c\u3093\u306e\u5897\u52a0\u3001\u71b1\u4e2d\u75c7\u306a\u3069\u306e\u554f\u984c\u304c\u3042\u308b\uff09<\/p><\/li>\n            <li><p>\u30d3\u30bf\u30df\u30f3D\u306e\u30d7\u30e9\u30bb\u30dc\u5185\u670d\u7fa4\u3067\u306f\u300122\u304b\u308924ng\/mL\u3068\u7d71\u8a08\u7684\u306b\u306f\u4e0d\u5909\u3067\u3042\u3063\u305f\u3002<\/p><\/li>\n            <li><p>\u8840\u6e05\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u306f\u4e21\u7fa4\u3067\u4e0d\u5909\u3067\u3042\u3063\u305f\u3002 \u3000 <br \/>\uff08\u65e5\u672c\uff09\u30d3\u30bf\u30df\u30f3D\u306e18\u6b73\u4ee5\u4e0a\u306e\u6442\u53d6\u306e\u4e0a\u9650\u306f\u3001100\u03bcg\uff084,000IU\uff09\u3067\u3042\u308b\u3002<\/p><\/li>\n        <\/ul>\n<\/div>\n<\/div>\n\n\n<p class=\"mb40\">\u30d3\u30bf\u30df\u30f3D\u3068\u5065\u5eb7\uff1a\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\uff08NCI\uff09\u306b\u3088\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u306e\u5897\u52a0\u306b\u5fdc\u3058\u3066\u8840\u6e0525\uff08OH\uff09D\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3059\u308b\u304c\u3001\u305d\u306e\u95a2\u4fc2\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u3044\u7406\u7531\u306b\u3088\u308a\u975e\u7dda\u5f62\u3067\u3042\u308b\u3002\u5897\u52a0\u306f\u3001\u4f8b\u3048\u3070\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u8840\u6e05\u30ec\u30d9\u30eb\u3068\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6301\u7d9a\u6642\u9593\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3002\u8840\u6e0525\uff08OH\uff09D\u3092&gt; 50 nmol \/ L\uff0820ng\/ml\uff09\u306b\u5897\u3084\u3059\u306b\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3&lt;50 nmol \/ L\uff0820ng\/ml\uff09\u304b\u3089\u30ec\u30d9\u30eb\u3092\u4e0a\u3052\u308b\u3088\u308a\u3082\u591a\u304f\u306e\u30d3\u30bf\u30df\u30f3D\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u6295\u4e0e\u91cf\u304c1\u65e5\u3042\u305f\u308a1,000 IU\u672a\u6e80\uff0825\u03bcg\u672a\u6e80\uff09\u306e\u5834\u5408\u3001\u8840\u6e0525\uff08OH\uff09D\u304c\u6025\u6fc0\u306b\u5897\u52a0\u3059\u308b\u3002\u3088\u308a\u9ad8\u3044\u3001\u3088\u308a\u5e73\u5766\u306a\u53cd\u5fdc\u306f\u3001\u3088\u308a\u9ad8\u30441\u65e5\u7528\u91cf\u3067\u898b\u3089\u308c\u308b\u3002\u7528\u91cf\u304c\u22651,000IU \/\u65e5\uff0825\u03bcg\/\u65e5\u4ee5\u4e0a\uff09\u3067\u3042\u308b\u5834\u5408\u3001\u8840\u6e0525\uff08OH\uff09D\u306e\u4e0a\u6607\u306f\u3001\u6442\u53d6\u91cf40 IU\uff081\u03bcg\uff09\u3054\u3068\u306b\u7d041 nmol \/ L\u3067\u3042\u308b\u3002600 IU \/\u65e5\u4ee5\u4e0b\uff0815\u03bcg\/\u65e5\u4ee5\u4e0b\uff09\u306e\u7528\u91cf\u3067\u306e\u7814\u7a76\u3067\u306f\u3001\u8840\u6e0525\uff08OH\uff09D\u306e\u4e0a\u6607\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u309240 IU\uff081\u03bcg\uff09\u6442\u53d6\u3059\u308b\u3054\u3068\u306b\u7d042.3 nmol \/ L\uff080.92ng\/ml\uff09\u3067\u3042\u3063\u305f\u3002 <br>2011\u5e74\u3001\u7c73\u56fd\u5185\u5206\u6ccc\u5b66\u4f1a\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u81e8\u5e8a\u5b9f\u8df5\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u767a\u884c\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3001\u9aa8\u3001\u7b4b\u8089\u4ee3\u8b1d\u306b\u5bfe\u3059\u308b\u3053\u306e\u30d3\u30bf\u30df\u30f3\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u306b\u300125\uff08OH\uff09D\u306e\u671b\u307e\u3057\u3044\u8840\u6e05\u6fc3\u5ea6\u306f&gt; 75 nmol \/ L\uff08&gt; 30 ng \/ ml\uff09\u3067\u3042\u308b\u3068\u8ff0\u3079\u305f\u3002\u307e\u305f\u300125\uff08OH\uff09D\u306e\u8840\u6e05\u30ec\u30d9\u30eb\u309275 nmol \/ L\uff0830 ng \/ ml\uff09\u3092\u8d85\u3048\u3066\u4e00\u8cab\u3057\u3066\u4e0a\u6607\u3055\u305b\u308b\u306b\u306f\u3001\u6210\u4eba\u3067\u306f\u5c11\u306a\u304f\u3068\u30821,500-2,000 IU \/\u65e5\uff0837.5-50\u03bcg\/\u65e5\uff09\u5b50\u4f9b\u3068\u9752\u5c11\u5e74\u3067\u306f\u30d3\u30bf\u30df\u30f31,000 IU\/\u65e5\u304c\u5fc5\u8981\u3067\u3042\u308d\u3046\u3002 <br>NCI\/Office of dietary suppliments\/ Fact Sheet for Health Professionals\/Vitamin D\u3000https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\u3000 Nov. 9. 2019. <br>14\/35\u3000Vitamin D and health.<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-basics\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z1BPYGU wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u790e\u77e5\u8b58<\/h2><\/div>\n\n<div class=\"lazyblock-list-02-Z1ElsqW mb40 wp-block-lazyblock-list-02\"><div class=\"list-02\">\n    <ol>\n            <li>\n            <div>\n<div>\n<div><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:2,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u30d3\u30bf\u30df\u30f3D\u2082\u306f\u30d3\u30bf\u30df\u30f3D\u2082\u304b\u3089\u30d3\u30bf\u30df\u30f3D\u2087\u307e\u3067\u3042\u308b\u3002<\/span><\/div>\n<\/div>\n<\/div>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u2081\u306f\u8aa4\u3063\u305f\u5316\u5408\u7269\u306b\u547d\u540d\u3057\u3066\u3044\u305f\u306e\u3067\u3001\u305d\u306e\u5f8c\u53d6\u308a\u6d88\u3057\u306b\u306a\u308a\u3001\u5b58\u5728\u3057\u306a\u3044\u3002<\/p>        <\/li>\n            <li>\n            <p>\u751f\u7406\u5b66\u7684\u306b\u91cd\u8981\u306a\u306e\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u2082\uff08\u30a8\u30eb\u30b4\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u3068\u30d3\u30bf\u30df\u30f3D\u2083\uff08\u30b3\u30ec\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u306e\u307f\u3067\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u2082\u3068\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u540c\u7b49\u306e\u4f5c\u7528\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u306e\u4f5c\u7528\u306f\u8178\u7ba1\u304b\u3089\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3057\u3001\u9069\u5207\u306a\u8840\u6e05\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30ea\u30f3\u306e\u6fc3\u5ea6\u3092\u7dad\u6301\u3059\u308b\u3002\u9aa8\u306e\u77f3\u7070\u5316\uff08\u30ab\u30eb\u30b7\u30a6\u30e0\u6c88\u7740\uff09\u3092\u8d77\u3053\u3057\u3001\u9aa8\u306e\u6210\u9577\u3084\u518d\u69cb\u7bc9\u306b\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u306f\u30ab\u30c4\u30aa\u3001\u30a2\u30f3\u30b3\u30a6\u809d\u3001\u30b5\u30b1\u306a\u3069\u306e\u9b5a\u985e\u3001\u30ad\u30af\u30e9\u30b2\u3001\u30b7\u30a4\u30bf\u30b1\u306a\u3069\u306e\u30b7\u30a4\u30bf\u30b1\u985e\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u306f\u5b50\u4f9b\u306e\u30af\u30eb\u75c5\u4e88\u9632\u3084\u9aa8\u8edf\u5316\u75c7\u3092\u4e88\u9632\u3057\u3001\u8001\u4eba\u306e\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3092\u9632\u3050\u3002<\/p>        <\/li>\n            <li>\n            <p>\u6625\u304b\u3089\u590f\u306b\u304b\u3051\u3066\u3001\u7d2b\u5916\u7dda\u304c\u591a\u3044\u6b63\u5348\u9803\u306b30\u5206\u7a0b\u3001\u9854\u3084\u624b\u8db3\u3092\u65e5\u5149\u306b\u3055\u3089\u3059\u3053\u3068\u3067\u3001\u5341\u5206\u306a\u30d3\u30bf\u30df\u30f3D\u304c\u76ae\u819a\u3067\u751f\u6210\u3055\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u2083\u306e\u6295\u4e0e\u91cf\u3084\u6442\u53d6\u91cf\u306e\u5358\u4f4d\uff1a1\u03bc\uff47\uff1d40IU<br \/>\u3000 1. \uff08\u03bc\uff47\uff1d\u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\uff1a100\u4e07\u5206\u306e1\u30b0\u30e9\u30e0\uff09<br \/>\u3000 2. \uff08IU\uff1d\u56fd\u969b\u5358\u4f4d\uff1ainternational unit)<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u6db2\u4e2d\u306e\u6fc3\u5ea6\u306e\u4ee3\u308f\u308a\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6e2c\u5b9a\u306f25\u4f4d\u6c34\u9178\u5316\u30d3\u30bf\u30df\u30f3D\u2083\uff0825(OH)D\u2083\uff09\u306e\u6fc3\u5ea6\u3092\u4f7f\u7528\u3059\u308b\uff1a1ng\/mL\uff1d2.5nmol\/L<br \/>\u3000 1. \uff08nmol\/L\uff1d\uff11\u30ea\u30c3\u30c8\u30eb\u4e2d\u306b\uff11\u30ca\u30ce\u30e2\u30eb\uff08\uff11\uff10\u5104\u5206\u306e1\u30e2\u30eb\uff09\uff09<br \/>\u3000 2. \uff08ng\/mL\uff1d\uff11cc\u5f53\u305f\u308a\u306e\u30ca\u30ce\u30b0\u30e9\u30e0\uff08\uff11\uff10\u5104\u5206\u306e1\u30b0\u30e9\u30e0\uff09\uff09<\/p>        <\/li>\n            <li>\n            <p>\u4ee5\u4e0b\u306f\u540c\u3058\u3082\u306e\u3067\u3042\u308b\uff1a<br \/>\u3000 1. 25\u4f4d\u6c34\u9178\u5316\u30d3\u30bf\u30df\u30f3D\u2083<br \/>\u3000 2. 25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083<br \/>\u3000 3. 25(OH)D\u2083<br \/>\u3000 4. \u30ab\u30eb\u30b7\u30c7\u30a3\u30aa\u30fc\u30eb\uff08calcidiol\uff09<\/p>        <\/li>\n            <li>\n            <p>25\uff08OH\uff09D\u2083\u8840\u4e2d\u6fc3\u5ea6\u306e\u57fa\u6e96\u5024<br \/>\u3000 \uff08\u30a2\uff09\u65e5\u672c\u306e\u57fa\u6e96\u5024\u306f30-100\uff4eg\/mL <br \/>\u3000 \uff08\u30a4\uff09\u4e0d\u8db3\u306f\u3001\u5b50\u4f9b\u306f\u304f\u308b\u75c5\u3001\u9aa8\u8edf\u5316\u75c7\u3001\u5927\u4eba\u306f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u5371\u967a\u3042\u308a\u3002<br \/>\u3000 \uff08\u30a6\uff09\u904e\u5270\u306f\u3001\u526f\u4f5c\u7528\u306e\u5371\u967a\u3042\u308a\u3002<br \/>\u3000 \u3000 \u3000 1. 25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D \u307e\u305f\u306f25(OH)D\u2083\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e25\u4f4d\u306b\u6c34\u9178\u57fa\uff08\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u3001-OH\uff09\u304c\u4ed8\u7740\u3057\u305f\u7269\u8cea\u3002<\/p>        <\/li>\n            <li>\n            <p>\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3A\u3001 D\u3001 E\u3001 K\u304c\u3042\u308b\u3002\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306f\u591a\u3059\u304e\u308b\u3068\u904e\u5270\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u306f\u65e5\u672c\u3067\u306f\u6210\u4eba\u3067\u3001\u76ee\u5b895.5\u03bcg\u3001\u4e0a\u9650100\u03bcg\u3001\u307e\u305f\u306f\u76ee\u5b89220IU\u3001\u4e0a\u96504,000IU\u3092\u52e7\u3081\u3066\u3044\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u306f\u7c73\u56fd\u3067\u306f\u6210\u4eba\u306b15\u03bcg \u3001600IU\u3092\u52e7\u3081\u3066\u3044\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D2\u306f\u690d\u7269\u7531\u6765<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D2\u306f\u9175\u6bcd\u304b\u3089\u5f97\u3089\u308c\u308b\u30a8\u30eb\u30b4\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u7d2b\u5916\u7dda\u7167\u5c04\u3068\u71b1\u7570\u5316\u53cd\u5fdc\u3067\u5408\u6210\u3055\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u65e5\u672c\u4eba\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\uff1a\u5e73\u5747\u5024\uff1a7.5\u03bcg\u3001\u6a19\u6e96\u504f\u5dee\uff1a8.0\u03bcg\u3001\u4e2d\u592e\u5024\uff1a3.8\u03bcg<\/p>        <\/li>\n        <\/ol>\n<\/div>\n<\/div>\n\n\n<p class=\"anchor\" id=\"vitamin-d3-metabolism\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-ZplJaO wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3D\u2083\u306e\u4f53\u5185\u4ee3\u8b1d<\/h2><\/div>\n\n<div class=\"lazyblock-list-02-1vQXrN mb30 wp-block-lazyblock-list-02\"><div class=\"list-02\">\n    <ol>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3\uff24\u2083\u306f\u4eba\u306e\u76ae\u819a\u3067\u4f5c\u3089\u308c\u3001\u4f53\u4e2d\u3092\u5faa\u74b0\u3059\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>7-\u30c7\u30d2\u30c9\u30ed\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff087-dehydrocholesterol\uff09\u306f\u30d3\u30bf\u30df\u30f3D\u2083\u306e\u524d\u99c6\u4f53\uff08\u30d7\u30ed\u30d3\u30bf\u30df\u30f3D\u2083\uff09\u3067\u3042\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u30a2\u30bb\u30c1\u30eb CoA\uff08\u30a2\u30bb\u30c1\u30eb\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0\uff21\uff1a\u30a2\u30bb\u30c1\u30eb\u88dc\u9175\u7d20A\uff09\u304b\u30897-\u30c7\u30d2\u30c9\u30ed\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3067\u304d\u308b\u30027-\u30c7\u30d2\u30c9\u30ed\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u9084\u5143\u3055\u308c\u308b\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u306a\u308a\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306b\u306a\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u76ae\u819a\u3067\u306e\u4ee3\u8b1d\uff097-\u30c7\u30d2\u30c9\u30ed\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u8868\u76ae\u306b\u591a\u304f\u542b\u307e\u308c\u3001\u592a\u967d\u5149\u306e\u7167\u5c04\u3067\u30d7\u30ec\u30d3\u30bf\u30df\u30f3D\u2083\u306b\u5909\u5316\u3059\u308b\u3002\u30d7\u30ec\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u4f53\u6e29\u3067\u30d3\u30bf\u30df\u30f3D (\u30b3\u30ec\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff1acholecalciferol)\u306b\u5909\u5316\u3059\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u8840\u7ba1\u5185\u306e\u79fb\u52d5\uff09\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u6c34\u306b\u306f\u6eb6\u3051\u306a\u3044\u306e\u3067\u3001\u8840\u6db2\u3092\u5faa\u74b0\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u305f\u3093\u3071\u304f\u8cea\uff08DBP\uff1a vitamin D binding