1. Research for polyamine regulating protein “Antizyme”(
What is “Antizyme” ?)
(1)Tumor growth and ubiquitin-independent degradation of Myc proteins
mediated by antizyme 2
(2)Identification of antizyme 1- and antizyme 2-interacting proteins and
their function
(3)Regulatory mechanism of ATP-citrate lyase by antizyme
(4)Mechanism of polyamine-induced translational frameshifting of antizyme
mRNA
2. Function and medical application of polyamines
(1)Analyses for physiological functions of polyamines
(2)Analyses of polyamine effects on the translation regulation
(3)Application of polyamines on medical diagnosis
(4)Polyamines and cancer: Urinary diacetylspermine as a tumor marker
(5)Analyses of polyamine effects on RNA structure by using RNA aptamer