Members
Research Associate : Ayasa TAJIMA
e-mail:a.tajima＠jikei.ac.jp
Career
- 2012
- Graduated
Faculty of Pharmaceutical Sciences (six-year course)
Josai University - 2012-2016
- Graduate Student
Department of Molecular Biology
The Jikei University School of Medicine - 2016
- Ph.D.
Department of Molecular Biology
The Jikei University School of Medicine - 2016-
- present Research Associate
Department of Molecular Biology
The Jikei University School of Medicine - 2019-2020
- Postdoctoral Fellow
Department of Nutritional Sciences
The Pennsylvania State University
Main research subjects
Analysis of interaction between AZ and ATP citrate lyase
Main research contents
We identified ATP citrate lyase (ACLY), a cytosolic enzyme which catalyzes the production of acetyl-CoA that is used for lipid anabolism or acetylation of cellular components by the screening for AZ-binding proteins. I recently reported that AZ1 and AZ2 bind to and activate ACLY in cancer cells. AZ is a negative regulator of cellular polyamines. However, it was unclear what significance of ACLY activity on polyamine metabolism. I am continuing the study for the crosstalk between polyamines metabolism and ACLY through the function of AZ.
バナースペース
Department of Molecular Biology The Jikei University School of Medicine
3-25-8, Nishi-shinbashi
Minato-ku, Tokyo
105-8461, Japan
Phone: +81-3-3433-1111 ext. 2275
Fax: +81-3-3436-3897