protein\uff09\u306b\u7d50\u5408\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u2083\u2015\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u305f\u3093\u3071\u304f\u8cea\u3068\u306a\u308a\u3001\u8840\u7ba1\u5185\u306e\u8840\u6d41\u3092\u6d41\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u809d\u81d3\u3067\u306e\u4ee3\u8b1d\uff09\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u809d\u81d3\u306b\u884c\u304f\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u2083\u306e25\u306e\u4f4d\u7f6e\u306b\u6c34\u9178\u57fa\uff08\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u3001-OH\uff09\u304c\u4ed8\u7740\u3057\u300125-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\uff0825(OH)D\u2083\u3001\u30ab\u30eb\u30b7\u30c7\u30a3\u30aa\u30fc\u30eb\u3001calcidiol\uff09\u306b\u4ee3\u8b1d\u3055\u308c\u3001\u8840\u4e2d\u306b\u51fa\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u8840\u7ba1\u5185\u306e\u79fb\u52d5\uff0925-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\uff0825(OH)D\u2083\uff09\u306f\u6c34\u306b\u306f\u6eb6\u3051\u306a\u3044\u306e\u3067\u3001\u8840\u6db2\u3092\u5faa\u74b0\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u305f\u3093\u3071\u304f\u8cea\uff08DBP\uff1a vitamin D binding\u3000 \u3000 protein\uff09\u306b\u7d50\u5408\u3057\u300125-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\u2015\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u305f\u3093\u3071\u304f\u8cea\u3068\u306a\u308a\u3001\u8840\u7ba1\u5185\u306e\u8840\u6d41\u3092\u6d41\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u814e\u81d3\u3067\u306e\u4ee3\u8b1d\uff0925-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u814e\u81d3\u306b\u884c\u304f\u3068\u300125-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\u306b\u3001\u3055\u3089\u306b1\u03b1\u306e\u4f4d\u7f6e\u306b\u6c34\u9178\u57fa\uff08\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u3001-OH\uff09\u304c\u4ed8\u7740\u3057\u30011\u03b1,25- \u3000\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\uff081,25(OH)2D3 \u3001\u30ab\u30eb\u30b7\u30c8\u30ea\u30aa\u30fc\u30eb\u3001calcitriol\uff09\u306b\u4ee3\u8b1d\u3055\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u8840\u7ba1\u5185\u306e\u79fb\u52d5\uff091\u03b1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\uff081,25(OH)2D3\uff09\u306f\u4f53\u5185\u3067\u6700\u3082\u50cd\u304f\u30d3\u30bf\u30df\u30f3D\u3067\u3042\u308a\u3001\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3068\u3082\u8a00\u308f\u308c\u3066\u3044\u308b\u30021\u03b1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u6c34\u306b\u306f\u6eb6\u3051\u306a\u3044\u306e\u3067\u3001\u8840\u6db2\u3092\u5faa\u74b0\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u305f\u3093\u3071\u304f\u8cea\uff08DBP\uff1a vitamin D binding protein\uff09\u306b\u7d50\u5408\u3057\u30011\u03b1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\u2015\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u305f\u3093\u3071\u304f\u8cea\u3068\u306a\u308a\u3001\u8840\u7ba1\u5185\u3092\u6d41\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>1\u03b1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\uff081,25(OH)2D3\uff09\u306f\u8178\u7ba1\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30ea\u30f3\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3059\u308b\u3002\u307e\u305f\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3PTH\u306e\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3PTH\u306f1\u03b1\u6c34\u9178\u5316\u9175\u7d20\u3092\u4fc3\u9032\u30571\u03b1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\uff081,25(OH)2D3\uff09\u3092\u4f5c\u6210\u3059\u308b\u30021\u03b1\u6c34\u9178\u5316\u9175\u7d20\u306f\u4f4e\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u3084\u4f4e\u30ea\u30f3\u8840\u75c7\u306b\u3088\u3063\u3066\u3082\u4fc3\u9032\u3055\u308c\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>\uff08\u4f53\u5185\uff09\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u306f\u4f53\u5185\u306e\u3059\u3079\u3066\u306e\u7d44\u7e54\u3084\u7d30\u80de\u306e\u6838\u5185\u306b\u5b58\u5728\u3059\u308b\u3002<\/p>        <\/li>\n            <li>\n            <p>1\u03b1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u2083\u306f\u6a19\u7684\u7d30\u80de\u306e\u7d30\u80de\u6838\u5185\u306b\u5b58\u5728\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff1avitamin D receptor\uff09\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u4f9d\u5b58\u6027\u305f\u3093\u3071\u304f\u8cea\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3001\u5fc5\u8981\u306a\u4ed5\u4e8b\u3092\u884c\u3046\u3002\u4f53\u306e\u5168\u3066\u306e\u7d30\u80de\u304c\u6a19\u7684\u7d30\u80de\u3067\u3001\u5168\u3066\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u666e\u904d\u7684\u306a\u4ed5\u4e8b\u3092\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>        <\/li>\n        <\/ol>\n<\/div>\n<\/div>\n\n<div class=\"lazyblock-table-01-1tFKPf mb40 wp-block-lazyblock-table-01\"><div class=\"table-01\">\n    <table class=\"table-01__table\">\n                <tbody>\n                            <tr>\n                    <th style=\"--width_pc:20%; --width_sp:20%;\"><p style=\"text-align: left\">\u52d5\u7269<\/p><\/th>\n                    <td><p>7- \u30c7\u30d2\u30c9\u30ed\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3000\u3000\u3000\u21d2\u3000\u3000\u3000\u7d2b\u5916\u7dda\u3068\u4f53\u6e29\u3000\u3000\u3000\u21d2\u3000\u3000\u3000\u30d3\u30bf\u30df\u30f3D\u2083<br \/>\u3000\uff08\u30d3\u30bf\u30df\u30f3D\u2083\u306e\u524d\u99c6\u4f53\uff09\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\uff08\u30b3\u30ec\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff09<br \/>\u3000\uff08\u30d7\u30ed\u30d3\u30bf\u30df\u30f3D\u2083\uff09<\/p><\/td>\n                <\/tr>\n                            <tr>\n                    <th style=\"--width_pc:20%; --width_sp:20%;\"><p style=\"text-align: left\">\u690d\u7269<\/p><\/th>\n                    <td><p>\u30a8\u30eb\u30b4\u30b9\u30c6\u30ed\u30fc\u30eb\u3000\u3000\u3000\u21d2\u3000\u3000\u3000\u7d2b\u5916\u7dda\u3068\u71b1\u3000\u3000\u3000\u21d2\u3000\u3000\u3000\u30d3\u30bf\u30df\u30f3D\u2082<\/p><\/td>\n                <\/tr>\n                    <\/tbody>\n    <\/table>\n<\/div><\/div>\n\n\n<p class=\"anchor\" id=\"references\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-ZLyjQb wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u53c2\u8003\u6587\u732e<\/h2><\/div>\n\n<div class=\"lazyblock-list-02-Z1bGJi7 mb40 wp-block-lazyblock-list-02\"><div class=\"list-02\">\n    <ol>\n            <li>\n            <p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:2,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">NCI\/Office of dietary suppliments\/ Fact Sheet for Health Professionals\/Vitamin D \u3000 <br \/><\/span><a class=\"cacoo-text-link\" href=\"https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/\" target=\"_blank\" rel=\"noopener\" data-cacoo-text-link=\"{&quot;type&quot;:1,&quot;to&quot;:&quot;https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/&quot;,&quot;startIndex&quot;:86,&quot;endIndex&quot;:147}\"><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:86,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;14126f&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:true,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/<\/span><\/a><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:148,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;14126f&quot;,&quot;bold&quot;:true,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u3000<\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:149,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">Nov.9,2018<\/span><\/p>        <\/li>\n            <li>\n            <p>Vuolo L1, Di Somma C, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol (Lausanne). 2012 Apr 23;3:58.<\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u3002\u30d3\u30bf\u30df\u30f3\u7dcf\u5408\u8f9e\u5178\u3002pp44-81\u3002\u65e5\u672c\u30d3\u30bf\u30df\u30f3\u5b66\u4f1a\u7de8\u96c6\u3002\u7b2c\uff13\u5237\u3001\u671d\u5009\u66f8\u5e97\u3002\u6771\u4eac2016\u5e74\u3002<\/p>        <\/li>\n            <li>\n            <p>\u698a\u3000\u5229\u884c\u3002\u4ee3\u8b1d\u7814\u7a76\u306b\u57fa\u3065\u304f\u30d3\u30bf\u30df\u30f3D\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u518d\u8003\u3002\u751f\u5316\u5b66\u300087\uff1a4\uff1b438-444\u30012015.<\/p>        <\/li>\n            <li>\n            <p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:3,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u30d3\u30bf\u30df\u30f3D\u3002\u300c\u7d71\u5408\u533b\u7642\u300d\u60c5\u5831\u767a\u4fe1\u30b5\u30a4\u30c8\u3002\u539a\u751f\u52b4\u50cd\u7701\u300c\u7d71\u5408\u533b\u7642\u300d\u306b\u4fc2\u308b\u60c5\u5831\u767a\u4fe1\u7b49\u63a8\u9032\u4e8b\u696d\u3002<br \/><\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:50,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u00a0http:\/\/www.ejim.ncgg.go.jp\/pro\/overseas\/c03\/17.html<\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:101,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u3000<\/span><\/p>        <\/li>\n            <li>\n            <p><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:3,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u300c\u5065\u5eb7\u98df\u54c1\u300d\u306e\u5b89\u5168\u6027\u30fb\u6709\u52b9\u6027\u60c5\u5831\u3002<\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:20,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;14126f&quot;,&quot;bold&quot;:true,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u3000<\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:21,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">https:\/\/hfnet.nibiohn.go.jp\/contents\/detail221.html<\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:72,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;14126f&quot;,&quot;bold&quot;:true,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u3000<\/span><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:73,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">2019.6.23<\/span><\/p>        <\/li>\n            <li>\n            <p>\u30d3\u30bf\u30df\u30f3D\u306e\u50cd\u304d\u30681\u65e5\u306e\u6442\u53d6\u91cf\u3002\u5065\u5eb7\u9577\u5bff\u30cd\u30c3\u30c8\u3002https:\/\/www.tyojyu.or.jp\/net\/kenkou-tyoju\/eiyouso\/vitamin-d.html\u30002019.2.1<\/p>        <\/li>\n            <li>\n            <p>Holick. Vitamin D Deficiency. N Engl J Med 2007;357:266-81.<\/p>        <\/li>\n            <li>\n            <p>\u5185\u79d1\u5b66\u3002\u9ed2\u5ddd\u3000\u6e05\u3089\u7de8\u96c6\u3002\u6771\u4eac\u3001\u6587\u5149\u5802\u30021999\u5e74\u3002<\/p>        <\/li>\n            <li>\n            <p>Miyamoto T et al. Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years.Keio J Med 65 (2) : 33-38, 2016<\/p>        <\/li>\n            <li>\n            <p>Pilz et al. Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper. Front. Endocrinol., 17 July 2018 |<br \/>https:\/\/doi.org\/10.3389\/fendo.2018.00373.<\/p>        <\/li>\n            <li>\n            <p>\u5e73\u7530\u7d50\u559c\u7dd2\u76e3\u4fee\u3002\u7af9\u5185\u9756\u535a\u3001\u6749\u672c\u5229\u55e3\u3001\u6210\u702c\u5149\u6804\u7de8\u96c6\u3002\u7532\u72b6\u817a\u30fb\u9aa8\u4ee3\u8b1d\u75be\u60a3\u8a3a\u7642\u30de\u30cb\u30e5\u30a2\u30eb\u3002\u6539\u8a02\u7b2c2\u7248\u3002\u8a3a\u65ad\u3068\u6cbb\u7642\u793e\u3002\u6771\u4eac\u30022015.1.5\u3002<\/p>        <\/li>\n        <\/ol>\n<\/div>\n<\/div>\n\n\n<p class=\"anchor\" id=\"takaki-kanehiro\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-jwTTa wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u30d3\u30bf\u30df\u30f3\u306e\u7236\u3001\u9ad8\u6728\u517c\u5bdb<\/h2><\/div>\n\n\n\n<div class=\"lazyblock-year-Kl8cz mb30 wp-block-lazyblock-year\">\n<div class=\"timeline-history\">\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1853\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t<span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:0,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u30da\u30ea\u30fc\u304c\u6765\u822a\u3057\u3001\u305d\u306e\u5f8c\u306b\u96c4\u85e9\u3067\u8fd1\u4ee3\u7684\u6d77\u8ecd\u304c\u59cb\u307e\u3063\u305f\u3002<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1868\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t\u738b\u653f\u5fa9\u53e4\u306e\u5927\u53f7\u4ee4\u304c\u767a\u305b\u3089\u308c\u660e\u6cbb\u65b0\u653f\u5e9c\u304c\u6a39\u7acb\u3057\u305f\u3002\u65e5\u672c\u3067\u306f\u30d3\u30bf\u30df\u30f3B1\u6b20\u4e4f\u306b\u3088\u308a\u767a\u75c7\u3059\u308b\u811a\u6c17\u304c\u731b\u5a01\u3092\u632f\u308b\u3063\u3066\u3044\u305f\u304c\u3001\u539f\u56e0\u3082\u6cbb\u7642\u3082\u5f53\u6642\u306f\u4e0d\u660e\u3067\u3042\u3063\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1872\u5e74<br \/>\n24\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t\u9ad9\u6728\u517c\u5bdb\u3001\u6d77\u8ecd\u7701\u4e5d\u7b49\u51fa\u4ed5\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1875\u5e74<br \/>\n27\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t<div><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:0,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">\u9ad9\u6728\u517c\u5bdb\u30ed\u30f3\u30c9\u30f3\u306e\u30bb\u30f3\u30c8\u30fb\u30c8\u30fc\u30de\u30b9\u75c5\u9662\u533b\u5b66\u6821\u306b\u7559\u5b66\u3059\u308b\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__detail\">\n\t\t\t\t\t\t\t\t\t<br \/><\/span>\u8ecd\u8266\u300c\u7b51\u6ce2\u300d\u304c\u30db\u30ce\u30eb\u30eb\u3001\u30b5\u30f3\u30d5\u30e9\u30f3\u30b7\u30b9\u30b3\u3067\u306f\u554f\u984c\u306a\u304b\u3063\u305f\u304c\u3001\u5e30\u308a\u306b\u811a\u6c17\u304c\u983b\u767a\u3057\u305f\u3002<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1876\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t\u811a\u6c17\u306e\u7d30\u83cc\u8aac\u304c\u30c9\u30a4\u30c4\u306e\u30d9\u30eb\u30c4\u306b\u3088\u308a\u5531\u3048\u3089\u308c\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1878\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t\u8ecd\u8266\u300c\u7b51\u6ce2\u300d\u304c\u30b7\u30c9\u30cb\u30fc\u3067\u306f\u554f\u984c\u306a\u304b\u3063\u305f\u304c\u3001\u5e30\u308a\u306b\u811a\u6c17\u304c\u983b\u767a\u3057\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1880\u5e74 <br \/>\n32\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t11\u6708\u3000\u9ad9\u6728\u517c\u5bdb\u306f\u30ed\u30f3\u30c9\u30f3\u306e\u30bb\u30f3\u30c8\u30fb\u30c8\u30fc\u30de\u30b9\u75c5\u9662\u533b\u5b66\u6821\u304b\u3089\u5e30\u56fd\u3057\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1881\u5e74<br \/>\n33\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t5\u6708\u3000\u9ad9\u6728\u517c\u5bdb\u306f\u677e\u5c71\u68df\u5eb5\u3089\u3068\u9280\u5ea74 \u4e01\u76ee\u306b\u6210\u533b\u4f1a\u8b1b\u7fd2\u6240\uff08\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u524d\u8eab\uff09\u8a2d\u7acb\u3001\u6240\u9577\u306b\u306a\u308b\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1882\u5e74<br \/>\n34\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t6\u6708\u3000\u6d77\u8ecd\u8ecd\u533b\u5927\u76e3\u306b\u4efb\u305c\u3089\u308c\u308b\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__detail\">\n\t\t\t\t\t\t\t\t\t8\u6708\u3000\u6709\u5fd7\u5171\u7acb\u6771\u4eac\u75c5\u9662\uff08\u6211\u304c\u56fd\u521d\u306e\u79c1\u7acb\u65bd\u7642\u75c5\u9662\u3092\u8a2d\u7acb\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1883\u5e74 <br \/>\n35\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t<div><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:0,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">1882.12.19\u304b\u30891883.9.16\u306e\u822a\u6d77\u3000\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\u3001\u30c1\u30ea\u30fc\u3001\u30da\u30eb\u30fc\u3001\u30cf\u30ef\u30a4\u3000\u8ecd\u8266\u300c\u9f8d\u9a64\uff08\u308a\u3085\u3046\u3058\u3087\u3046\uff09\u300d\u3001\u4e57\u52d9\u54e1378\u4eba\u3001\u811a\u6c17169\u4eba\u3001\u6b7b\u4ea123\u4eba\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__detail\">\n\t\t\t\t\t\t\t\t\t<\/span><\/div><br \/>\n<div>\u9ad8\u6728\u517c\u5bdb\u306f\u98df\u7269\u4e2d\u306e\u30bf\u30f3\u30d1\u30af\u4e0d\u8db3\u304c\u811a\u6c17\u306e\u539f\u56e0\u8aac\u3092\u5531\u3048\u305f\u3002\u8ecd\u8266\u300c\u7b51\u6ce2\u300d\u306e\u6d77\u8ecd\u751f\u5f92\u8a13\u7df4\u822a\u6d77\u306e\u4e88\u5b9a\u3042\u308a\u3002\u9ad8\u6728\u306f\u98df\u4e8b\u3092\u91d1\u92ad\u3067\u306a\u304f\u73fe\u7269\u652f\u7d66\u3001\u9f8d\u9a64\uff08\u308a\u3085\u3046\u3058\u3087\u3046\uff09\u300d\u3068\u540c\u3058\u822a\u8def\u3067\u5b9f\u65bd\u3057\u305f\u3044\u3068\u4e3b\u5f35\u3057\u305f\u3002<\/div><br \/>\n<div>11\u6708\u3000\u6d77\u8ecd\u5c06\u5175\u306e\u811a\u6c17\u4e88\u9632\u7b56\u3068\u3057\u3066\u3001\u5175\u98df\u6539\u5584\u306e\u8981\u3092\u660e\u6cbb\u5929\u7687\u306b\u594f\u4e0a\u3059\u308b\u3002<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1884\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t<div><span class=\"text-edit\" data-cacoo-text-style=\"{&quot;index&quot;:0,&quot;font&quot;:&quot;Arial&quot;,&quot;size&quot;:15,&quot;color&quot;:&quot;000000&quot;,&quot;bold&quot;:false,&quot;italic&quot;:false,&quot;underline&quot;:false,&quot;strikeThrough&quot;:false,&quot;backgroundColor&quot;:&quot;&quot;}\">2\u6708\u3000\u5168\u6d77\u8ecd\u306e\u98df\u4e8b\u5927\u6539\u9769\u3002\u98df\u8cbb\u7d66\u4ed8\u3092\u73fe\u7269\u652f\u7d66\u306b\u6539\u9769\u3002\u5185\u5bb9\u3082\u5909\u66f4\u3002\u6d77\u8ecd\u306b\u304a\u3051\u308b\u811a\u6c17\u304c\u514b\u670d\u3055\u308c\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__detail\">\n\t\t\t\t\t\t\t\t\t<\/span><\/div><br \/>\n<div>1884.2.3\u20151884.11.16\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\u3001\u30c1\u30ea\u30fc\u3001\u30da\u30eb\u30fc\u3001\u30cf\u30ef\u30a4\u3000\u8ecd\u8266\u300c\u7b51\u6ce2\u300d\u3001\u4e57\u52d9\u54e1333\u4eba\u3001\u811a\u6c1715\u4eba\u3001\u6b7b\u4ea10\u4eba\u3002\u811a\u6c17\u306b\u304b\u304b\u3063\u305f15\u540d\u4e2d\u30018\u540d\u306f\u8089\u3092\u98df\u3079\u305a\u30014\u540d\u306f\u30b3\u30f3\u30c7\u30f3\u30b9\u30df\u30eb\u30af\u98f2\u307e\u305a\u3002\u98df\u4e8b\u304c\u811a\u6c17\u767a\u75c7\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u3002<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1885\u5e74 <br \/>\n37\u6b73\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t4\u6708\u3000\u6d77\u8ecd\u8ecd\u533b\u7dcf\u76e3\u306b\u4efb\u3058\u3089\u308c\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1906\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t\u30a8\u30a4\u30af\u30de\u30f3\uff08\u30aa\u30e9\u30f3\u30c0\uff09\u304c\u3001\u3053\u306e\u6804\u990a\u6b20\u9665\u8aac\u3092\u767a\u5c55\u3055\u305b\u3001\u3088\u3046\u3084\u304f\u30d3\u30bf\u30df\u30f3\u5b66\u8aac\u306b\u8fbf\u308a\u7740\u3044\u305f\u306e\u306f22\u5e74\u5f8c\u3067\u3042\u3063\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"timeline-history__item\">\n\t\t\t<div class=\"timeline-history__year\">\n\t\t\t\t\t\t\t\t\t<span class=\"timeline-history__year-label\">\n\t\t\t\t\t\t1929\u5e74\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"timeline-history__body\">\n\t\t\t\t<div class=\"timeline-history__row\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"timeline-history__date-line\">\n\t\t\t\t\t\t\t\t\t\u30a8\u30a4\u30af\u30de\u30f3\u306f\u6297\u811a\u6c17\u30d3\u30bf\u30df\u30f3\u3001\u3064\u307e\u308a\u30d3\u30bf\u30df\u30f3B1\u767a\u898b\u306e\u529f\u3092\u4ee5\u3066\u30ce\u30fc\u30d9\u30eb\u533b\u5b66\u751f\u7406\u5b66\u8cde\u3092\u53d7\u3051\u305f\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div><\/div>\n\n\n<p class=\"mb40\">\u53c2\u8003\u6587\u732e <br>\u30d3\u30bf\u30df\u30f3\u306e\u7236\u3000\u9ad8\u6728\u517c\u5bdb\u3002\u30d1\u30f3\u30d5\u30ec\u30c3\u30c8\u3002\u9ad8\u6728\u517c\u5bdb\u9855\u5f70\u4f1a\u3002\u5bae\u5d0e\u3002 <br>\u5409\u6751\u3000\u662d\u8457\u3002\u767d\u3044\u822a\u8de1(\u4e0a)(\u4e0b)\u3002\u8b1b\u8ac7\u793e\u3002\u6771\u4eac\u30021994.5.15\u3002 <br>\u5c71\u5d0e\u9707\u4e00\uff08\u3057\u3093\u3044\u3061\uff09\u8457\u3002\u30a6\u30a4\u30ea\u30a2\u30e0\u30fb\u30a6\u30a4\u30eb\u30b9\u4f1d\u3002\u66f8\u7c4d\u5de5\u623f\u65e9\u5c71\u3002\u6771\u4eac\u30022019.1.25<\/p>\n\n\n\n<p class=\"anchor\" id=\"award-akiba\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-2g5zv6 wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u5f8c\u85e4\u559c\u4ee3\u5b50\u30fb\u30dd\u30fc\u30eb\u30d6\u30eb\u30c0\u30ea\u79d1\u5b66\u8cde\u53d7\u8cde\uff08\u79cb\u8449\u76f4\u5fd7\uff09<\/h2><\/div>\n\n\n<p>\u6148\u6075\u5927\u5b66\u9644\u5c5e\u67cf\u75c5\u9662\u306e\u79cb\u8449\u76f4\u5fd7\u9662\u9577\u3068\u9644\u5c5e\u75c5\u9662\u306e\u6d66\u5cf6\u5145\u4f73\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u3001\u304c\u3093\u306e\u518d\u767a\u30fb\u6b7b\u4ea1\u4e88\u9632\u306b\u6709\u52b9\u306a\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u4e16\u754c\u6709\u6570\u96d1\u8a8c\u3067\u3042\u308b\u3001\u300cClinical Cancer Research\uff08\u81e8\u5e8a\u764c\u7814\u7a76\u8a8c\uff09\u300d\u306b\u8ad6\u6587\u304c\u63b2\u8f09\u3055\u308c\u305f\u3002 <br><\/p>\n\n\n\n<p class=\"mb40\">\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u3000\u5f8c\u85e4\u559c\u4ee3\u5b50\u30fb\u30dd\u30fc\u30eb\u30d6\u30eb\u30c0\u30ea\u764c\u57fa\u91d1\u5354\u4f1a\u306f\u65e5\u672c\u4eba\u306e\u611b\u59bb\u3092\u80ba\u304c\u3093\u3067\u4ea1\u304f\u3057\u305f\u30d5\u30e9\u30f3\u30b9\u4eba Paul Bourdarie \u6c0f\u306e\u6d44\u8ca1\uff15\u5104\u5186\u3092\u57fa\u91d1\u3068\u3057\u305f\u5354\u4f1a\u3067\u3042\u308b\u3002\u3053\u3053\u304c\u4e3b\u50ac\u3059\u308b\u300c\u764c\u64b2\u6ec5\u306b\u5bc4\u4e0e\u3059\u308b\u57fa\u790e\u533b\u5b66\u53ca\u3073\u81e8\u5e8a\u533b\u5b66\u306b\u95a2\u3059\u308b\u512a\u79c0\u306a\u5b66\u8853\u8ad6\u6587\u3092\u8457\u3057\u305f\u65e5\u672c\u4eba\u533b\u5b66\u8005\u3092\u9855\u5f70\u3059\u308b\u4e8b\u696d\u300d\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u5ea62018\u5e74\u5ea6\u300c\u7b2c7\u56de \u5f8c\u85e4\u559c\u4ee3\u5b50\u30fb\u30dd\u30fc\u30eb\u30d6\u30eb\u30c0\u30ea\u79d1\u5b66\u8cde\u300d\u3092\u5f53\u9662(\u6148\u6075\u533b\u5927\u67cf\u75c5\u9662)\u306e\u79cb\u8449\u76f4\u5fd7\u9662\u9577\u304c\u53d7\u8cde\u3057\u305f\u3002 <br>\u672c\u79d1\u5b66\u8cde\u306f\u30d5\u30e9\u30f3\u30b9\u4eba\u79d1\u5b66\u8005\u3092\u542b\u3080\uff17\u540d\u306e\u8aee\u554f\u59d4\u54e1\u4f1a\u3067\u300123\u7de8\u306e\u8ad6\u6587\u306e\u4e2d\u304b\u3089\u79cb\u8449\u9662\u9577\u304c\u7b2c\u4e00\u8457\u8005\u306e\u539f\u8457\u8ad6\u6587\u304c\u6700\u3082\u9ad8\u3044\u8a55\u4fa1\u3092\u53d7\u3051\u3001\u79d1\u5b66\u8cde\u306b\u9078\u3070\u308c\u305f\u3002 <br>\u6388\u8cde\u5f0f\u306f\u3001\u4ee4\u548c\u5143\u5e746\u67084\u65e5\u3001\u6e2f\u533a\u5357\u9ebb\u5e03\u306e\u5e83\u5927\u306a\u7dd1\u306e\u6577\u5730\u306b\u5728\u308b\u30d5\u30e9\u30f3\u30b9\u5927\u4f7f\u516c\u90b8\u3067\u99d0\u65e5\u30d5\u30e9\u30f3\u30b9\u5927\u4f7f\u30ed\u30fc\u30e9\u30f3\u30fb\u30d4\u30c3\u30af\u6c0f\u81e8\u5e2d\u306e\u5143\u3067\u76db\u5927\u306b\u958b\u50ac\u3055\u308c\u305f\u3002 <br>\u79cb\u8449\u9662\u9577\u3088\u308a\u3001\u300c\u80ba\u304c\u3093\u306e\u30aa\u30d7\u30b8\u30fc\u30dc\u6cbb\u7642\u306f\u5e74\u9593\u7d041,000\u4e07\u5186\u306e\u6cbb\u7642\u8cbb\u304c\u304b\u304b\u308b\u304c\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u5e74\u9593\u7d04\uff11\u4e07\u5186\u7a0b\u5ea6\u3001\u65e5\u5149\u6d74\u3067\u3042\u308c\u3070\u7121\u6599\u3067\u88dc\u7d66\u3067\u304d\u308b\u3053\u3068\u3001\u6148\u6075\u5927\u5b66\u5b66\u7956\u9ad8\u6728\u517c\u5bdb\u5148\u751f\u306f\u30d3\u30bf\u30df\u30f3\u304c\u767a\u898b\u3055\u308c\u308b\u524d\u306b\u811a\u6c17\u3092\u98df\u4e8b\u3067\u514b\u670d\u3057\u591a\u304f\u306e\u547d\u3092\u6551\u3063\u305f\u3053\u3068\u3001\u9855\u5f70\u91d1350\u4e07\u5186\u3092\u6d3b\u7528\u3057\u7814\u7a76\u3092\u62e1\u5927\u3057\u3066\u3044\u304d\u305f\u3044\u300d\u3068\u306e\u6328\u62f6\u304c\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-lung-cancer\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-19fPlw wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u80ba\u304c\u3093\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/h2><\/div>\n\n\n<p class=\"mb40\">\u80ba\u304c\u3093\u306e\u6cbb\u7642\u306f\u624b\u8853\u3001\u653e\u5c04\u7dda\u3001\u6297\u304c\u3093\u5264\u3001\u514d\u75ab\u7642\u6cd5\u306e4\u3064\u306e\u67f1\u3067\u6210\u308a\u7acb\u3063\u3066\u304a\u308a\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308b\u6cbb\u7642\u306f\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u9867\u307f\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3\uff24\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u3044\u3068\u767a\u304c\u3093\u3084\u518d\u767a\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u306e\u5831\u544a\u306f\u3042\u3063\u305f\u3002\u672c\u8ad6\u6587\u306f\u547c\u5438\u5668\u5916\u79d1\u3068\u5206\u5b50\u75ab\u5b66\u7814\u7a76\u90e8\u306e8\u5e74\u306e\u7814\u7a76\u3067\u3001\u80ba\u304c\u3093\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u305f\u3002 <br>\u7d50\u679c\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3057\u3066\u3044\u305f\u65e9\u671f\u306e\u80ba\u817a\u304c\u3093\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u5185\u670d\u3059\u308b\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u5185\u670d\u3088\u308a\u6210\u7e3e\u304c\u3088\u304b\u3063\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u753b\u671f\u7684\u3067\u3042\u308b\u3002\u904e\u5270\u306b\u6442\u53d6\u3057\u306a\u3051\u308c\u3070\u30d3\u30bf\u30df\u30f3\uff24\u670d\u7528\u306b\u306f\u526f\u4f5c\u7528\u304c\u307b\u3068\u3093\u3069\u306a\u3044\u3002\u518d\u767a\u4e88\u9632\u3060\u3051\u3067\u306a\u304f\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3068\u306a\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3002\u9ad8\u9a30\u3059\u308b\u304c\u3093\u6cbb\u7642\u3068\u7570\u306a\u308a\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u5b89\u4fa1\u3067\u3042\u308a\u3001\u65e5\u5149\u6d74\u3067\u88dc\u7d66\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3042\u308b\u3002 <br>\u591a\u304f\u306e\u65e5\u672c\u4eba\u3084\u5404\u56fd\u3067\u30d3\u30bf\u30df\u30f3D\u306f\u4e0d\u8db3\u3084\u6b20\u4e4f\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u306f\u65e5\u5149\u306b\u5f53\u305f\u3089\u306a\u3044\u3053\u3068\u3084\u3001\u9ad8\u9f62\u8005\u3067\u306f\u76ae\u819a\u3067\u306e\u5408\u6210\u80fd\u529b\u306e\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u3002\u901a\u5e38\u306e\u98df\u4e8b\u3067\u4e0d\u8db3\u3057\u3066\u3044\u305f\u3089\u3001\u80ba\u304c\u3093\u6cbb\u7642\u306e\u89b3\u70b9\u3067\u3060\u3051\u3067\u306a\u304f\u3001\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u3082\u88dc\u7d66\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"anchor\" id=\"award-paper\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z1f4xRk wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u53d7\u8cde\u8ad6\u6587\u7d39\u4ecb<\/h2><\/div>\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306e\u751f\u5b58\uff1a\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u300d \u8457\u8005\uff1a\u79cb\u8449\u76f4\u5fd7\u3001\u6d66\u5cf6\u5145\u4f73\u3089\uff0e\u96d1\u8a8c\uff1aClin Cancer Res. 2018 Sep 1;24(17):4089-4097.<\/p>\n\n\n<div class=\"lazyblock-h3-01-ZgQP0H wp-block-lazyblock-h3-01\"><h3 class=\"h3-01\">\u8981\u7d04<\/h3><\/div>\n\n\n<p class=\"mb40\"><strong>\u76ee\u7684<\/strong>\uff1a\u9ad8\u8840\u6e0525(OH)D\u30ec\u30d9\u30eb\u306f\u3001\u65e9\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u3067\u3001\u826f\u3044\u4e88\u5f8c\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u305f\u3002 <br><strong>\u60a3\u8005\u3068\u65b9\u6cd5<\/strong>\uff1a\u8853\u5f8c1\u5e74\u306e\u9593\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u5185\u670d\uff0830\u338d\u3001\u307e\u305f\u306f1,200IU\/\u65e5\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u5185\u670d\u3092\u6bd4\u8f03\u3057\u305f\u7121\u4f5c\u70ba\uff08\u30e9\u30f3\u30c0\u30e0\u5316\uff09\u4e8c\u91cd\u76f2\u691c\u7814\u7a76\u3092\u884c\u3063\u305f\u3002\u4e00\u6b21\u304a\u3088\u3073\u4e8c\u6b21\u8a55\u4fa1\u76ee\u6a19\u306f\u3001\u7121\u518d\u767a\u751f\u5b58\uff08RFS\uff09\u3068\u751f\u5b58\u7387\uff08OS\uff09\u3067\u3042\u308b\u3002\u4e8b\u524d\u7279\u5b9a\u3057\u305f\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306f\u3001\u30b9\u30c6\u30fc\u30b8\uff08\u65e9\u671f\u3000\u5bfe\u3000\u9032\u884c\uff09\u3001\u75c5\u7406\u7d44\u7e54\uff08\u817a\u304c\u3093\u3000\u5bfe\u3000\u4ed6\uff09\u306825(OH)D\u30ec\u30d9\u30eb\uff08\uff1c20ng\/mL\u3000\u5bfe\u3000\u226520ng\/mL\uff09\u3067\u5c64\u5225\u5316\u3057\u3066\u5b9f\u884c\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u3068\u30d3\u30bf\u30df\u30f3D-\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08DBP\uff09\u306e\u907a\u4f1d\u5b50\u591a\u578b\u578b\u3068\u4e88\u5f8c\u306e\u95a2\u4fc2\u3082\u8abf\u3079\u305f\u3002<br><strong>\u7d50\u679c<\/strong>\uff1a\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\uff08n = 155\uff09\u60a3\u8005\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u7fa4\uff08n = 77\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n = 78\uff09\u306b\u7121\u4f5c\u70ba\u5272\u4ed8\u3051\u3057\u3066\u30013.3\u5e74\u306e\u4e2d\u592e\u5024\u306e\u7d4c\u904e\u3092\u898b\u305f\u3002\u305d\u308c\u305e\u308c\u3001\u518d\u767a\u3068\u6b7b\u4ea1\u306f40\u4eba\uff0828%\uff09\u306824\u4eba\uff0817%\uff09\u306b\u8d77\u304d\u305f\u3002\u5168\u4f53\u3067\u3001\u7121\u518d\u767a\u751f\u5b58\uff08RFS\uff09\u304b\u751f\u5b58\u7387\uff08OS\uff09\u306b\u95a2\u3059\u308b\u6709\u610f\u5dee\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u30d3\u30bf\u30df\u30f3D\u7fa4\u3092\u6bd4\u8f03\u3057\u3066\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u5206\u6790\u309225(OH)D\uff1c20ng\/mL\u3067\u521d\u671f\u817a\u304c\u3093\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u5236\u9650\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3001\u304b\u306a\u308a\u826f\u30445\u5e74\u306e\u7121\u518d\u767a\u751f\u5b58\uff08RFS\uff09\uff0886%\u5bfe50%\uff08P = 0.04\uff09\uff09\u3068\u751f\u5b58\u7387\uff08OS\uff09\uff0891%\u5bfe48%\uff08P = 0.02\uff09\uff09\u3092\u793a\u3057\u305f\u3002\u8abf\u3079\u3089\u308c\u305f\u907a\u4f1d\u5b50\u591a\u578b\u3001DBP1\u3000TT\u3068CDX2 \u3000AA\/AG\u907a\u4f1d\u5b50\u578b\u306f\u3001\u591a\u5909\u91cf\u89e3\u6790\u3067\u3055\u3048\u3001\u3088\u308a\u826f\u3044\u4e88\u5f8c\u306e\u6307\u6a19\u3067\u3042\u3063\u305f\u3002<br><strong>\u7d50\u8ad6<\/strong>\uff1a\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u4f4e25(OH)D\u30ec\u30d9\u30eb\uff1c20ng\/mL\u3067\u3001\u521d\u671f\u80ba\u817a\u304c\u3093\u60a3\u8005\u306e\u751f\u5b58\u3092\u6539\u5584\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-cancer-papers\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-rsVF0 wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u6700\u8fd1\u306e\u304c\u3093\u3068\u30d3\u30bf\u30df\u30f3D\u8ad6\u6587<\/h2><\/div>\n\n\n<p>\u3053\u3053\u6570\u5e74\u3001\u304c\u3093\u3068\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u3059\u308b\u82f1\u6587\u8ad6\u6587\u306fPubMed\u306b\u3088\u308b\u3068\u6bce\u5e74500\u672c\u4ee5\u4e0a\u3042\u308b\u3002<\/p>\n\n\n\n<p>Araz\u3089\uff082019\u5e74\uff09\u306f\u3001\u30c8\u30eb\u30b3\u3067\u80ba\u304c\u3093\u3068\u8a3a\u65ad\u3055\u308c\u305f247\u4eba\u306e\u60a3\u8005\u306e\u5206\u6790\u3092\u3057\u305f\u3002153\u4eba\u306e\u60a3\u8005\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306f15ng\/mL\u4ee5\u4e0b\uff08\u6b20\u4e4f\uff09\u3067\u3042\u3063\u305f\u300265\u4eba\u306e\u60a3\u8005\u306f15-30ng\/mL\uff08\u6b20\u4e4f\u307e\u305f\u306f\u4e0d\u5145\u5206\uff09\u306e\u30ec\u30d9\u30eb\u3067\u300129\u4eba\u306e\u60a3\u8005\u306f\u30d3\u30bf\u30df\u30f3D\u304c30ng\/mL\u3092\u8d85\u3048\u305f\u300232\u4eba\u306e\u30d3\u30bf\u30df\u30f3D\u88dc\u5145\u304c300.000IU\u4ee5\u4e0a\u3067\u3001215\u4eba\u306f300.000IU\u4ee5\u4e0b\u3067\u3042\u3063\u305f\u3002\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u8a3a\u65ad\u306e\u6642\u70b9\u306e\u30d3\u30bf\u30df\u30f3D\u3068\u88dc\u5145\u91cf\u306f\u3001\u5316\u5b66\u7642\u6cd5\u6cbb\u7642\u52b9\u679c\u3092\u5909\u3048\u306a\u304b\u3063\u305f\u3002 <br>Araz M, et al. Does Vitamin D Replacement Alter the Chemotherapy Outcome in Lung Cancer. EJMO 2019;3(2):112-115.<\/p>\n\n\n\n<p>Degirmencioglu\u3089\uff082019\u5e74\uff09\u306f462\u4eba\u306e\u80ba\u304c\u3093\u60a3\u8005\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3092\u5831\u544a\u3057\u305f\u3002\u80ba\u304c\u3093\u60a3\u8005\u3068\u5bfe\u7167\u8005\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u8840\u6e0525\uff08OH\uff09D\u6fc3\u5ea6\uff08\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\uff09\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3001LDH\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u6fc3\u5ea6\u306f\u6709\u610f\u306b\u60a3\u8005\u7fa4\u3067\u4f4e\u3044\u3002\u8840\u6e0525\uff08OH\uff09D\u6fc3\u5ea6\u306f\u3001\u817a\u304c\u3093\u3068\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u817a\u304c\u3093\u3067\u6709\u610f\u306b\u4f4e\u3044\u3002\u8840\u6e0525\uff08OH\uff09D\u6fc3\u5ea6\u306f\u3001\u75c5\u671f\u304c\u9032\u884c\u3059\u308b\u3068\u3001\u6709\u610f\u306b\u4f4e\u3044\u3002LDH\u6fc3\u5ea6\u306f\u3001\u75c5\u671f\u304c\u9032\u884c\u3059\u308b\u3068\u3001\u6709\u610f\u306b\u9ad8\u3044\u3002 <br>Degirmencioglu S, et al. Clinical Significance of Serum 25-Hydroxyvitamin D Levels in Non-Small Cell Lung Cancer. EJMO 2019;3(2):139-143<\/p>\n\n\n\n<p>Wu\u3089\uff082019\u5e74\uff09\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u75ab\u5b66\u7684\u7814\u7a76\u3068\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u73fe\u5728\u306e\u77e5\u8b58\u3092\u6982\u8aac\u3057\u305f\u3002\u7279\u306b\u3001\u304c\u3093\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u3092\u3088\u308a\u826f\u304f\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001\u304c\u3093\u7d30\u80de\u3001\u304c\u3093\u5e79\u7d30\u80de\u3068\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u3067\u3042\u308b\u57fa\u8cea\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u6297\u304c\u3093\u4f5c\u7528\u3092\u8981\u7d04\u3057\u8b70\u8ad6\u3057\u305f\u3002\u524d\u7acb\u817a\u304c\u3093\u3001\u4e73\u304c\u3093\u3001\u5927\u8178\u304c\u3093\u3001\u4e0a\u90e8\u6d88\u5316\u7ba1\u304c\u3093\u3001\u305d\u306e\u4ed6\u306e\u304c\u3093\u75ab\u5b66\u7684\u7814\u7a76\u306b\u3064\u3044\u3066\u8ad6\u3058\u305f\u3002\u304c\u3093\u6cbb\u7642\u306e\u305f\u3081\u306e\u30d3\u30bf\u30df\u30f3D\u3068\u305d\u306e\u985e\u4f3c\u5316\u5408\u7269\u306b\u3088\u308b14\u306e\u81e8\u5e8a\u7814\u7a76\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u3053\u3053\u306b\u30d3\u30bf\u30df\u30f3D\u3092\u65b0\u3057\u3044\u305d\u3057\u3066\u7d4c\u6e08\u7684\u306a\u6297\u304c\u3093\u5264\u3067\u3042\u308b\u3068\u3057\u3066\u518d\u63d0\u6848\u3057\u305f\u3002 <br>Wu X1, et al. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment. Acta Pharm Sin B. 2019;9(2):203-219.<\/p>\n\n\n\n<p>Cusuto\u3089\uff082019\u5e74\uff09\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306f\u3001\u304c\u3093\u60a3\u8005\u3067\u3057\u3070\u3057\u3070\u89b3\u5bdf\u3055\u308c\u308b\u3068\u8ff0\u3079\u3066\u3044\u308b\u3002\u5e7e\u3064\u304b\u306e\u7814\u7a76\u3067\u3001\u30d3\u30bf\u30df\u30f3D3\uff0825-VD\uff09\u8840\u6e05\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\u3053\u3068\u3068\u80ba\u304c\u3093\u306e\u4e88\u5f8c\u304c\u60aa\u3044\u3053\u3068\u304c\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u5831\u544a\u3057\u305f\u3002 <br>\uff14\uff15\u4eba\u306e\u60a3\u8005\u3067\u7814\u7a76\u3092\u884c\u3063\u305f\u3002\u80ba\u764c\u514d\u75ab\u7642\u6cd5\u306e\u30cb\u30dc\u30eb\u30de\u30d6\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\uff1aNivolumab\uff09\u8840\u6db2\u4e2d\u6fc3\u5ea6\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u4ee3\u8b1d\u7d4c\u8def\u95a2\u9023\u306e\u907a\u4f1d\u5b50\uff08\u4e00\u5869\u57fa\u907a\u4f1d\u5b50\u591a\u578b\uff1asingle nucleotide polymorphisms\uff1aSNP\uff09\u306b\u5f71\u97ff\u3092\u53d7\u3051\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceaVDBP AC\/CC\u907a\u4f1d\u5b50\u578b\u3068\u30cb\u30dc\u30eb\u30de\u30d6\u6cbb\u764215\u65e5\u76ee\u306e\u57fa\u672c\u7684\u306a\u30d3\u30bf\u30df\u30f3\u6fc3\u5ea6\u4f4e\u4e0b\uff0825-VD\uff1c10ng\/mL\uff09\u306f\u3001\u816b\u760d\u9032\u884c\u3068\u95a2\u4fc2\u3059\u308b\u30cb\u30dc\u30eb\u30de\u30d6\u6fc3\u5ea6\u4f4e\u4e0b\uff08\uff1c18.7ug\/mL\uff09\u3092\u4e88\u6e2c\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u6cbb\u7642\u306e\u73fe\u5b9f\u3067\u30cb\u30dc\u30eb\u30de\u30d6\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\uff1aNivolumab\uff09\u6fc3\u5ea6\u3092\u30d3\u30bf\u30df\u30f3D\u30de\u30fc\u30ab\u30fc\u304c\u4e88\u6e2c\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u6700\u521d\u306e\u7814\u7a76\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30d3\u30bf\u30df\u30f3D3\uff0825-VD\uff09\u306f\u30cb\u30dc\u30eb\u30de\u30d6\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\uff1aNivolumab\uff09\u6fc3\u5ea6\u306b\u5f71\u97ff\u3057\u305f\u3001\u30d3\u30bf\u30df\u30f3D3\uff08\u6d3b\u6027\u578b\uff1a1\u300125-VD\uff09\u3067\u306f\u306a\u3044\u3002\u3053\u3053\u3067\u306f\u3001\u30cb\u30dc\u30eb\u30de\u30d6\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\uff1aNivolumab\uff09\u3068VD\u6fc3\u5ea6\u3092\u8a55\u4fa1\u3057\u305f\u3060\u3051\u3067\u3042\u308b\u3001\u514d\u75ab\u7d30\u80de\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u3067\u306f\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306f\u514d\u75ab\u7cfb\u306b\u95a2\u4e0e\u3057\u518d\u767a\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3057\u3001\u305d\u308c\u306f\u6cbb\u7642\u306b\u76f4\u63a5\u95a2\u9023\u304c\u3042\u308b\u3002 <br>\u4eca\u56de\u306e\u5206\u6790\u306f\u4e88\u5099\u7684\u3067\u3001\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u304c\u3042\u308b\u3053\u3068\u306f\u91cd\u8981\u3067\u3042\u308b\u300245\u4eba\u306e\u60a3\u8005\u3060\u3051\u3067\u5206\u6790\u3055\u308c\u3001\u305d\u3057\u3066\u3001\u907a\u4f1d\u5b50VDBP SNP\u306f\u5883\u754c\u7dda\u4e0a\u306e\u5f71\u97ff\u3060\u3063\u305f\u3002 <br>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u514d\u75ab\u7cfb\u3092\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u305d\u306e\u5408\u6210\u306f\u3001\u76ae\u819a\u7d44\u7e54\u306e\u7d2b\u5916\u7dda\u5149\u306e\u4f5c\u7528\u304b\u3089\u59cb\u307e\u308b\u3002\u30d3\u30bf\u30df\u30f3D3\uff08\u30b3\u30ec\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff1aCholecalciferol\uff09\u306f\u3001\u30c1\u30c8\u30af\u30ed\u30e0P-450\uff08CYP\u300127A1\u30012R1\uff09\u3092\u4ecb\u3057\u3066\u3001\u809d\u81d3\u306725-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D3\uff08\u30ab\u30eb\u30b7\u30d5\u30a7\u30c7\u30ed\u30fc\u30eb\uff1acalcifediol\uff1a25-VD\uff09\u306b\u6c34\u9178\u5316\u3055\u308c\u308b\u3002\u814e\u81d3\u306b\u304a\u3044\u3066\u30011\u03b1\u300125-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D3\uff08\u30ab\u30eb\u30b7\u30c8\u30ea\u30aa\u30fc\u30eb\uff1acalcitriol \uff1a1\u300125-VD\u3001\u6d3b\u6027\u578b\uff09\u306f\u3001CYP27B1\u3092\u901a\u3057\u3066\u5408\u6210\u3055\u308c\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08VDBP\uff1avitamin D binding protein\uff09\u3092\u901a\u3057\u3066\u3001\u8840\u6d41\u3067\u8f38\u9001\u3055\u308c\u308b\u300225-VD\u306ecalcitroic\u9178\uff0824\u300125-VD\uff09\u3078\u306e\u4e0d\u6d3b\u5316\u306f\u3001CYP24A1\u306b\u3088\u3063\u3066\u7d9a\u3051\u3089\u308c\u308b\u3002 <br>\u6211\u3005\u306e\u7814\u7a76\u306f\u81e8\u5e8a\u533b\u306b\u3001\u6cbb\u7642\u3092\u59cb\u3081\u308b\u524d\u306b\u300125-VD\u30ec\u30d9\u30eb\u3068VDBP rs7041\u907a\u4f1d\u5b50\u578b\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u300115\u65e5\u306e\u30cb\u30dc\u30eb\u30de\u30d6\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\uff1aNivolumab\uff09\u6fc3\u5ea6\u3092\u5b9a\u91cf\u5316\u3057\u3001\u6295\u85ac\u91cf\u306e\u52a0\u6e1b\u3084VD\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u8ffd\u52a0\u3092\u8003\u3048\u308b\u816b\u760d\u9032\u884c\u306e\u5371\u967a\u6027\u3092\u6e1b\u3089\u3059\u3053\u3068\u3092\u52e7\u3081\u308b\u3002\u305d\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u5206\u6790\u306b\u306f\u4e88\u5099\u7684\u3067\u3001\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u304c\u3042\u308b\u3053\u3068\u306f\u91cd\u8981\u3067\u3042\u308b\u3002 <br>Cusato J1, et al. Influence of Vitamin D in Advanced Non-Small Cell Lung Cancer Patients Treated with Nivolumab. Cancers (Basel). 2019;11(1). 125<\/p>\n\n\n\n<p>Ng\u3089\uff082019\u5e74\uff09\u306f139\u4eba\u306emFOLFOX6+\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3063\u305f\u8ee2\u79fb\u6027\u9032\u884c\u5927\u8178\u304c\u3093\u60a3\u8005\u306b\u5bfe\u3057\u3001\u9ad8\u5bb9\u91cf\u30d3\u30bf\u30df\u30f3D\u6295\u4e0e\u3068\u6a19\u6e96\u6295\u4e0e\u3001\uff12\u91cd\u76f2\u691c\u3001\uff12\u76f8\u8a66\u9a13\u3001\u304f\u3058\u5f15\u304d\u7814\u7a76\u3092\u884c\u3063\u305f\u300225\u30cf\u30a4\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u3001\u7814\u7a76\u3092\u59cb\u3081\u305f\u6642\u70b9\u3067\u5341\u5206\u306a\u6fc3\u5ea6\u306b\u9054\u3057\u3066\u3044\u305f\u306e\u306f\u308f\u305a\u304b9\uff05\u3067\u3042\u3063\u305f\u3002\u5168\u4f53\u751f\u5b58\u7387\u3067\u306f\u6709\u610f\u306a\u5dee\u306f\u306a\u304b\u3063\u305f\u304c\u3001\u7121\u518d\u767a\u751f\u5b58\u7387\u306f\u9ad8\u5bb9\u91cf\u30d3\u30bf\u30df\u30f3D\u7fa4\u304c\u6709\u610f\u306b\u826f\u597d\u3067\u3042\u3063\u305f\u3002 <br>Ng K, et al. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019;321(14):1370-1379<\/p>\n\n\n\n<p>Li\u3089\uff082019\u5e74\uff09\u306f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08\u8907\u6570\u7814\u7a76\u7d71\u5408\u89e3\u6790\uff09\u3092\u884c\u3044\u3001\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u306b\u304a\u3051\u308bBsm1\u3001Apal\u3001Taq1\u3001Cdx-2\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u3001\u80ba\u304c\u3093\u7f79\u60a3\u306b\u95a2\u4fc2\u3059\u308b\u304b\u3092\u8abf\u3079\u305f\u30026\u3064\u306e\u8ad6\u6587\u3092\u4f7f\u7528\u3057\u305f\u3002Bsm1\u3001Taq1\u3001Cdx-2\u306e\u907a\u4f1d\u5b50\u591a\u578b\u306f\u80ba\u304c\u3093\u7f79\u75c5\u3057\u3084\u3059\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002 <br>Li M, et al. 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J Cancer. 2019 Jun 9;10(16):3639-3649.<\/p>\n\n\n\n<p>Scragg\u3089\uff082019\u5e74\uff09\u306e\u30d3\u30bf\u30df\u30f3D\u8a55\u4fa1\uff08ViDA\uff09\u8a66\u9a13\u306f\u3001\u6bce\u6708\u306e\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306e\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u308b\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\u306e\u30aa\u30fc\u30af\u30e9\u30f3\u30c9\u3067\u300150\u6b73\u304b\u308984\u6b73\u306e5,110\u4eba\u306e\u6210\u4eba\u306e\u9593\u3067\u884c\u308f\u308c\u3001\u4ecb\u5165\u306f\u30d3\u30bf\u30df\u30f3D 3\uff082.5 mg\uff1d100,000 IU\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3067\u3001\u6bce\u6708\u53c2\u52a0\u8005\u306e\u5bb6\u306b\u90f5\u9001\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u8ee2\u5012\u3001\u975e\u810a\u690e\u9aa8\u6298\u3001\u3059\u3079\u3066\u306e\u764c\u306e\u767a\u751f\u7387\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306e\u6709\u76ca\u306a\u52b9\u679c\u3092\u793a\u3055\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306b\u3088\u308b\u4ee5\u4e0b\u306e\u6709\u76ca\u306a\u52b9\u679c\u304c\u898b\u3089\u308c\u305f\u3002\u9577\u671f\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\uff08\u9ad8\u8102\u8840\u75c7\uff09\u3092\u53d7\u3051\u3066\u3044\u308b\u53c2\u52a0\u8005\u306b\u30b9\u30bf\u30c1\u30f3\u670d\u7528\u306e\u6301\u7d9a\u3002\u307e\u305f\u300125-\u30cf\u30a4\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3 D\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\u53c2\u52a0\u8005\u306e\u9aa8\u5bc6\u5ea6\u3001\u52d5\u8108\u6a5f\u80fd\u3001\u55ab\u7159\u8005\u306e\u80ba\u6a5f\u80fd\uff08\u7279\u306b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\uff09\u306b\u3082\u898b\u3089\u308c\u305f\u3002\u67081\u56de\u306e\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306f\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u3092\u4e88\u9632\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u304c\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306e\u4eba\u3005\u306e\u4e2d\u9593\u8ee2\u5e30\u306b\u306f\u6709\u76ca\u304b\u3082\u3057\u308c\u306a\u3044\u3002 <br>Scragg RKR. Overview of results from the Vitamin D Assessment (ViDA) study. J Endocrinol Invest. 2019 May 23. [Epub ahead of print]<\/p>\n\n\n\n<p>Zhu\u3089\uff082019\u5e74\uff09\u306f\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u8840\u6e0525\uff08OH\uff09D\uff08\u30d3\u30bf\u30df\u30f3 D\uff09\u306e\u76ae\u819a\u304c\u3093\u4ee5\u5916\u306e\u304c\u3093\u306e\u767a\u751f\u7387\u3068\u6b7b\u4ea1\u7387\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u305f\u3002\u8840\u6e0525\uff08OH\uff09D\u306f\u300125\uff5e84\u6b73\u306e1994\u20151995\u5e74\u306b3,818\u4eba\u306e\u53c2\u52a0\u8005\uff082,166\u4eba\u306e\u5973\u6027\uff09\u3067\u6e2c\u5b9a\u3057\u305f\u3002\u5168\u4f53\u7684\u306a\u304c\u3093\u306e\u5371\u967a\u3067\u306a\u304f\u3001\u7d50\u8178\u76f4\u8178\u304c\u3093\u304a\u3088\u3073\u4e73\u304c\u3093\u306e\u5897\u52a0\u3068\u95a2\u4fc2\u3057\u3066\u3044\u305f\u3002 <br>Zhu K, et al. Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: a 20-year cohort study. Nutr Res. 2019;67:100-107.<\/p>\n\n\n\n<p>Cehreli\u3089\uff082019\u5e74\uff09\u306f\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u3068\u8a3a\u65ad\u3057\u305f25\u4eba\u306e\u60a3\u8005\u3092\u524d\u5411\u304d\u7814\u7a76\u306b\u767b\u9332\u3057\u305f\u3002\u6cbb\u7642\u524d\u306e\u8840\u6e05\u30a2\u30eb\u30d6\u30df\u30f3\u3001\u30d7\u30ec\u30a2\u30eb\u30d6\u30df\u30f3\u3001\u30d3\u30bf\u30df\u30f3D\u3001\u4e9c\u925b\uff08Zn\uff09\u3001C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08CRP\uff09\u3001IL-6\u3001IL-1\u03b2\u3001TNF-\u03b1\u3001\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30d1\u30fc\u30bc\uff08LPL\uff09\u3001\u304a\u3088\u3073\u30b0\u30e9\u30b9\u30b4\u30fc\u4e88\u5f8c\u30b9\u30b3\u30a2 \uff08GPS\uff09\u3092\u6e2c\u5b9a\u3057\u305f\u3002\u6804\u990a\u4e0d\u826f\u304a\u3088\u3073\u60aa\u6db2\u8cea\u306f\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306e\u816b\u760d\u5b66\u7684\u8ee2\u5e30\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3002\u3053\u308c\u3089\u306e\u6804\u990a\/\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u306f\u3001\u88dc\u52a9\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u30ea\u30b9\u30af\u304a\u3088\u3073\u751f\u5b58\u7387\u306e\u4f4e\u4e0b\u306e\u8a55\u4fa1\u306b\u6709\u7528\u3067\u3042\u308a\u5f97\u308b\u3002 <br>Cehreli R, et al. 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Biomed Res Int. 2019;2019:1648072.<\/p>\n\n\n\n<p>Alsharairi\uff082019\u5e74\uff09\u306f\u6210\u4eba\u306e\u55ab\u7159\u8005\u3068\u975e\u55ab\u7159\u8005\u306b\u304a\u3051\u308b\u6804\u990a\u88dc\u52a9\u98df\u54c1\u3068\u80ba\u304c\u3093\u30ea\u30b9\u30af\u306e\u524d\u5411\u304d\u7814\u7a76\u3068\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u3092\u884c\u3044\u3001\u4e00\u8cab\u6027\u306e\u306a\u3044\u7d50\u679c\u3092\u5f97\u305f\u3002\u3044\u304f\u3064\u304b\u306e\u524d\u5411\u304d\u7814\u7a76\u3067\u306f\u3001\u30ec\u30c1\u30ce\u30fc\u30eb\u3001\u03b2-\u30ab\u30ed\u30c1\u30f3\u3001\u30d3\u30bf\u30df\u30f3B\u3001\u30d3\u30bf\u30df\u30f3E\u306a\u3069\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u9577\u671f\u9593\u5927\u91cf\u306b\u4f7f\u7528\u3059\u308b\u3068\u3001\u73fe\u5728\u304a\u3088\u3073\u4ee5\u524d\u306e\u55ab\u7159\u8005\u306e\u80ba\u304c\u3093\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 RCT\u304b\u3089\u306e\u9650\u3089\u308c\u305f\u8a3c\u62e0\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u88dc\u7d66\u304c\u73fe\u5728\/\u4ee5\u524d\u306e\u55ab\u7159\u8005\u306b\u304a\u3051\u308b\u80ba\u6a5f\u80fd\u306e\u6539\u5584\u3068\u5598\u606f\u30ea\u30b9\u30af\u306e\u8efd\u6e1b\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002 <br>\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u304b\u3089\u306e\u9650\u3089\u308c\u305f\u8a3c\u62e0\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u80ba\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u3066\u3001\u73fe\u5728\/\u5143\u55ab\u7159\u8005\u3067\u5598\u606f\u5371\u967a\u3092\u6e1b\u3089\u3059\u3053\u3068\u306b\u3001\u52b9\u679c\u7684\u306a\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002\u6804\u990a\u88dc\u52a9\u98df\u54c1\u3068\u80ba\u304c\u3093\u5371\u967a\u306e\u95a2\u4fc2\u306f\u3001\u5598\u606f\u306b\u304b\u304b\u3063\u305f\u55ab\u7159\u8005\u3068\u975e\u55ab\u7159\u8005\u3067\u3053\u308c\u307e\u3067\u8abf\u3079\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <br>Alsharairi NA. 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Nutrients. 2019;11(4). pii: E725.<\/p>\n\n\n\n<p>C\u00e2mara\u3089\uff082019\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002\u65e5\u5149\u306e\u5c11\u306a\u3044\u56fd\u3005\u3067\u3001\u8180\u80f1\u304c\u3093\u3001\u4e73\u304c\u3093\u3001\u76f4\u8178\u304c\u3093\u3001\u80ba\u304c\u3093\u3001\u98df\u9053\u304c\u3093\u3001\u53e3\u8154\u304c\u3093\u3001\u5375\u5de3\u304c\u3093\u3001\u81b5\u81d3\u304c\u3093\u3001\u76ae\u819a\u304c\u3093\u3001\u80c3\u304c\u3093\u306e\u6b7b\u4ea1\u7387\u304c\u5897\u52a0\u3057\u305f\u3002\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30ea\u30a2\u30ce\u30b8\u30f3\u53d7\u5bb9\u4f53\u3001\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u8907\u5408\u4f53\uff11\u306e\u54fa\u4e73\u52d5\u7269\u6a19\u7684\u3001\u304a\u3088\u3073\u6700\u7d42\u7cd6\u5316\u7523\u7269\u53d7\u5bb9\u4f53\u304c\u764c\u306e\u4e88\u5f8c\u4e0d\u826f\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u3082\u307e\u305f\u89b3\u5bdf\u3055\u308c\u305f\u3002\u30af\u30ed\u30c8\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u306f\u75c5\u6c17\u306e\u4e88\u5f8c\u306e\u6539\u5584\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3002 Nfr2\u306f\u3001\u764c\u306b\u304a\u3051\u308b\u3088\u308a\u60aa\u3044\u4e88\u5f8c\u3068\u3088\u308a\u826f\u3044\u4e88\u5f8c\u306e\u4e21\u65b9\u306b\u95a2\u9023\u3057\u305f\u3002\u6587\u732e\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u304c\u764c\u306e\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002\u5e73\u5747\u65e5\u5149\u304c\u4f4e\u3044\u56fd\u306f\u304c\u3093\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u3068\u7d50\u8ad6\u4ed8\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002 <br>C\u00e2mara AB, et al. The Role of Vitamin D and Sunlight Incidence in Cancer. Anticancer Agents Med Chem. 2019 Mar 12. [Epub ahead of print]<\/p>\n\n\n\n<p>Vojdeman\u3089\uff082019\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002\u30c7\u30f3\u30de\u30fc\u30af\u306e\u9996\u90fd\u570f\u306b\u304a\u3051\u308b217,244\u4eba\u306e\u764c\u306e\u767a\u751f\u7387\u3068\u306e\u95a2\u9023\u6027\u3092\u8abf\u3079\u305f\u300210 nmol \/ L\uff084ng\/ml\uff09\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u5897\u5206\u3068\u3001\u4e73\u304c\u3093\u3001\u7d50\u8178\u76f4\u8178\u304c\u3093\u3001\u5c3f\u8def\u304c\u3093\u3001\u5375\u5de3\u304c\u3093\u3001\u5b50\u5bae\u4f53\u304c\u3093\u306e\u767a\u751f\u7387\u3068\u306e\u9593\u306b\u95a2\u9023\u6027\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u3088\u308a\u9ad8\u3044\u30ec\u30d9\u30eb\u306e\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u524d\u7acb\u817a\u304a\u3088\u3073\u8840\u6db2\u764c\u3068\u540c\u69d8\u306b\u975e\u9ed2\u8272\u816b\u3068\u9ed2\u8272\u816b\u76ae\u819a\u764c\u306e\u3088\u308a\u9ad8\u3044\u767a\u751f\u7387\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u80ba\u764c\u306e\u767a\u751f\u7387\u306f\u4f4e\u304b\u3063\u305f\u3002\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306f\u3044\u304f\u3064\u304b\u306e\u4e3b\u8981\u306a\u764c\u306e\u767a\u751f\u7387\u3068\u306f\u95a2\u9023\u304c\u306a\u3044\u304c\u3001\u3088\u308a\u9ad8\u3044\u6fc3\u5ea6\u306f\u76ae\u819a\u764c\u3001\u524d\u7acb\u817a\u764c\u3001\u8840\u6db2\u764c\u306e\u767a\u751f\u7387\u306e\u4e0a\u6607\u3068\u80ba\u764c\u306e\u767a\u751f\u7387\u306e\u4f4e\u4e0b\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306b\u3088\u308b\u764c\u306b\u5bfe\u3059\u308b\u5168\u4f53\u7684\u306a\u4fdd\u8b77\u52b9\u679c\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002 <br>Vojdeman FJ. et al. Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark. Int J Cancer. 2019 Jul 15;145(2):338-346.<\/p>\n\n\n\n<p>Zhang Y\u3089\uff082019\u5e74\uff09\u306f\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u5927\u4eba\u3067\u4f4e\u3044\u6b7b\u4ea1\u7387\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u8abf\u67fb\u3057\u305f\u3002\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e\u7cfb\u7d71\u7684\u8a55\u4fa1\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08\u591a\u65bd\u8a2d\u7d71\u5408\u5206\u6790\uff09\u3002\u30c7\u30fc\u30bf\u30fb\u30bd\u30fc\u30b9\u306f\u30e1\u30c9\u30e9\u30a4\u30f3\u3001Embase\u30682018\u5e7412\u670826\u65e5\u307e\u3067\u306e\u30b3\u30af\u30e9\u30f3\u672c\u90e8\u767b\u9332\u3002\u7121\u4f5c\u70ba\u8a66\u9a13\u3092\u9078\u3076\u305f\u3081\u306e\u9069\u683c\u57fa\u6e96\u306f\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u507d\u85ac\u307e\u305f\u306f\u7121\u6cbb\u7642\u3068\u6bd4\u8f03\u3057\u3066\u3044\u308b\u7814\u7a76\u3067\u3042\u308b\u3002 <br>\u5408\u8a0852\u7814\u7a76\u306775,454\u4eba\u306e\u53c2\u52a0\u8005\u3067\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u3001\u3059\u3079\u3066\u306e\u539f\u56e0\u6b7b\u4ea1\u7387\uff08\u5371\u967a\u73870.98\u300195%\u306e\u4fe1\u983c\u533a\u95930.95\uff5e1.02\u3001I2=0%\uff09\u3001\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\uff080.98\u30010.88\uff5e1.08\u30010%\uff09\u307e\u305f\u306f\u975e-\u30ac\u30f3\uff08\u975e\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\uff081.05\u30010.93\uff5e1.18\u30010%\uff09\uff09\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u30ac\u30f3\u6b7b\uff080.84\u30010.74\uff5e0.95\u30010%\uff09\u306e\u5371\u967a\u6027\u3092\u7d71\u8a08\u5b66\u7684\u306b\u304b\u306a\u308a\u6e1b\u3089\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D3\u3082\u30d3\u30bf\u30df\u30f3D2\u3082\u3001\u3059\u3079\u3066\u306e\u539f\u56e0\u6b7b\u4ea1\u7387\u306e\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u7e2e\u5c0f\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u3044\u3002 <br>\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3060\u3051\u304c\u3001\u507d\u85ac\u307e\u305f\u306f\u7121\u51e6\u7f6e\u3068\u6bd4\u8f03\u3057\u3066\u5927\u4eba\u3067\u3059\u3079\u3066\u306e\u539f\u56e0\u6b7b\u4ea1\u7387\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u300116%\u30ac\u30f3\u6b7b\u306e\u5371\u967a\u6027\u3092\u6e1b\u3089\u3057\u307e\u3057\u305f\u3002\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u30d3\u30bf\u30df\u30f3D3\u304c\u3059\u3079\u3066\u306e\u539f\u56e0\u6b7b\u4ea1\u7387\u3092\u4e0b\u3052\u308b\u304b\u3069\u3046\u304b\u78ba\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u66f4\u306a\u308b\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\u306f\u5fc5\u8981\u3067\u3059\u3002 <br>Zhang Y, et al. Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ 2019; 366.<\/p>\n\n\n\n<p>Zhang J \u3089\uff082019\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002p62\u306f\u5927\u8178\u764c\u3067\u6709\u610f\u306b\u4e0a\u65b9\u5236\u5fa1\u3055\u308c\u3066\u304a\u308a\u3001\u9ad8p62\u30ec\u30d9\u30eb\u306f\u5927\u8178\u304c\u3093\u60a3\u8005\u306e\u4e88\u5f8c\u4e0d\u826f\u306e\u72ec\u7acb\u3057\u305f\u5371\u967a\u56e0\u5b50\u3067\u3042\u3063\u305f\u3002 P62\u306f\u3001\u8a66\u9a13\u7ba1\u5185\u3067\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5927\u8178\u304c\u3093\u306e\u79fb\u52d5\u304a\u3088\u3073\u6d78\u6f64\u3092\u4fc3\u9032\u3057\u3001\u305d\u3057\u3066p62\u306f\u751f\u4f53\u5185\u3067\u816b\u760d\u306e\u5897\u6b96\u304a\u3088\u3073\u8ee2\u79fb\u3092\u60aa\u5316\u3055\u305b\u305f\u3002 Co-IP\u30a2\u30c3\u30bb\u30a4\u306f\u3001p62\u304c\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001NRF 2 -NQO 1\u8ef8\u3092\u6a19\u7684\u306b\u3057\u5f97\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u7d50\u8ad6\uff1a\u6211\u3005\u306e\u7814\u7a76\u306f\u3001p62\u304c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5927\u8178\u304c\u3093\u306e\u764c\u907a\u4f1d\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002 <br>Zhang J. et al. p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor. Cell Prolif. 2019 May;52(3):e12585.<\/p>\n\n\n\n<p>Zhang X\u3089\uff082018\u5e7410\u6708\u6295\u7a3f\uff09\u306f\u300c\u30d3\u30bf\u30dfD\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308b\u304c\u3093\u306e\u767a\u751f\u3068\u6b7b\u4ea1\u7387\u306b\u95a2\u3059\u308b\u6700\u65b0\u306e\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e\u5206\u6790\u300d\u3092\u767a\u8868\u3057\u305f\u3002 <br><strong>\u76ee\u7684<\/strong>\uff1a\u6211\u3005\u306f\u767a\u8868\u3055\u308c\u305f\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e\u7d50\u679c\u3092\u7dcf\u5408\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u4f4e\u30d3\u30bf\u30df\u30f3D\u304c\u30ac\u30f3\u767a\u751f\u7387\u3068\u6b7b\u4ea1\u7387\u306e\u5897\u52a0\u30ea\u30b9\u30af\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u3088\u3046\u3068\u3057\u305f\u3002\u4e00\u65b9\u3001\u6211\u3005\u306f\u7814\u7a76\u9593\u306e\u6f5c\u5728\u7684\u7570\u8cea\u6027\u3082\u8abf\u67fb\u3057\u305f\u3002 <br><strong>\u65b9\u6cd5<\/strong>\uff1aPubMed\u3068EMBASE\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u3068\u30ac\u30f3\u767a\u751f\u7387\u307e\u305f\u306f\u6b7b\u4ea1\u7387\u306e\u9593\u306e\u95a2\u4fc2\u3092\u8abf\u67fb\u3057\u305f\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u3092\u78ba\u8a8d\u3057\u305f\u3002\u6587\u732e\u691c\u7d22\u3001\u826f\u8cea\u306a\u8a55\u4fa1\u3068\u30c7\u30fc\u30bf\u62bd\u51fa\u306f\u3001\u4e8c\u91cd\u306b\u3001\u305d\u3057\u3066\u72ec\u7acb\u3057\u3066\u5b9f\u884c\u3057\u307e\u3057\u305f\u3002 <br><strong>\u7d50\u679c<\/strong>\uff1a9\u4ef6\u306e\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306f\u300155,491\u4eba\u306e\u8a66\u9a13\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u305d\u308c\u305e\u308c\u3001\u30ac\u30f3\u306e\u767a\u75c7\u7387\u306f\u30d3\u30bf\u30df\u30f3D\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e10.56%\u306810.65%\u3067\u3057\u305f\u3002\u305d\u3057\u3066\u300195%\u306e\u4fe1\u983c\u533a\u9593\uff3bCI\uff3d0.99\uff080.93\uff5e1.05\uff09\uff08P=0.733\uff09\u306e\u6709\u610f\u3067\u306a\u3044\u76f8\u5bfe\u5371\u967a\u5ea6\uff08RR\uff09\u3067\u3057\u305f\u3002\u305d\u308c\u305e\u308c\u3001\u30ac\u30f3\u306e\u6b7b\u4ea1\u7387\u306f\u30d3\u30bf\u30df\u30f3D\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306f2.61%\u30682.92%\u3067\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u5371\u967a\u4e88\u6e2c\u306f\u6709\u610f\u306a\u6e1b\u5c11\u3067\u3057\u305f\uff08RR=0.88\u300195%\u306eCI\uff1a0.80\uff5e0.98\uff08P=0.016\uff09\uff09\u3002\u89b3\u5bdf\u53ef\u80fd\u306a\u7570\u8cea\u6027\u307e\u305f\u306f\u504f\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30ac\u30f3\u306e\u65e2\u5f80\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u4f7f\u7528\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u88dc\u52a9\u5264\u304c\u6f5c\u5728\u7684\u7570\u8cea\u7684\u306a\u3053\u3068\u304c\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5206\u6790\u3067\u5206\u304b\u308a\u307e\u3057\u305f\u3002 <br><strong>\u7d50\u8ad6<\/strong>\uff1a\u6211\u3005\u306e\u8abf\u67fb\u7d50\u679c\u306f\u3001\u7279\u306b\u30ac\u30f3\u306e\u65e2\u5f80\u306e\u306a\u3044\u90e8\u5206\u6bcd\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001\u30d3\u30bf\u30df\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u4f7f\u7528\u307e\u305f\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u88dc\u52a9\u5264\u304c\u3001\u30ac\u30f3\u95a2\u9023\u306e\u6b7b\u4ea1\u7387\u3092\u4e0b\u3052\u308b\u6709\u76ca\u306a\u4f5c\u7528\u3092\u3082\u3064\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3002 <br>Zhang X. et al. An Updated Meta-Analysis of Randomized Controlled Trials on Vitamin D Supplement and Cancer Incidence and Mortality. Lancet Posted: 28 Oct 2018<\/p>\n\n\n\n<p>Scragg\u3089\uff082018\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u6bce\u6708\u53d7\u3051\u305f\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u8abf\u3079\u308b\u3053\u3068\u304c\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306a\u3057\u3067\u3001\u4e00\u822c\u96c6\u56e3\u3067\u30ac\u30f3\u767a\u751f\u7387\u3068\u30ac\u30f3\u6b7b\u4ea1\u7387\u306e\u7e2e\u5c0f\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u304b\u8abf\u67fb\u3057\u305f\u3002 <br>\u30c7\u30b6\u30a4\u30f3\u3001\u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\u3068\u53c2\u52a0\u8005\uff1a\u3053\u308c\u306f\u3001Assessment\uff08ViDA\uff09\u304c\u8abf\u67fb\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u304b\u3089\u306e\u30c7\u30fc\u30bf\u3001\u53c2\u52a0\u8005\u3092\u5bb6\u5ead\u533b\u7642\u3068\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u30fb\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u88dc\u5145\u3057\u305f\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u30012011\u5e744\u67085\u65e5\u304b\u30892012\u5e7411\u67086\u65e5\u307e\u3067\u306e\u30aa\u30fc\u30af\u30e9\u30f3\u30c9\uff08\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\uff09\u306e\u4e8b\u5f8c\u306e\u5206\u6790\u3067\u3042\u308b\u30022015\u5e7412\u670831\u65e5\u306b\u5b8c\u4e86\u3057\u305f\u3002<br>\u53c2\u52a0\u8005\u306f\u300150\uff5e84\u6b73\u306e\u6210\u4eba\u30015,110\u4eba\u306e\u53c2\u52a0\u8005\u306f\u30e9\u30f3\u30c0\u30e0\u5316\u3055\u308c\u30d3\u30bf\u30df\u30f3D3\uff08n = 2,558\uff09\u307e\u305f\u306f\u507d\u85ac\uff08n = 2,552\uff09\u3092\u53d7\u3051\u305f\u3002 <br><strong>\u5e72\u6e09<\/strong>\uff1a \u7d4c\u53e3\u30d3\u30bf\u30df\u30f3D3\u306f\u3001\u6700\u521d\u306e\u5927\u91cf\u77ac\u6642\u6295\u4e0e\u306b\u304a\u3044\u3066200 000 IU\uff085,000\u03bcg\uff09\u306e\u85ac\u3092\u98f2\u3093\u3067\u3001100 000 IU\uff082,500\u03bcg\uff09\u306e\u6bce\u6708\u306e\u670d\u7528\u307e\u305f\u306f\u507d\u85ac\u306b\u3088\u3063\u3066\u30013.3\u5e74\uff08\u7bc4\u56f2\u30012.5-4.2\u5e74\uff09\u306e\u4e2d\u592e\u5024\u307e\u3067\u7d9a\u3051\u305f\u3002 <br>\u4e3b\u8981\u306a\u7d50\u679c\u3068\u51e6\u7f6e\uff1a \u8a66\u9a13\u6295\u85ac\u304c2015\u5e747\u670831\u65e5\u306b\u4e2d\u6b62\u3055\u308c\u308b\u307e\u3067\u3001\u4e8b\u5f8c\u306e\u4e3b\u8981\u306a\u7d50\u679c\u306f\u30e9\u30f3\u30c0\u30e0\u5316\u304b\u3089\u8a3a\u65ad\u3055\u308c\u308b\u3059\u3079\u3066\u306e\u5c40\u6240\u304c\u3093\u304b\u6d78\u6f64\u6027\u60aa\u6027\u65b0\u751f\u7269\uff08\u975e\u9ed2\u8272\u816b\u76ae\u819a\u304c\u3093\u3092\u9664\u5916\u3059\u308b\uff09\u306e\u6570\u3067\u3042\u308b\u3002 <br><strong>\u7d50\u679c<\/strong>\uff1a \u5206\u6790\u306b\u542b\u307e\u308c\u308b5,108\u4eba\u306e\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001\u5e73\u5747\uff08SD\uff09\u306f65.9 (8.3)\u6b73\u3067\u3057\u305f\u300158.1%\u306f\u7537\u6027\u3067\u3057\u305f\u30014,253\u4eba\uff0883.3%\uff09\u306f\u30e8\u30fc\u30ed\u30c3\u30d1\u4eba\u307e\u305f\u306f\u30dd\u30ea\u30cd\u30b7\u30a2\u3067\u3042\u308b\u304b\u3001\u30b5\u30a6\u30b9\u30fb\u30a2\u30b8\u30a2\u4eba\u3067\u3042\u308b\u3002\u5e73\u5747\uff08SD\uff09\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306f\u300126.5 (9.0)ng\/mL\u3067\u3057\u305f\u3002438\u4eba\u306e\u53c2\u52a0\u8005\u306e\u7121\u4f5c\u70ba\u6a19\u672c\u306b\u3001\u5e73\u5747\u7d4c\u904e\u89b3\u5bdf\u306e25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u30d3\u30bf\u30df\u30f3D\u30b0\u30eb\u30fc\u30d7\u3067\u3001\u4e00\u8cab\u3057\u306620ng\/mL\u3092\u8d85\u3048\u308b\u9ad8\u3055\u3067\u3042\u3063\u305f\u3002 <br>\u30ac\u30f3\u306e\u4e3b\u8981\u306a\u7d50\u679c\u306f\u3001259\u306e\u6d78\u6f64\u304c\u3093\u306869\u306e\u5c40\u6240\u60aa\u6027\u65b0\u751f\u7269\u306e328\u4eba\u306e\u75c7\u4f8b\u304b\u3089\u6210\u308a\u3001\u30d3\u30bf\u30df\u30f3D\u30b0\u30eb\u30fc\u30d7\u306e2,558\u4eba\u306e\u53c2\u52a0\u8005\uff086.5%\uff09\u306e\u3046\u3061\u306e165\u4eba\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e2550\uff086.4%\uff09\u306e\u3046\u3061\u306e163\u4eba\u306b\u8d77\u3053\u308a\u307e\u3057\u305f\u3002 <br><strong>\u7d50\u8ad6\u3068\u95a2\u9023<\/strong>\uff1a \u30ab\u30eb\u30b7\u30a6\u30e0\u306a\u3057\u3067\u6bce\u6708\u6700\u9ad84\u5e74\u9593\u306e\u898f\u5b9a\u3055\u308c\u305f\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3001\u30ac\u30f3\u3092\u9632\u6b62\u3057\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3088\u308a\u9577\u3044\u671f\u9593\u306e\u9593\u306e\u6bce\u65e5\u3084\u6bce\u9031\u306e\u6295\u4e0e\u304c\u66f4\u306a\u308b\u7814\u7a76\u3092\u5fc5\u8981\u3068\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3053\u3068\u3092\u3001\u3053\u306e\u7814\u7a76\u306f\u793a\u5506\u3059\u308b\u3002 <br>Scragg R. et al. Monthly High-Dose Vitamin D Supplementation and Cancer Risk: A Post Hoc Analysis of the Vitamin D Assessment Randomized Clinical Trial. JAMA Oncol. 2018 Nov 1;4(11):e182178.<\/p>\n\n\n\n<p>Timerman\u3089\uff082016\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002\u8ee2\u79fb\u6027\u30b9\u30c6\u30fc\u30b8IV\u9ed2\u8272\u816b\u306b\u304a\u3044\u3066\u3088\u308a\u60aa\u3044\u7d50\u679c\u3068\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u6709\u610f\u306a\u95a2\u4fc2\u304c\u793a\u3081\u3057\u305f\u304c\u3001\u975e\u8ee2\u79fb\u6027\u9ed2\u8272\u816b\u60a3\u8005\u3067\u306f\u30ac\u30f3\u306b\u5bfe\u3057\u3066\u30d3\u30bf\u30df\u30f3D\u306e\u6297\u539f\u4f9d\u5b58\u7684\u306a\u514d\u75ab\u5b66\u7684\u5f71\u97ff\u306e\u4eee\u8aac\u3092\u652f\u6301\u3057\u306a\u304b\u3063\u305f\u3002 <br>\u3055\u3089\u306b\u3001\u540c\u3058\u7814\u7a76\u304b\u3089\u3001\u6700\u521d\u306e\u6e2c\u5b9a\u3067\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u3067\u3042\u3063\u305f\u8ee2\u79fb\u6027\u9ed2\u8272\u816b\u60a3\u8005\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306e\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u6709\u610f\u306b\u60aa\u3044\u7d50\u679c\u3067\u3057\u305f\u3002<br>\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5f37\u3044\u6709\u52b9\u6027\u306f\u3001\u6700\u521d\u306b\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3057\u3066\u3044\u3066\uff08\u226420ng\/ml\uff09\u3001\u305d\u3057\u3066\u3001\u4ee5\u964d\u306e25\uff08OH\uff09D\u306e\u4e0d\u5341\u5206\u306a\u5897\u52a0\u307e\u305f\u306f\u6e1b\u5c11\u3067\u3001\u5341\u5206\u306a\u60a3\u8005\u226520 ng\/ml\u3088\u308a\u60aa\u3044\u7d50\u679c\u3067\u3057\u305f<br>\u7d50\u8ad6\u3068\u3057\u3066\u306f\u3001LDH\uff08\u3059\u3067\u306b\u3053\u306e\u75c5\u6c17\u306e\u5f37\u3044\u4e88\u5f8c\u56e0\u5b50\u3068\u3057\u3066\u6709\u540d\uff09\u3088\u308a\u524d\u5146\u306e\u91cd\u8981\u6027\u3067\u3001\u6700\u521d\u306e\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u3068\u4e0d\u5341\u5206\u306a\u5145\u8db3\u306f\u8ee2\u79fb\u6027\u9ed2\u8272\u816b\u60a3\u8005\u3067\u3001\u3088\u308a\u60aa\u3044\u7d50\u679c\u3092\u4e88\u6e2c\u3059\u308b\u3002 <br>Timerman D, et al. Vitamin D deficiency is associated with a worse prognosis in metastatic melanoma. Oncotarget 8(4), 6873-6882 (2016).Google Scholar<\/p>\n\n\n\n<p>Pommergaard\u3089\uff082016\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002<br><strong>\u80cc\u666f\u3068\u72d9\u3044<\/strong>\uff1a\u5316\u5b66\u7684\u4e88\u9632\u6226\u7565\u306f\u3001\u7d50\u8178\u76f4\u8178\u817a\u816b\u306e\u518d\u767a\u3068\u7d50\u8178\u76f4\u8178\u304c\u3093\u306e\u767a\u75c5\u7387\u3092\u6e1b\u3089\u3059\u306e\u306b\u7528\u3044\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002 \u30a2\u30bb\u30c1\u30eb\u30b5\u30eb\u30c1\u30eb\u9178(\u30a2\u30b9\u30d4\u30ea\u30f3)\u3001\u30ab\u30eb\u30b7\u30c8\u30ea\u30aa\u30fc\u30eb\uff08\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D3\u88fd\u5264\uff09\u3068\u70ad\u9178\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u7d44\u5408\u305b\u304c\u7d50\u8178\u76f4\u8178\u817a\u816b\u518d\u767a\u3092\u9632\u6b62\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u6211\u3005\u306f\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3092\u884c\u3063\u305f\u3002 <br><strong>\u65b9\u6cd5<\/strong>\uff1a2004\u5e74\u304b\u30892010\u5e74\u307e\u3067\u3001\u6211\u3005\u306f\u30011,107\u4eba\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u3001\u30ed\u30b7\u30a2\u3001\u30a2\u30e1\u30ea\u30ab\u5408\u8846\u56fd\u306e\u30bb\u30f3\u30bf\u30fc\u3067\u7d50\u8178\u307e\u305f\u306f\u76f4\u8178\u304b\u3089\u53d6\u308a\u9664\u304b\u308c\u308b1\u3064\u4ee5\u4e0a\u306e\u6563\u767a\u7684\u306a\u817a\u816b\u60a3\u8005\u3092\u542b\u3081\u305f\u3002 <br>\u5305\u542b\u57fa\u6e96\u306f\u3001\u76f4\u5f841cm\u3088\u308a\u5927\u304d\u30441\u3064\u306e\u817a\u816b\u3001\u305d\u3057\u3066\u7d50\u8178\u76f4\u8178\u304c\u3093\u3092\u542b\u3080\u3069\u3093\u306a\u30b5\u30a4\u30ba\u306e1\u3064\u4ee5\u4e0a\u306e\u817a\u816b\u30023\u5e74\u9593\u306e\u6bce\u65e5\u30010.5\u03bcg\u30ab\u30eb\u30b7\u30c8\u30ea\u30aa\u30fc\u30eb\u300175mg\u306e\u30a2\u30bb\u30c1\u30eb\u30b5\u30eb\u30c1\u30eb\u9178\u30681,250mg\u306e\u70ad\u9178\u30ab\u30eb\u30b7\u30a6\u30e0(n = 209\u4eba)\u3092\u4e0e\u3048\u3089\u308c\u308b\u30b0\u30eb\u30fc\u30d7\u307e\u305f\u306f\u507d\u85ac(n = 218\u4eba)\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002 \u4e3b\u8981\u306a\u7d50\u679c\u306f\u30013\u5e74\u5f8c\u306b\u7d50\u8178\u93e1\u691c\u67fb\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u308b\u817a\u816b\u518d\u767a\u3060\u3063\u305f\u3002\u7b2c\u4e8c\u306e\u7d50\u679c\u306f\u3001\u9032\u884c\u3057\u305f\u817a\u816b(\u7d50\u8178\u76f4\u8178\u817a\u816b\u306e\u7dcf\u6570)\u3068\u817a\u816b\u30b5\u30a4\u30ba\u3068\u7279\u5fb4\u306e\u4e00\u90e8\u306e\u60a3\u8005\u3060\u3063\u305f\u3002 <br>\u7d50\u679c\u306f\u3001\u7121\u52b9\u306e\u305f\u3081\u30012010\u5e7410\u6708\u306b\u6b62\u3081\u305f\u3002 <br>\u3053\u306e\u5206\u6790\u6cd5\u3067\u306f\u3001\u6211\u3005\u306f\u518d\u767a\u306e\u7387\u3067\u3001\u30b0\u30eb\u30fc\u30d7\u306e\u9055\u3044\u3092\u898b\u3064\u3051\u307e\u305b\u3093\u3067\u3057\u305f(\u30aa\u30c3\u30ba\u6bd4[OR]\u30010.95;95%\u306e\u4fe1\u983c\u533a\u9593[CI]\u30010.61-1.48)\u3002\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5206\u6790\u306f\u3001\u51e6\u7f6e\u304c\u55ab\u7159\u306b\u3088\u3063\u3066\u5f71\u97ff\u3055\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u305f\u3002 <br><strong>\u7d50\u8ad6<\/strong>\uff1a\u524d\u5411\u304d\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30ab\u30eb\u30b7\u30c8\u30ea\u30aa\u30fc\u30eb\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u3068\u70ad\u9178\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u7d44\u5408\u305b\u306f\u30013\u5e74\u306e\u671f\u9593\u306e\u9593\u7d50\u8178\u76f4\u8178\u817a\u816b\u306e\u518d\u767a\u3092\u9632\u6b62\u3057\u306a\u304b\u3063\u305f\u3002\u5426\u5b9a\u7684\u306a\u7d50\u679c\u306f\u3001\u55ab\u7159\u306e\u5f71\u97ff\u307e\u305f\u306f\u30c6\u30b9\u30c8\u3055\u308c\u305f\u85ac\u5264\u306e\u4f4e\u7528\u91cf\u306e\u305f\u3081\u304b\u3082\u3057\u308c\u306a\u3044\u3002 <br>Pommergaard H., et al. Aspirin, Calcitriol, and Calcium Do Not Prevent Adenoma Recurrence in a Randomized Controlled Trial. January 2016Volume 150, Issue1, Pages 114-122.e4<\/p>\n\n\n\n<p>Baron\u3089\uff082015\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002<br><strong>\u80cc\u666f<\/strong>\uff1a\u75ab\u5b66\u7684\u3067\u81e8\u5e8a\u524d\u30c7\u30fc\u30bf\u306f\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u6e05\u30ec\u30d9\u30eb\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u3088\u308a\u9ad8\u3044\u6442\u53d6\u91cf\u306f\u7d50\u8178\u76f4\u8178\u816b\u760d\u5f62\u6210\u306e\u5371\u967a\u6027\u3092\u6e1b\u3089\u3059\u3053\u3068\u3092\u6697\u793a\u3057\u305f\u3002\u3055\u3089\u306b\u3053\u308c\u3089\u306e\u6804\u990a\u5206\u306e\u5316\u5b66\u7684\u4e88\u9632\u53ef\u80fd\u6027\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u3001\u6211\u3005\u306f\u7d50\u8178\u76f4\u8178\u817a\u816b\u306e\u4e88\u9632\u306e\u305f\u3081\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u307e\u305f\u306f\u4e21\u65b9\u3068\u3082\u3067\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002 <br><strong>\u65b9\u6cd5<\/strong>\uff1a \u30e9\u30f3\u30c0\u30e0\u306b\u6bce\u65e5\u306e\u30d3\u30bf\u30df\u30f3D3\uff081,000IU\u300125\u03bcg\uff09\u3092\u53d7\u3051\u308b2,259\u4eba\u306e\u53c2\u52a0\u8005\u3001\u70ad\u9178\u5869\uff081200mg\uff09\u3068\u3057\u3066\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3001\u4e21\u65b9\u3068\u3082\u307e\u305f\u306f\u3069\u3061\u3089\u3082\u5272\u308a\u5f53\u3066\u3089\u308c\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u5973\u6027\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u307e\u305f\u306f\u507d\u85ac\u306b\u7121\u4f5c\u70ba\u5272\u5f53\u3066\u3092\u30d7\u30e9\u30b9\u3057\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u6c7a\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u5185\u8996\u93e1\u691c\u67fb\u5c02\u9580\u533b\u304c\u3001\u57fa\u672c\u7684\u306a\u8a66\u9a13\u306e3\u307e\u305f\u306f5\u5e74\u5f8c\u306b\u7d50\u8178\u93e1\u691c\u67fb\u3092\u884c\u3063\u305f\u3002\u4e3b\u8981\u306a\u76ee\u6a19\u306f\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u304b\u3089\u4e88\u60f3\u3055\u308c\u305f\u7d50\u8178\u93e1\u691c\u67fb\u307e\u3067\u306b\u8a3a\u65ad\u3055\u308c\u308b\u817a\u816b\u3067\u3057\u305f\u3002 <br><strong>\u7d50\u679c<\/strong>\uff1a \u507d\u85ac\u3092\u4e0e\u3048\u3089\u308c\u308b\u53c2\u52a0\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u53d7\u3051\u308b\u3088\u3046\u7121\u4f5c\u70ba\u5272\u4ed8\u3051\u3055\u308c\u305f\u53c2\u52a0\u8005\u306f\u3001\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u304c7.83ng\/ml\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u53c2\u52a0\u8005\u306e43%\u306f\u3001\u4e00\u3064\u4ee5\u4e0a\u306e\u817a\u816b\u3092\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306e\u9593\u3001\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<br>\u518d\u767a\u3059\u308b\u817a\u816b\u306e\u8abf\u7bc0\u3055\u308c\u305f\u30ea\u30b9\u30af\u6bd4\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u5bfe\u30d3\u30bf\u30df\u30f3D\u306a\u30570.99\uff0895%\u306e\u4fe1\u983c\u533a\u9593\uff3bCI\uff3d\uff080.89\uff5e1.09\uff09\uff09\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u5bfe\u30ab\u30eb\u30b7\u30a6\u30e0\u306a\u30570.95\uff0895%\u306eCI\uff080.85\uff5e1.06\uff09\uff09\u3001\u4e21\u65b9\u306e\u30a8\u30fc\u30b8\u30a7\u30f3\u30c8\u5bfe\u3069\u3061\u3089\u306e\u30a8\u30fc\u30b8\u30a7\u30f3\u30c8\u3082\u306a\u30440.93\uff0895%\u306eCI\uff080.80\uff5e1.08\uff09\uff09\u3067\u3057\u305f\u3002\u9032\u884c\u3057\u305f\u817a\u816b\u306e\u305f\u3081\u306e\u8abf\u67fb\u7d50\u679c\u306f\u3001\u985e\u4f3c\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u307b\u3068\u3093\u3069\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u304c\u3042\u308a\u307e\u305b\u3093\u3002 <br><strong>\u7d50\u8ad6<\/strong>\uff1a \u7d50\u8178\u76f4\u8178\u817a\u816b\u306e\u9664\u53bb\u306e\u5f8c\u306e\u30d3\u30bf\u30df\u30f3D3\uff081000IU\uff09\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\uff081200mg\uff09\u307e\u305f\u306f\u4e21\u65b9\u3068\u3082\u306b\u3088\u308b\u6bce\u65e5\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u30013\uff5e5\u5e74\u9593\u306b\u308f\u305f\u3063\u3066\u3001\u518d\u767a\u3059\u308b\u7d50\u8178\u76f4\u8178\u817a\u816b\u306e\u5371\u967a\u6027\u3092\u304b\u306a\u308a\u6e1b\u3089\u3059\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 <br>Baron JA et al. A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas. N Engl J Med. 2015 Oct 15;373(16):1519-30.<\/p>\n\n\n\n<p>Mohr\u3089\uff082015\u5e74\uff09\u306f\u3001\u3088\u308a\u9ad8\u304425\uff08OH\uff09D\u306f\u7d50\u8178\u76f4\u8178\u764c\u60a3\u8005\u306e\u764c\u6b7b\u4ea1\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u60a3\u8005\u3067\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u6b63\u5e38\u30ec\u30d9\u30eb\u306b\u56de\u5fa9\u3059\u308b\u3053\u3068\u306f\u7d50\u8178\u76f4\u8178\u764c\u60a3\u8005\u306e\u3088\u308a\u826f\u3044\u4e88\u5f8c\u306b\u7e4b\u304c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002 <br>Mohr S.B.,et al. Could vitamin D sufficiency improve the survival of colorectal cancer patients? J Steroid Biochem Mol Biol. 2015;148:239-244.<\/p>\n\n\n\n<p>Anic\u3089\uff082014\u5e74\uff09\u306f\u3001\u6241\u5e73\u4e0a\u76ae\u764c\u60a3\u8005\u3067\u306a\u304f\u3001\u9ad825\uff08OH\uff09D\u306e\u80ba\u817a\u764c\u60a3\u8005\u304c\u4f4e25\uff08OH\uff09D\u306b\u3088\u308b\u3088\u308a\u826f\u3044\u751f\u5b58\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f(20)\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u306f\u73fe\u5728\u306e\u7814\u7a76\u306e\u7d50\u679c\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002 <br>Anic GM, Serum vitamin D, vitamin D binding protein, and lung cancer survival. Lung Cancer 2014;86:297-303.<\/p>\n\n\n\n<p class=\"mb40\">Cheng\u3089\uff082013\u5e74\uff09\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u91cf\u6bce\u65e5\uff08\u2265400IU\uff0810\u03bcg\uff09\uff09\u306f\u3001\u7981\u7159\u60a3\u8005\u306e\u9593\u3067\u80ba\u304c\u3093\u306e\u5371\u967a\u6027\u3092\u304b\u306a\u308a\u6e1b\u5c11\u3055\u305b\u305f\u3002 <br>Cheng TY. et al. Vitamin D intake and lung cancer risk in the Women s Health Initiative. Am J Clin Nutr. 2013;98:1002-1011.<\/p>\n\n\n\n<p class=\"anchor\" id=\"vitamin-d-recent-papers\"><\/p>\n\n\n<div class=\"lazyblock-h2-01-Z24pPSJ wp-block-lazyblock-h2-01\"><h2 class=\"h2-01\">\u6700\u8fd1\u306e\u30d3\u30bf\u30df\u30f3D\u8ad6\u6587<\/h2><\/div>\n\n\n<p>\u3053\u3053\u6570\u5e74\u3001\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u3059\u308b\u82f1\u6587\u8ad6\u6587\u306fPubMed\u306b\u3088\u308b\u3068\u6bce\u5e744,000\u672c\u4ee5\u4e0a\u3042\u308b\u3002<\/p>\n\n\n\n<p>Gaksch \u3089\uff082017\u5e74\uff09\u306f\u5831\u544a\u3057\u305f\u3002<br><strong>\u80cc\u666f<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306f\u6b7b\u4ea1\u7387\u306e\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u5834\u5408\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u524d\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D(25[OH]D)\u6fc3\u5ea6\u306e\u691c\u67fb\u65b9\u6cd5\u306e\u6a19\u6e96\u5316\u304c\u306a\u304f\u3001\u500b\u3005\u306e\u53c2\u52a0\u8005\u30c7\u30fc\u30bf(IPD)\u306e\u4ee3\u308f\u308a\u306b\u7dcf\u8a08\u30c7\u30fc\u30bf\u3092\u4f7f\u3063\u305f\u3002\u305d\u3053\u3067\u3001\u6211\u3005\u306f\u6a19\u6e96\u5316\u3055\u308c\u305f\u8840\u6e0525(OH)D\u3068\u6b7b\u4ea1\u7387\u306e\u9593\u306e\u95a2\u4fc2\u3067\u3001IPD\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u884c\u3063\u305f\u3002 <br><strong>\u65b9\u6cd5<\/strong>\uff1a7\u3064\u306e\u4e00\u822c\u7684\u4eba\u53e3\u3092\u542b\u30808\u3064\u306e\u524d\u5411\u304d\u30e8\u30fc\u30ed\u30c3\u30d1\u7814\u7a76\u300225(OH)D\u30c7\u30fc\u30bf\u3092\u6a19\u6e96\u5316\u3059\u308b\u305f\u3081\u306b\u3001 VDSP (\u30d3\u30bf\u30df\u30f3D Standardization Program)\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u4f7f\u3063\u305f\u3002\u4e3b\u8981\u306a\u7d50\u679c\u3068\u3057\u3066\u306e\u5168\u539f\u56e0\u6b7b\u4ea1\u7387\u3001\u305d\u3057\u3066\u3001\u7b2c\u4e8c\u306e\u7d50\u679c\u3068\u3057\u3066\u306e\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u30ac\u30f3\u6b7b\u4ea1\u7387\u306725(OH)D\u3092\u8abf\u67fb\u3057\u305f\u3002 <br><strong>\u8abf\u67fb\u7d50\u679c<\/strong>\uff1a53.8nmol\/L(21.52ng\/ml)\u306e\u4e2d\u592e\u502425(OH)D\u6fc3\u5ea6\u3067\u300126,916\u4eba\u306e\u8a66\u9a13\u53c2\u52a0\u8005(\u5e74\u9f62\u306e\u4e2d\u592e\u502461.6\u5e74\u300158%\u306e\u5973\u6027)\u3092\u5206\u6790\u3057\u305f\u300210.5\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u6642\u9593\u306e\u9593\u30016,802\u4eba\u306e\u4eba\u304c\u4ea1\u304f\u306a\u3063\u305f\u300275~99.99nmol\/L(30-40ng\/ml)\u306e25(OH)D\u6fc3\u5ea6\u3092\u3082\u3064\u53c2\u52a0\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u305d\u308c\u305e\u308c\u300140~49.99\uff0816-20\uff09\u300130~39.99\uff0812-16\uff09\u3001&lt;30nmol\/L\uff0812\uff09\u306e25(OH)D\u30b0\u30eb\u30fc\u30d7\u306e\u6b7b\u4ea1\u7387\u306e\u88dc\u6b63\u30cf\u30b6\u30fc\u30c9\u6bd4(95%\u306e\u4fe1\u983c\u533a\u9593)\u306f\u30011.15(1.00-1.29)\u30011.33(1.16-1.51)\u30681.67(1.44-1.89)\u3060\u3063\u305f\u3002\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u3082\u985e\u4f3c\u306e\u7d50\u679c\u3092\u89b3\u5bdf\u3057\u305f\u3001\u3057\u304b\u3057\u300125(OH)D\u3068\u30ac\u30f3\u6b7b\u4ea1\u7387\u306e\u9593\u306e\u6709\u610f\u306a\u7dda\u5f62\u95a2\u4fc2\u304c\u306a\u304b\u3063\u305f\u3002\u304b\u306a\u308a\u5897\u52a0\u3057\u305f\u6b7b\u4ea1\u7387\u30ea\u30b9\u30af\u304c\u3001125nmol\/L(50ng\/ml)\u307e\u3067\u9ad8\u304425(OH)D\u30ec\u30d9\u30eb\u306b\u3082\u306a\u304b\u3063\u305f\u3002 <br><strong>\u89e3\u91c8<\/strong>\uff1a25(OH)D\u306e\u6a19\u6e96\u5316\u3055\u308c\u305f\u6700\u521d\u306eIPD\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u304a\u3044\u3066\u3001\u4f4e25(OH)D\u306f\u3001\u5168\u539f\u56e0\u6b7b\u4ea1\u7387\u306e\u5371\u967a\u6027\u3092\u5897\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u6cbb\u7642\u304c\u65e9\u6b7b\u306b\u3092\u9632\u6b62\u3059\u308b\u304b\u3069\u3046\u304b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u516c\u8846\u885b\u751f\u3068\u3057\u3066\u91cd\u8981\u3060\u3002 <br>Gaksch et al. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25hydroxyvitamin D in 26916 individuals from a European consortium. PLoS ONE 12(2): e0170791,2017.<\/p>\n\n\n\n<p>Autier\u3089\uff082017\u5e74\uff09\u306f\u3001\u300c\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u975e\u9aa8\u683c\u75be\u60a3\u306b\u5bfe\u3059\u308b\u52b9\u679c\uff1a\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3068\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u306e\u7cfb\u7d71\u7684\u30c1\u30a7\u30c3\u30af\u300d\u5831\u544a\u3057\u305f\u3002 <br>\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u5927\u4eba\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u975e\u9aa8\u683c\u306e\u5065\u5eb7\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u30012012\u5e7412\u670831\u65e5\u307e\u3067\u5831\u544a\u3055\u308c\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u3067\u306f\u78ba\u8a8d\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u305d\u3057\u3066\u3001\u305d\u306e\u3053\u3068\u306f\u89b3\u5bdf\u7814\u7a76\u304b\u3089\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u4e88\u60f3\u3055\u308c\u305f\u3002\u3088\u308a\u6700\u8fd1\u767a\u8868\u3055\u308c\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u7814\u7a76\uff08\u591a\u65bd\u8a2d\u7d71\u5408\u7814\u7a76\uff09\u304c\u904e\u53bb\u306e\u7d50\u8ad6\u3092\u5909\u3048\u308b\u304b\u3069\u3046\u304b\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u6211\u3005\u306f\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u7cfb\u7d71\u7684\u306b\u898b\u76f4\u3057\u305f\u3001\u305d\u3057\u3066\u3001\u975e\u9aa8\u683c\u75be\u60a3\u306f2013\u5e741\u67081\u65e5\u304b\u30892017\u5e745\u670831\u65e5\u306e\u9593\u306b\u3001\u305d\u308c\u306f\u598a\u5a66\u3092\u542b\u3080\u3042\u3089\u3086\u308b\u5e74\u9f62\u306e\u8a66\u9a13\u53c2\u52a0\u8005\u3092\u542b\u3093\u3060\u3002\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u542b\u307e\u308c\u306a\u3044\u30e9\u30f3\u30c0\u30e0\u5316\u3055\u308c\u305f\u7814\u7a76\u3082\u8abf\u3079\u305f\u300287\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08\u6700\u8fd1\u3067\u306a\u3044\u8ad6\u6587\u3092\u542b\u3093\u3060\u304b\u3001\u6700\u9069\u306b\u53ca\u3070\u306a\u3044\u54c1\u8cea\u3060\u3063\u305f\u306e\u3067\u300152\u306f\u9664\u5916\u3057\u305f\uff09\u3092\u7814\u7a76\u3057\u305f\u3002\u6211\u3005\u306f\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u542b\u307e\u308c\u306a\u304b\u3063\u305f\u7814\u7a76\u306b\u95a2\u3059\u308b202\u306e\u8ad6\u6587\u3092\u691c\u7d22\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D1\u65e510-20\u03bcg\u304c\u4e2d\u9ad8\u5e74\u306e\u4eba\u3005\u3067\u5168\u4f53\u539f\u56e0\u6b7b\u4ea1\u7387\u3068\u30ac\u30f3\u6b7b\u4ea1\u7387\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u77e5\u898b\u3092\u3001\u6700\u8fd1\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u652f\u6301\u3059\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u670d\u7528\u304c\u904e\u53bb\u306b\u7814\u7a76\u3055\u308c\u308b\u3088\u308a\u5927\u304d\u304b\u3063\u305f\u304c\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u80a5\u6e80\u75c7\u3001\u7cd6\u4ee3\u8b1d\u3001\u6c17\u5206\u969c\u5bb3\u3001\u7b4b\u8089\u306e\u6a5f\u80fd\u3001\u7d50\u6838\u3068\u7d50\u8178\u76f4\u8178\u817a\u816b\u3001\u6bcd\u3084\u5468\u7523\u671f\u3092\u542b\u3080\u3001\u5927\u90e8\u5206\u306e\u975e\u9aa8\u683c\u75be\u60a3\u306b\u95a2\u3057\u3066\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3044\u3046\u65b0\u3057\u3044\u77e5\u898b\u306f\u306a\u304b\u3063\u305f\u3002\u30ac\u30f3\u7d50\u679c\u306b\u95a2\u3059\u308b\u65b0\u3057\u3044\u30c7\u30fc\u30bf\u306f\u3001\u4e0d\u8db3\u3057\u3066\u3044\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u5168\u8eab\u6027\u708e\u75c7\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u91cd\u8981\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3055\u306a\u3044\u3053\u3068\u3092\u300183\u306e\u7814\u7a76\u304b\u3089\u306e\u7d50\u679c\u306f\u793a\u3057\u305f\u3002\u3053\u306e\u7cfb\u7d71\u7684\u30c1\u30a7\u30c3\u30af\u306b\u3088\u3063\u3066\u6ce8\u76ee\u3055\u308c\u308b\u4e3b\u8981\u306a\u65b0\u3057\u3044\u767a\u898b\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u304c\u666e\u901a\u306e\u4e0a\u6c17\u9053\u611f\u67d3\u75c7\u3068\u5598\u606f\u60aa\u5316\u3092\u9632\u6b62\u3059\u308b\u306e\u3092\u52a9\u3051\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u30d3\u30bf\u30df\u30f3D\u306e\u5897\u52a0\u3057\u305f\u91cf\u306e\u4f7f\u7528\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u5927\u90e8\u5206\u306e\u72b6\u6cc1\uff08\u6162\u6027\u708e\u75c7\u3092\u542b\u3080\uff09\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u307b\u3068\u3093\u3069\u8a3c\u62e0\u306f\u306a\u304b\u3063\u305f\u3002\u305d\u3057\u3066\u3001\u4f4e\u3044\u30d3\u30bf\u30df\u30f3D\u72b6\u6cc1\u304c\u305d\u306e\u539f\u56e0\u3088\u308a\u3082\u3080\u3057\u308d\u4e0d\u5065\u5eb7\u306e\u7d50\u679c\u3067\u3042\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u652f\u6301\u3059\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u6025\u6027\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u62b5\u6297\u3092\u5f37\u5316\u3059\u308b\u514d\u75ab\u8abf\u7bc0\u6027\u52b9\u679c\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3001\u6211\u3005\u306f\u3055\u3089\u306b\u4eee\u5b9a\u3059\u308b\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u306f\u8870\u5f31\u3059\u308b\u500b\u4eba\u3067\u6b7b\u306e\u5371\u967a\u6027\u3092\u6e1b\u3089\u3059\u3002\u6211\u3005\u306f\u6700\u9069\u72b6\u614b\u306b\u53ca\u3070\u306a\u3044\u54c1\u8cea\u306e\u591a\u304f\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u78ba\u8a8d\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3053\u308c\u306f\u91cd\u8981\u3067\u3042\u308b\u3002\u3088\u308a\u5f37\u3044\u8a3c\u62e0\u3092\u751f\u307f\u51fa\u3059\u305f\u3081\u306b\u3001\u540c\u69d8\u306b\u5224\u65ad\u3055\u308c\u308b\u540c\u3058\u7d50\u679c\u3092\u3082\u3064\u53c2\u52a0\u8005\u306e\u305f\u3081\u306e\u30c7\u30fc\u30bf\u304c\u5fc5\u8981\u3067\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5c06\u6765\u306e\u7cfb\u7d71\u7684\u8a55\u4fa1\u306f\u30c7\u30fc\u30bf\u5171\u6709\u306b\u57fa\u3065\u304b\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002 <br>Autier P. et al. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017 Dec;5(12):986-1004.<\/p>\n\n\n\n<p>Theodoratou E.\u3089\uff082014\u5e74\uff09\u306f\u3001\u300c\u30d3\u30bf\u30df\u30f3D\u3068\u8907\u6570\u306e\u5065\u5eb7\u7d50\u679c\uff1a\u7cfb\u7d71\u7684\u8a55\u4fa1\u306e\u30a2\u30f3\u30d6\u30ec\u30e9\u8a55\u4fa1\u3068\u89b3\u5bdf\u7814\u7a76\u3068\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u300d\u3092\u5831\u544a\u3057\u305f\u3002 <br><strong>\u76ee\u7684<\/strong>\uff1a\u591a\u69d8\u306a\u7d50\u679c\u3092\u5143\u306b\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u9023\u3059\u308b\u3001\u504f\u308a\u306e\u5e45\u3001\u6709\u52b9\u6027\u3001\u30d0\u30a4\u30a2\u30b9\u306e\u5b58\u5728\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3002 <br><strong>\u30c7\u30b6\u30a4\u30f3<\/strong>\uff1a\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u307e\u305f\u306f1\u300125-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3001\u305d\u3057\u3066\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e\u89b3\u5bdf\u7814\u7a76\u306e\u3001\u7cfb\u7d71\u7684\u8a55\u4fa1\u3084\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u30a2\u30f3\u30d6\u30ec\u30e9\u8a55\u4fa1\u3002 <br>\u30c7\u30fc\u30bf\u30fb\u30bd\u30fc\u30b9\uff1a\u30e1\u30c9\u30e9\u30a4\u30f3\u3001Embase\u3068\u5f15\u7528\u306e\u62fe\u3044\u4e0a\u3052\u3002 <br><strong>\u9069\u683c\u57fa\u6e96<\/strong>\uff1a3\u7a2e\u985e\u306e\u7814\u7a76\u306f\u3001\u30a2\u30f3\u30d6\u30ec\u30e9\u8a55\u4fa1\u306e\u8cc7\u683c\u304c\u3042\u3063\u305f\uff1a\u5faa\u74b0\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3068\u81e8\u5e8a\u7d50\u679c\u306e\u9593\u306e\u89b3\u5bdf\u95a2\u4fc2\u3092\u8abf\u3079\u305f\u7cfb\u7d71\u7684\u8a55\u4fa1\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff1a\u305d\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u307e\u305f\u306f\u6d3b\u6027\u5316\u5408\u7269(\u30d3\u30bf\u30df\u30f3D\u306e\u3088\u308a\u65b0\u3057\u3044\u5316\u5408\u7269)\u3067\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u8a55\u4fa1\u3057\u3066\u3044\u308b\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002 <br><strong>\u7d50\u679c<\/strong>\uff1a\u8840\u6e05\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306e\u89b3\u5bdf\u7814\u7a76\u3068\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e87\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e107\u306e\u7cfb\u7d71\u7684\u6587\u732e\u30ec\u30d3\u30e5\u30fc\u306874\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u691c\u7d22\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u3068137\u306e\u7d50\u679c\u306e\u95a2\u4fc2\u3092\u8abf\u67fb\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u5e83\u7bc4\u56f2\u306b\u308f\u305f\u308b\u9aa8\u683c\u3001\u60aa\u6027\u3001\u5fc3\u8840\u7ba1\u3001\u81ea\u5df1\u514d\u75ab\u3001\u4f1d\u67d3\u6027\u3001\u4ee3\u8b1d\u6027\u3001\u305d\u306e\u4ed6\u306e\u75c5\u6c17\u3092\u30ab\u30d0\u30fc\u3057\u305f\u300210\u306e\u7d50\u679c\u306f\u89b3\u5bdf\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3068\u7121\u4f5c\u70ba\u5bfe\u7167\u5316\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308a\u8abf\u3079\u305f\u3002\u5229\u7528\u3067\u304d\u308b\u8a3c\u62e0\u306b\u57fa\u3065\u3044\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3068\u51fa\u751f\u4f53\u91cd\u3001\u5b50\u4f9b\u305f\u3061\u306e\u866b\u6b6f\u3001\u6e80\u671f\u306e\u6bcd\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3068\u900f\u6790\u3092\u5fc5\u8981\u3068\u3057\u3066\u3044\u308b\u6162\u6027\u814e\u81d3\u75c5\u60a3\u8005\u306e\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u6fc3\u5ea6\u306e\u9593\u306e\u95a2\u4fc2\u306f\u3042\u308a\u3048\u308b\u3002\u3057\u304b\u3057\u3001\u66f4\u306a\u308b\u7814\u7a76\u3068\u3088\u308a\u4e0a\u624b\u306b\u8a2d\u8a08\u3055\u308c\u305f\u7814\u7a76\u306f\u3088\u308a\u65ad\u56fa\u305f\u308b\u7d50\u8ad6\u3092\u51fa\u3059\u305f\u3081\u306b\u5fc5\u8981\u3060\u3002\u4ee5\u524d\u306e\u30ec\u30dd\u30fc\u30c8\u3068\u5bfe\u7167\u7684\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u307f\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u9aa8\u5869\u5bc6\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u3001\u8001\u4eba\u306e\u9aa8\u6298\u3084\u8ee2\u5012\u306e\u5371\u967a\u6027\u3092\u6e1b\u3089\u3059\u3068\u3044\u3046\u8b70\u8ad6\u3092\u652f\u6301\u3057\u306a\u3044\u3002 <br><strong>\u7d50\u8ad6<\/strong>\uff1a\u6570\u767e\u306e\u7cfb\u7d71\u7684\u8a55\u4fa1\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u306f\u3063\u304d\u308a\u3057\u305f\u5f79\u5272\u306e\u7d0d\u5f97\u306e\u3044\u304f\u8a3c\u62e0\u304c\u5c11\u306a\u304f\u5b58\u5728\u3057\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u7d50\u679c\u306e\u9078\u629e\u3068\u306e\u95a2\u4fc2\u306f\u3042\u308a\u3048\u308b\u3002 <br>Theodoratou E. et al. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014 Apr 1;348:g2035.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d3\u30bf\u30df\u30f3D\u306f\u9aa8\u3092\u4e08\u592b\u306b\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u65e5\u672c\u4eba\u306e8\u5272\u3067\u30d3\u30bf\u30df\u30f3D\u306f\u4e0d\u8db3\u3057\u3066\u304a\u308a\u30014\u5272\u3067\u6b20\u4e4f\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3059\u308b\u3068\u8840\u4e2d\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u304c\u5897\u52a0\u3059\u308b\u3002&hellip; <a class=\"more-link\" href=\"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/department-all\/thoracic-surgery-disease-vitamin-d\/\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u547c\u5438\u5668\u5916\u79d1 \u75be\u60a3\u89e3\u8aac \u30d3\u30bf\u30df\u30f3D\u306e\u57fa\u790e\u77e5\u8b58\uff08\u304c\u3093\u3068\u306e\u95a2\u9023\uff09<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":6375,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5877","page","type-page","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/pages\/5877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/comments?post=5877"}],"version-history":[{"count":62,"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/pages\/5877\/revisions"}],"predecessor-version":[{"id":7187,"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/pages\/5877\/revisions\/7187"}],"up":[{"embeddable":true,"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/pages\/7"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/media\/6375"}],"wp:attachment":[{"href":"https:\/\/www.jikei.ac.jp\/hospital\/kashiwa\/wp-json\/wp\/v2\/media?parent=5877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}